1R3J
 
 | | potassium channel KcsA-Fab complex in high concentration of Tl+ | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | Authors: | Zhou, Y, MacKinnon, R. | | Deposit date: | 2003-10-02 | | Release date: | 2003-11-25 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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1R3L
 | | potassium channel KcsA-Fab complex in Cs+ | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CESIUM ION, ... | | Authors: | Zhou, Y, MacKinnon, R. | | Deposit date: | 2003-10-02 | | Release date: | 2003-11-25 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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3QE1
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3QGL
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5VKH
 | | Closed conformation of KcsA Y82A-F103A mutant | | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | | Authors: | Cuello, L.G, Perozo, E, Cortes, D.M. | | Deposit date: | 2017-04-21 | | Release date: | 2017-12-06 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
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1R3K
 | | potassium channel KcsA-Fab complex in low concentration of Tl+ | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | Authors: | Zhou, Y, MacKinnon, R. | | Deposit date: | 2003-10-02 | | Release date: | 2003-11-25 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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3QDO
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1R3I
 | | potassium channel KcsA-Fab complex in Rb+ | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | Authors: | Zhou, Y, MacKinnon, R. | | Deposit date: | 2003-10-02 | | Release date: | 2003-11-25 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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3OUS
 | | MthK channel pore T59A mutant | | Descriptor: | Calcium-gated potassium channel mthK, POTASSIUM ION | | Authors: | Derebe, M.G, Sauer, D.B, Zeng, W, Alam, A, Shi, N, Jiang, Y. | | Deposit date: | 2010-09-15 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites.
Proc.Natl.Acad.Sci.USA, 108, 2011
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5VK6
 | | Open conformation of KcsA non-inactivating E71A mutant | | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | | Authors: | Cuello, L.G, Perozo, E. | | Deposit date: | 2017-04-21 | | Release date: | 2017-12-06 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
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5VKE
 | | Open conformation of KcsA deep-inactivated | | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | | Authors: | Cuello, L.G, Perozo, E, Cortes, D.M. | | Deposit date: | 2017-04-21 | | Release date: | 2017-12-06 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
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3SYO
 | | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium | | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION | | Authors: | Whorton, M.R, MacKinnon, R. | | Deposit date: | 2011-07-18 | | Release date: | 2011-10-12 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.54 Å) | | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
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3SYP
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3SYC
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3SYQ
 | | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant in complex with PIP2 | | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Whorton, M.R, MacKinnon, R. | | Deposit date: | 2011-07-18 | | Release date: | 2011-10-12 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.44 Å) | | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
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3SYA
 | | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium and PIP2 | | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ... | | Authors: | Whorton, M.R, MacKinnon, R. | | Deposit date: | 2011-07-16 | | Release date: | 2011-10-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
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1PNH
 | | SOLUTION STRUCTURE OF PO5-NH2, A SCORPION TOXIN ANALOG WITH HIGH AFFINITY FOR THE APAMIN-SENSITIVE POTASSIUM CHANNEL | | Descriptor: | SCORPION TOXIN | | Authors: | Meunier, S, Bernassau, J.-M, Sabatier, J.-M, Martin-Eauclaire, M.-F, Van Rietschoten, J, Cambillau, C, Darbon, H. | | Deposit date: | 1993-08-25 | | Release date: | 1994-01-31 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of P05-NH2, a scorpion toxin analog with high affinity for the apamin-sensitive potassium channel.
Biochemistry, 32, 1993
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1ORS
 | | X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab | | Descriptor: | 33H1 Fab heavy chain, 33H1 Fab light chain, potassium channel | | Authors: | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | | Deposit date: | 2003-03-14 | | Release date: | 2003-05-06 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
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6CNN
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6CNM
 | | Cryo-EM structure of the human SK4/calmodulin channel complex | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ... | | Authors: | Lee, C.H, MacKinnon, R. | | Deposit date: | 2018-03-08 | | Release date: | 2018-05-02 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
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6V8Y
 | | Structure of a Sodium Potassium ion Channel | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein, ... | | Authors: | Roy, R, Weiss, K.L, Coates, L. | | Deposit date: | 2019-12-12 | | Release date: | 2021-04-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Structural plasticity of the selectivity filter in a nonselective ion channel.
Iucrj, 8, 2021
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6XEV
 | | CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2 | | Descriptor: | CHOLESTEROL HEMISUCCINATE, G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, ... | | Authors: | Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A. | | Deposit date: | 2020-06-14 | | Release date: | 2021-09-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Rep, 36, 2021
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6XEU
 | | CryoEM structure of GIRK2PIP2* - G protein-gated inwardly rectifying potassium channel GIRK2 with PIP2 | | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ... | | Authors: | Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A. | | Deposit date: | 2020-06-13 | | Release date: | 2021-09-01 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Rep, 36, 2021
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7LJ5
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7LJB
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