PDB: 5434 resultsInfo pagesStatus searchChemie searchBIRD

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2IG0	Structure of 53BP1/methylated histone peptide complex Descriptor: Dimethylated Histone H4-K20 peptide, SULFATE ION, Tumor suppressor p53-binding protein 1 Authors: Mer, G. Deposit date: 2006-09-22 Release date: 2007-01-02 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair. Cell(Cambridge,Mass.), 127, 2006
7QDL	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 with I-BET567 Descriptor: (2S,4R)-1-acetyl-4-((5-chloropyrimidin-2-yl)amino)-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Chung, C. Deposit date: 2021-11-27 Release date: 2022-12-14 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. J.Med.Chem., 65, 2022
8K4L	Crystal structure of NRF1 homodimer in complex with DNA Descriptor: DNA (14-MER), GLYCEROL, Nuclear respiratory factor 1 Authors: Liu, K, Li, W.F, Min, J.R. Deposit date: 2023-07-19 Release date: 2023-12-06 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular mechanism of specific DNA sequence recognition by NRF1. Nucleic Acids Res., 52, 2024
2JVN	Domain C of human PARP-1 Descriptor: Poly [ADP-ribose] polymerase 1, ZINC ION Authors: Hoffman, D, Tao, Z, Liu, H. Deposit date: 2007-09-24 Release date: 2008-05-13 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. Biochemistry, 47, 2008
7QNZ	human Lig1-DNA-PCNA complex reconstituted in absence of ATP Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ... Authors: Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. Deposit date: 2021-12-23 Release date: 2023-01-11 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.58 Å) Cite: Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
2JHW	CRYSTAL STRUCTURE OF RHOGDI E155A, E157A MUTANT Descriptor: RHO GDP-DISSOCIATION INHIBITOR 1, SULFATE ION Authors: Cooper, D.R, Grelewska, K, Derewenda, Z.S. Deposit date: 2007-02-23 Release date: 2007-05-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Protein Crystallization by Surface Entropy Reduction: Optimization of the Ser Strategy Acta Crystallogr.,Sect.D, 63, 2007
8OOI	Full composite cryo-EM map of p97/VCP in ADP.Pi state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Cheng, T.C, Sakata, E, Schuetz, A.K. Deposit date: 2023-04-05 Release date: 2024-01-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: Characterizing ATP processing by the AAA+ protein p97 at the atomic level. Nat.Chem., 16, 2024
7AUC	Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Chen, X, Oliver, A.W. Deposit date: 2020-11-02 Release date: 2020-12-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, 10, 2021
2JHU	CRYSTAL STRUCTURE OF RHOGDI E154A,E155A MUTANT Descriptor: RHO GDP-DISSOCIATION INHIBITOR 1, SULFATE ION Authors: Cooper, D.R, Pinkowska, M, Derewenda, Z.S. Deposit date: 2007-02-23 Release date: 2007-05-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Protein Crystallization by Surface Entropy Reduction: Optimization of the Ser Strategy Acta Crystallogr.,Sect.D, 63, 2007
7QXX	Proteasome-ZFAND5 Complex Z+E state Descriptor: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... Authors: Zhu, Y, Lu, Y. Deposit date: 2022-01-27 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXN	Proteasome-ZFAND5 Complex Z+A state Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... Authors: Zhu, Y, Lu, Y. Deposit date: 2022-01-26 Release date: 2023-02-08 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXP	Proteasome-ZFAND5 Complex Z+B state Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... Authors: Zhu, Y, Lu, Y. Deposit date: 2022-01-26 Release date: 2023-02-08 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QYB	Proteasome-ZFAND5 Complex Z-C state Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... Authors: Zhu, Y, Lu, Y. Deposit date: 2022-01-27 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXU	Proteasome-ZFAND5 Complex Z+C state Descriptor: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... Authors: Zhu, Y, Lu, Y. Deposit date: 2022-01-27 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXW	Proteasome-ZFAND5 Complex Z+D state Descriptor: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... Authors: Zhu, Y, Lu, Y. Deposit date: 2022-01-27 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7AYH	Crystal structure of Aurora A in complex with 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-one derivative (compound 2c) Descriptor: 7-[2-[(4-methoxyphenyl)amino]pyrimidin-4-yl]-1,3,4,5-tetrahydro-1-benzazepin-2-one, Aurora kinase A Authors: Chaikuad, A, Karatas, M, Kunick, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2020-11-12 Release date: 2021-01-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors. Molecules, 26, 2021
8OK2	Bipartite interaction of TOPBP1 with the GINS complex Descriptor: DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ... Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2023-03-26 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nat Commun, 15, 2024
7AXS	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 1 Descriptor: CS-VIP8, (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-12-15 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7QTT	Structural organization of a late activated human spliceosome (Baqr, core region) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... Authors: Cretu, C, Pena, V. Deposit date: 2022-01-15 Release date: 2023-05-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of catalytic activation in human splicing. Nature, 617, 2023
8ODP	Structure of human RTCB with GMPCPP in complex with Archease Descriptor: MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Protein archease, ... Authors: Kopp, J, Gerber, J.L, Peschek, J. Deposit date: 2023-03-09 Release date: 2024-03-27 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. Nat Commun, 15, 2024
7REL	Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-060 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[2-chloro-5-({2-[3-fluoro-4-(1-methylpiperidin-4-yl)anilino]-5-methylpyrimidin-4-yl}amino)phenyl]-2-methylpropane-2-sulfonamide Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2021-07-13 Release date: 2021-07-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-060 To Be Published
7REM	Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050 Descriptor: Bromodomain-containing protein 4, N-[2-chloro-5-({2-[3-fluoro-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)phenyl]-2-methylpropane-2-sulfonamide Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2021-07-13 Release date: 2021-07-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050 To Be Published
8OF5	Crystal structure of Aurora A 122-403 C290A, N332A, Q335A, C393A bound to ADP Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Miles, J.A, Hammond, K.L.R, Bayliss, R. Deposit date: 2023-03-14 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Crystal structure of Aurora A 122-403 C290A, N332A, Q335A, C393A bound to ADP To Be Published
7REK	Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2021-07-13 Release date: 2021-07-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086 To Be Published
8K14	X-ray crystal structure of 18a in BRD4(1) Descriptor: 4-[8-methoxy-2-methyl-1-(1-phenylethyl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole, Bromodomain-containing protein 4 Authors: Xu, H, Shen, H, Zhang, Y, Xu, Y, Li, R. Deposit date: 2023-07-10 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation. Eur.J.Med.Chem., 263, 2024

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