7REK

Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086

Summary for 7REK

• Entry DOI: 10.2210/pdb7rek/pdb
• Descriptor: Bromodomain-containing protein 4, N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bet, jak2, dual brd-kinase inhibitor, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 31502.42

Authors

Karim, M.R.,Schonbrunn, E. (deposition date: 2021-07-13, release date: 2021-07-21, Last modification date: 2023-10-18)

• Primary citation: Karim, M.R.,Schonbrunn, E.; Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.2 Å)