7REK
Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086
Summary for 7REK
Entry DOI | 10.2210/pdb7rek/pdb |
Descriptor | Bromodomain-containing protein 4, N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bet, jak2, dual brd-kinase inhibitor, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31502.42 |
Authors | Karim, M.R.,Schonbrunn, E. (deposition date: 2021-07-13, release date: 2021-07-21, Last modification date: 2023-10-18) |
Primary citation | Karim, M.R.,Schonbrunn, E. Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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