7REM

Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050

Summary for 7REM

• Entry DOI: 10.2210/pdb7rem/pdb
• Descriptor: Bromodomain-containing protein 4, N-[2-chloro-5-({2-[3-fluoro-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)phenyl]-2-methylpropane-2-sulfonamide (3 entities in total)
• Functional Keywords: bet, jak2, dual brd-kinase inhibitor, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15714.47

Authors

Karim, M.R.,Schonbrunn, E. (deposition date: 2021-07-13, release date: 2021-07-21, Last modification date: 2023-10-18)

• Primary citation: Karim, M.R.,Schonbrunn, E.; Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)