7QQL
 
 | | The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 | | Descriptor: | CALCIUM ION, GLYCEROL, Gamma-2-syntrophin,Annexin A2, ... | | Authors: | Cousido-Siah, A, Trave, G, Gogl, G. | | Deposit date: | 2022-01-10 | | Release date: | 2022-04-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | A scalable strategy to solve structures of PDZ domains and their complexes.
Acta Crystallogr D Struct Biol, 78, 2022
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7QQN
 | | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 | | Descriptor: | CALCIUM ION, GLYCEROL, Gamma-1-syntrophin,Annexin A2, ... | | Authors: | Cousido-Siah, A, Trave, G, Gogl, G. | | Deposit date: | 2022-01-10 | | Release date: | 2022-04-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | A scalable strategy to solve structures of PDZ domains and their complexes.
Acta Crystallogr D Struct Biol, 78, 2022
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7QQM
 | | The PDZ domain of LRRC7 fused with ANXA2 | | Descriptor: | CALCIUM ION, GLYCEROL, Leucine-rich repeat-containing protein 7,Annexin A2 | | Authors: | Cousido-Siah, A, Trave, G, Gogl, G. | | Deposit date: | 2022-01-10 | | Release date: | 2022-04-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A scalable strategy to solve structures of PDZ domains and their complexes.
Acta Crystallogr D Struct Biol, 78, 2022
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7BGF
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7QP6
 | | Structure of the human 48S initiation complex in open state (h48S AUG open) | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | | Deposit date: | 2022-01-03 | | Release date: | 2022-05-11 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.
Nucleic Acids Res., 50, 2022
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2IPX
 | | Human Fibrillarin | | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, CALCIUM ION, rRNA 2'-O-methyltransferase fibrillarin | | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-10-12 | | Release date: | 2006-10-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | The Crystal Structure of Human Fibrillarin in complex with SAH
To be Published
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7QI1
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2IU1
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8JF5
 | | Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440 | | Descriptor: | 4-[5-[(3~{R})-3-azanylpyrrolidin-1-yl]carbonyl-2-[2-fluoranyl-4-(2-methyl-2-oxidanyl-propyl)phenyl]phenyl]-2-fluoranyl-benzenecarbonitrile, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | Authors: | Fukushima, H, Machida, T, Yamashita, S, Suzuki, T. | | Deposit date: | 2023-05-17 | | Release date: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | TAS1440, a histone H3 competitive LSD1 inhibitor, activates both TGF-beta and notch signaling pathways via INSM1 dissociation in neuroendocrine small cell lung cancer
To Be Published
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7BK4
 | | Crystal structure of RXRalpha ligand binding domain in complex with a fragment of the TIF2 coactivator | | Descriptor: | 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | | Authors: | le Maire, A, Bourguet, W. | | Deposit date: | 2021-01-15 | | Release date: | 2021-08-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).
J.Mol.Biol., 433, 2021
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2J4Z
 | | Structure of Aurora-2 in complex with PHA-680626 | | Descriptor: | 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ARSENIC, SERINE THREONINE-PROTEIN KINASE 6 | | Authors: | Cameron, A.D, Izzo, G, Storici, P, Rusconi, L, Fancelli, D, Varasi, M, Berta, D, Bindi, S, Forte, B, Severino, D, Tonani, R, Vianello, P. | | Deposit date: | 2006-09-08 | | Release date: | 2006-11-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
J. Med. Chem., 49, 2006
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8JNZ
 | | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor | | Descriptor: | 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | | Authors: | Wang, X.Y, Wang, C.Y, Zhou, J, Xu, B.L. | | Deposit date: | 2023-06-06 | | Release date: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor
To Be Published
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7BED
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7BCY
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8J8M
 | | Overall structure of the LAT1-4F2hc bound with tryptophan | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Large neutral amino acids transporter small subunit 1, ... | | Authors: | Yan, R.H, Li, Y.N, Shi, T.H. | | Deposit date: | 2023-05-02 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Overall structure of the LAT1-4F2hc bound with tryptophan
To Be Published
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8OJ8
 | | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | | Deposit date: | 2023-03-24 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
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6ZVH
 | | EDF1-ribosome complex | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R. | | Deposit date: | 2020-07-24 | | Release date: | 2020-08-19 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | EDF1 coordinates cellular responses to ribosome collisions.
Elife, 9, 2020
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8JUW
 | | Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | | Authors: | Cho, C, Song, J. | | Deposit date: | 2023-06-27 | | Release date: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
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8JUZ
 | | Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class III) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | | Authors: | Cho, C, Song, J. | | Deposit date: | 2023-06-27 | | Release date: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (4.29 Å) | | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
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8JUY
 | | Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class II) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | | Authors: | Cho, C, Song, J. | | Deposit date: | 2023-06-27 | | Release date: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (4.34 Å) | | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
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7A4U
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8OK0
 | | Crystal structure of human NQO1 in complex with the inhibitor PMSF | | Descriptor: | ACETYL GROUP, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | Authors: | Martin-Garcia, J.M, Grieco, A, Ruiz-Fresneda, M.A. | | Deposit date: | 2023-03-26 | | Release date: | 2023-11-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural dynamics at the active site of the cancer-associated flavoenzyme NQO1 probed by chemical modification with PMSF.
Febs Lett., 597, 2023
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6ZP4
 | | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2020-07-08 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
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7QBW
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2IE7
 | | Annexin V under 2.0 MPa pressure of nitrous oxide | | Descriptor: | Annexin A5, CALCIUM ION, NITROUS OXIDE, ... | | Authors: | Colloc'h, N, Sopkova-de Oliveira Santos, J, Prange, T, Brisson, A, Langlois d'Estainto, B, Gallois, B. | | Deposit date: | 2006-09-18 | | Release date: | 2007-02-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action
Biophys.J., 92, 2007
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