4O7Q
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6GLU
| Crystal structure of hMTH1 D120N in complex with LW14 in the presence of acetate | Descriptor: | 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase | Authors: | Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A. | Deposit date: | 2018-05-23 | Release date: | 2019-02-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | hMTH1 D120N in complex with LW14 To Be Published
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6GJO
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6GLF
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6GLL
| Crystal structure of hMTH1 N33A in complex with LW14 in the presence of acetate | Descriptor: | 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... | Authors: | Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A. | Deposit date: | 2018-05-23 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.395 Å) | Cite: | hMTH1 N33A in complex with LW14 To Be Published
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4OR0
| Crystal Structure of Bovine Serum Albumin in complex with naproxen | Descriptor: | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, DI(HYDROXYETHYL)ETHER, Serum albumin, ... | Authors: | Zielinski, K, Bujacz, A, Sekula, B, Bujacz, G. | Deposit date: | 2014-02-10 | Release date: | 2014-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structural studies of bovine, equine, and leporine serum albumin complexes with naproxen. Proteins, 82, 2014
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5DQ6
| Mus musculus A20 OTU domain | Descriptor: | Tumor necrosis factor alpha-induced protein 3 | Authors: | Mabbitt, P.D, Jackson, C.J. | Deposit date: | 2015-09-14 | Release date: | 2015-12-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mus musculus A20 OTU domain To Be Published
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4QHO
| Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with CCO10 | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase FTO, N-{[3-hydroxy-6-(naphthalen-1-yl)pyridin-2-yl]carbonyl}glycine, ZINC ION | Authors: | Aik, W.S, Clunie-O'Connor, C, McDonough, M.A, Schofield, C.J. | Deposit date: | 2014-05-28 | Release date: | 2015-06-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J.Med.Chem., 64, 2021
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4N9F
| Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex | Descriptor: | Core-binding factor subunit beta, Cullin-5, Transcription elongation factor B polypeptide 1, ... | Authors: | Guo, Y.Y, Dong, L.Y, Huang, Z.W. | Deposit date: | 2013-10-21 | Release date: | 2014-01-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif Nature, 505, 2014
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4QNQ
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1XLS
| Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs | Descriptor: | (9cis)-retinoic acid, 3,5-DICHLORO-2-{4-[(3,5-DICHLOROPYRIDIN-2-YL)OXY]PHENOXY}PYRIDINE, Nuclear receptor coactivator 2, ... | Authors: | Suino, K, peng, L, Reynolds, R, Li, Y, Cha, J.-Y, Repa, J.J, Kliewer, S.A, Xu, H.E. | Deposit date: | 2004-09-30 | Release date: | 2004-12-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol.Cell, 16, 2004
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7E4A
| Crystal structure of MIF bound to compound 13 | Descriptor: | CHLORIDE ION, Flavoxate, Macrophage migration inhibitory factor, ... | Authors: | Fa, C.P, Guo, D.Y, Yang, L. | Deposit date: | 2021-02-11 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.475 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E49
| Crystal structure of MIF bound to compound10 | Descriptor: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C.P, Guo, D.Y, Yang, L. | Deposit date: | 2021-02-11 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.574 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E47
| Crystal structure of compound 6 bound to MIF | Descriptor: | (2S,3R,4R,5R,6R)-2-[(2S,3R,4S,5R,6S)-6-(hydroxymethyl)-2-[[(2R,4R)-2-(4-hydroxyphenyl)-4,5-bis(oxidanyl)-3,4-dihydro-2H-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-6-methyl-oxane-3,4,5-triol, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C.P, Yang, L, Guo, D.Y. | Deposit date: | 2021-02-10 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E4B
| Crystal structure of MIF bound to compound 5 | Descriptor: | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C.P, Guo, D.Y, Yang, L. | Deposit date: | 2021-02-11 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.772 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E4C
| Crystal structure of MIF bound to compound11 | Descriptor: | 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, CHLORIDE ION, Macrophage migration inhibitory factor, ... | Authors: | Fan, C.P, Guo, D.Y, Yang, L. | Deposit date: | 2021-02-11 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.644 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E45
| Crystal structure of compound 7 bound to MIF | Descriptor: | (2R)-7-[(2R,3R,4R,5S,6S)-6-(hydroxymethyl)-3-[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,5-bis(oxidanyl)oxan-2-yl]oxy-2-(4-methoxy-3-oxidanyl-phenyl)-5-oxidanyl-2,3-dihydrochromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C.P, Yang, L. | Deposit date: | 2021-02-10 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.433 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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4NG2
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4R9J
| L-ficolin complexed to glucosamine-6-sulfate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-6-O-sulfo-alpha-D-glucopyranose, ACETATE ION, ... | Authors: | Laffly, E, Lacroix, M, Martin, L, Vassal-Stermann, E, Thielens, N, Gaboriaud, C. | Deposit date: | 2014-09-05 | Release date: | 2014-11-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human ficolin-2 recognition versatility extended: An update on the binding of ficolin-2 to sulfated/phosphated carbohydrates. Febs Lett., 588, 2014
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2B50
| Human Nuclear Receptor-Ligand Complex 2 | Descriptor: | CALCIUM ION, Peroxisome proliferator activated receptor delta, VACCENIC ACID, ... | Authors: | Fyffe, S.A, Alphey, M.S, Buetow, L, Smith, T.K, Ferguson, M.A.J, Sorensen, M.D, Bjorkling, F, Hunter, W.N. | Deposit date: | 2005-09-27 | Release date: | 2006-02-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids J.Mol.Biol., 356, 2006
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4RGL
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4RQE
| human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ... | Authors: | Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q. | Deposit date: | 2014-11-03 | Release date: | 2015-11-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res., 43, 2015
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2BAW
| Human Nuclear Receptor-Ligand Complex 1 | Descriptor: | Peroxisome proliferator activated receptor delta, VACCENIC ACID, heptyl beta-D-glucopyranoside | Authors: | Fyffe, S.A, Alphey, M.S, Buetow, L, Smith, T.K, Ferguson, M.A.J, Sorensen, M.D, Bjorkling, F, Hunter, W.N. | Deposit date: | 2005-10-15 | Release date: | 2006-01-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Reevaluation of the PPAR-beta/delta Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form Mol.Cell, 21, 2006
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4OLT
| Chitosanase complex structure | Descriptor: | 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, Chitosanase, GLYCEROL | Authors: | Liu, W.Z, Lyu, Q.Q, Han, B.Q. | Deposit date: | 2014-01-25 | Release date: | 2014-04-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural insights into the substrate-binding mechanism for a novel chitosanase. Biochem.J., 461, 2014
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1ZEO
| Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist | Descriptor: | (2S)-(4-ISOPROPYLPHENYL)[(2-METHYL-3-OXO-5,7-DIPROPYL-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)OXY]ACETATE, Peroxisome proliferator activated receptor gamma | Authors: | Shi, G.Q, Dropinski, J.F, McKeever, B.M, Adams, A.D, MacNaul, K.L, Elbrecht, A, Berger, J.P, Zhou, G, Doebber, T.W. | Deposit date: | 2005-04-19 | Release date: | 2006-04-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity J.Med.Chem., 48, 2005
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