1XLS

Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs

Summary for 1XLS

• Entry DOI: 10.2210/pdb1xls/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, Nuclear receptor coactivator 2, ... (6 entities in total)
• Functional Keywords: lbd, nuclear receptor, car, xenobiotic, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 O35627 Q9WUI9
• Total number of polymer chains: 16
• Total formula weight: 235875.12

Authors

Suino, K.,peng, L.,Reynolds, R.,Li, Y.,Cha, J.-Y.,Repa, J.J.,Kliewer, S.A.,Xu, H.E. (deposition date: 2004-09-30, release date: 2004-12-28, Last modification date: 2024-02-14)

• Primary citation: Suino, K.,Peng, L.,Reynolds, R.,Li, Y.,Cha, J.Y.,Repa, J.J.,Kliewer, S.A.,Xu, H.E.; The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.; Mol.Cell, 16:893-905, 2004; PubMed: 15610733; DOI: 10.1016/j.molcel.2004.11.036

Experimental method

X-RAY DIFFRACTION (2.96 Å)