1XLS
Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Retinoic acid receptor RXR-alpha | polymer | 232 | 26011.1 | 4 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (human) | |
| 2 | E, F, G, H (E, F, G, H) | Orphan nuclear receptor NR1I3 | polymer | 242 | 28004.4 | 4 | UniProt (O35627) Pfam (PF00104) | Mus musculus (house mouse) | Constitutive androstane receptor, CAR |
| 3 | I, J, K, L, M... (I, J, K, L, M...) | Nuclear receptor coactivator 2 | polymer | 18 | 2125.4 | 8 | UniProt (Q9WUI9) | Rattus norvegicus | NCoA-2, Transcriptional intermediary factor 2 |
| 4 | Q, R, S, T (A, B, C, D) | (9cis)-retinoic acid | non-polymer | 300.4 | 4 | Chemie (9CR) | |||
| 5 | U, V, W, X (E, F, G, H) | 3,5-DICHLORO-2-{4-[(3,5-DICHLOROPYRIDIN-2-YL)OXY]PHENOXY}PYRIDINE | non-polymer | 402.1 | 4 | Chemie (TCD) | |||
| 6 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
E, F, G, H: 117 - 358 (UniProt: O35627)
I, J, K, L, M, N, O, P: 739 - 756 (UniProt: Q9WUI9)
| PDB | External Database | Details |
|---|---|---|
| Arg 146 | Lys 146 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 739 | Lys 740 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 233065.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2810.0 | |
| All* | Total formula weight | 235875.1 |
