1XLS
Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003707 | molecular_function | nuclear steroid receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0004879 | molecular_function | nuclear receptor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0003677 | molecular_function | DNA binding |
| F | 0004879 | molecular_function | nuclear receptor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0003677 | molecular_function | DNA binding |
| G | 0004879 | molecular_function | nuclear receptor activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0003677 | molecular_function | DNA binding |
| H | 0004879 | molecular_function | nuclear receptor activity |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 9CR A 801 |
| Chain | Residue |
| A | ILE268 |
| A | ALA327 |
| A | HIS435 |
| A | LEU436 |
| A | ALA271 |
| A | ALA272 |
| A | GLN275 |
| A | TRP305 |
| A | LEU309 |
| A | PHE313 |
| A | ARG316 |
| A | LEU326 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 9CR B 802 |
| Chain | Residue |
| B | ILE268 |
| B | ALA271 |
| B | ALA272 |
| B | GLN275 |
| B | TRP305 |
| B | LEU309 |
| B | PHE313 |
| B | ARG316 |
| B | LEU326 |
| B | ALA327 |
| B | HIS435 |
| B | LEU436 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 9CR C 803 |
| Chain | Residue |
| C | ILE268 |
| C | ALA271 |
| C | ALA272 |
| C | GLN275 |
| C | TRP305 |
| C | LEU309 |
| C | PHE313 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | HIS435 |
| C | LEU436 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 9CR D 804 |
| Chain | Residue |
| D | ILE268 |
| D | ALA271 |
| D | ALA272 |
| D | GLN275 |
| D | LEU309 |
| D | PHE313 |
| D | ARG316 |
| D | LEU326 |
| D | ALA327 |
| D | HIS435 |
| D | LEU436 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TCD E 805 |
| Chain | Residue |
| E | PHE142 |
| E | ASN175 |
| E | LEU216 |
| E | PHE227 |
| E | CYS229 |
| E | TYR234 |
| E | PHE244 |
| E | PHE248 |
| E | ILE252 |
| E | TYR336 |
| E | GLU339 |
| E | LEU340 |
| E | LEU346 |
| E | THR350 |
| E | LEU353 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TCD F 806 |
| Chain | Residue |
| F | HOH88 |
| F | PHE142 |
| F | ASN175 |
| F | LEU216 |
| F | PHE227 |
| F | CYS229 |
| F | TYR234 |
| F | PHE244 |
| F | PHE248 |
| F | ILE252 |
| F | TYR336 |
| F | GLU339 |
| F | LEU340 |
| F | LEU346 |
| F | THR350 |
| F | LEU353 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TCD G 807 |
| Chain | Residue |
| G | PHE142 |
| G | ASN175 |
| G | LEU216 |
| G | PHE227 |
| G | CYS229 |
| G | TYR234 |
| G | PHE244 |
| G | PHE248 |
| G | ILE252 |
| G | TYR336 |
| G | GLU339 |
| G | LEU340 |
| G | LEU346 |
| G | THR350 |
| G | LEU353 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TCD H 808 |
| Chain | Residue |
| H | PHE244 |
| H | PHE248 |
| H | ILE252 |
| H | TYR336 |
| H | GLU339 |
| H | LEU340 |
| H | LEU346 |
| H | THR350 |
| H | LEU353 |
| H | PHE142 |
| H | ASN175 |
| H | LEU216 |
| H | PHE227 |
| H | CYS229 |
| H | TYR234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | SITE: Important for TCPOBOP recognition |
| Chain | Residue | Details |
| E | PHE171 | |
| F | PHE227 | |
| F | PHE244 | |
| F | TYR336 | |
| G | PHE171 | |
| G | ASN175 | |
| G | LEU216 | |
| G | PHE227 | |
| G | PHE244 | |
| G | TYR336 | |
| H | PHE171 | |
| E | ASN175 | |
| H | ASN175 | |
| H | LEU216 | |
| H | PHE227 | |
| H | PHE244 | |
| H | TYR336 | |
| E | LEU216 | |
| E | PHE227 | |
| E | PHE244 | |
| E | TYR336 | |
| F | PHE171 | |
| F | ASN175 | |
| F | LEU216 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER259 | |
| B | SER259 | |
| C | SER259 | |
| D | SER259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| A | SER260 | |
| B | SER260 | |
| C | SER260 | |
| D | SER260 |
