1XLS

Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
B	0003677	molecular_function	DNA binding
B	0003707	molecular_function	nuclear steroid receptor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
C	0003677	molecular_function	DNA binding
C	0003707	molecular_function	nuclear steroid receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
D	0003677	molecular_function	DNA binding
D	0003707	molecular_function	nuclear steroid receptor activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0004879	molecular_function	nuclear receptor activity
F	0006355	biological_process	regulation of DNA-templated transcription
G	0003677	molecular_function	DNA binding
G	0004879	molecular_function	nuclear receptor activity
G	0006355	biological_process	regulation of DNA-templated transcription
H	0003677	molecular_function	DNA binding
H	0004879	molecular_function	nuclear receptor activity
H	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 9CR A 801

Chain	Residue
A	ILE268
A	ALA327
A	HIS435
A	LEU436
A	ALA271
A	ALA272
A	GLN275
A	TRP305
A	LEU309
A	PHE313
A	ARG316
A	LEU326

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 9CR B 802

Chain	Residue
B	ILE268
B	ALA271
B	ALA272
B	GLN275
B	TRP305
B	LEU309
B	PHE313
B	ARG316
B	LEU326
B	ALA327
B	HIS435
B	LEU436

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 9CR C 803

Chain	Residue
C	ILE268
C	ALA271
C	ALA272
C	GLN275
C	TRP305
C	LEU309
C	PHE313
C	ARG316
C	LEU326
C	ALA327
C	HIS435
C	LEU436

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 9CR D 804

Chain	Residue
D	ILE268
D	ALA271
D	ALA272
D	GLN275
D	LEU309
D	PHE313
D	ARG316
D	LEU326
D	ALA327
D	HIS435
D	LEU436

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TCD E 805

Chain	Residue
E	PHE142
E	ASN175
E	LEU216
E	PHE227
E	CYS229
E	TYR234
E	PHE244
E	PHE248
E	ILE252
E	TYR336
E	GLU339
E	LEU340
E	LEU346
E	THR350
E	LEU353

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE TCD F 806

Chain	Residue
F	HOH88
F	PHE142
F	ASN175
F	LEU216
F	PHE227
F	CYS229
F	TYR234
F	PHE244
F	PHE248
F	ILE252
F	TYR336
F	GLU339
F	LEU340
F	LEU346
F	THR350
F	LEU353

---

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TCD G 807

Chain	Residue
G	PHE142
G	ASN175
G	LEU216
G	PHE227
G	CYS229
G	TYR234
G	PHE244
G	PHE248
G	ILE252
G	TYR336
G	GLU339
G	LEU340
G	LEU346
G	THR350
G	LEU353

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TCD H 808

Chain	Residue
H	PHE244
H	PHE248
H	ILE252
H	TYR336
H	GLU339
H	LEU340
H	LEU346
H	THR350
H	LEU353
H	PHE142
H	ASN175
H	LEU216
H	PHE227
H	CYS229
H	TYR234

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1880
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"source":"UniProtKB","id":"P28700","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Site: {"description":"Important for TCPOBOP recognition"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	32
Details	Motif: {"description":"LXXLL motif 3"}

Chain

Residue

Details

---