4QHO
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with CCO10
Summary for 4QHO
Entry DOI | 10.2210/pdb4qho/pdb |
Related | 3LFM 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7 |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, N-{[3-hydroxy-6-(naphthalen-1-yl)pyridin-2-yl]carbonyl}glycine, ... (4 entities in total) |
Functional Keywords | jelly-roll motif, oxidoreductase, dioxygenase, double-stranded beta helix fold, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q9C0B1 |
Total number of polymer chains | 1 |
Total formula weight | 57210.77 |
Authors | Aik, W.S.,Clunie-O'Connor, C.,McDonough, M.A.,Schofield, C.J. (deposition date: 2014-05-28, release date: 2015-06-03, Last modification date: 2023-11-08) |
Primary citation | Shishodia, S.,Demetriades, M.,Zhang, D.,Tam, N.Y.,Maheswaran, P.,Clunie-O'Connor, C.,Tumber, A.,Leung, I.K.H.,Ng, Y.M.,Leissing, T.M.,El-Sagheer, A.H.,Salah, E.,Brown, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J. Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J.Med.Chem., 64:16609-16625, 2021 Cited by PubMed: 34762429DOI: 10.1021/acs.jmedchem.1c01204 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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