4QHO

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with CCO10

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001659	biological_process	temperature homeostasis
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006307	biological_process	DNA alkylation repair
A	0008198	molecular_function	ferrous iron binding
A	0010883	biological_process	regulation of lipid storage
A	0016180	biological_process	snRNA processing
A	0016491	molecular_function	oxidoreductase activity
A	0016607	cellular_component	nuclear speck
A	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
A	0016740	molecular_function	transferase activity
A	0035515	molecular_function	oxidative RNA demethylase activity
A	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
A	0040014	biological_process	regulation of multicellular organism growth
A	0042245	biological_process	RNA repair
A	0044065	biological_process	regulation of respiratory system process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0060612	biological_process	adipose tissue development
A	0061157	biological_process	mRNA destabilization
A	0070350	biological_process	regulation of white fat cell proliferation
A	0090335	biological_process	regulation of brown fat cell differentiation
A	1990931	molecular_function	mRNA N6-methyladenosine dioxygenase activity
A	1990984	molecular_function	tRNA demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	HIS231
A	ASP233
A	HIS307
A	NKG602
A	HOH723

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NKG A 602

Chain	Residue
A	LEU203
A	ASN205
A	VAL228
A	HIS231
A	ASP233
A	GLU234
A	VAL244
A	TYR295
A	HIS307
A	VAL309
A	ARG316
A	SER318
A	THR320
A	ARG322
A	ZN601
A	HOH723
A	ARG96
A	TYR106
A	TYR108
A	LEU109

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Region: {"description":"Loop L1; predicted to block binding of double-stranded DNA or RNA","evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23547775","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28553460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23547775","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28553460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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