8E98
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![BU of 8e98 by Molmil](/molmil-images/mine/8e98) | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2022-08-26 | Release date: | 2022-12-07 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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8E9B
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![BU of 8e9b by Molmil](/molmil-images/mine/8e9b) | |
8E8Y
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![BU of 8e8y by Molmil](/molmil-images/mine/8e8y) | 9H2 Fab-Sabin poliovirus 2 complex | Descriptor: | 9H2 Fab heavy chain, 9H2 Fab light chain, Capsid protein VP1, ... | Authors: | Charnesky, A.J. | Deposit date: | 2022-08-26 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes. Nat Commun, 14, 2023
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8E8X
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![BU of 8e8x by Molmil](/molmil-images/mine/8e8x) | 9H2 Fab-Sabin poliovirus 3 complex | Descriptor: | 9H2 Fab heavy chain, 9H2 Fab light chain, Capsid protein VP1, ... | Authors: | Charnesky, A.J. | Deposit date: | 2022-08-26 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes. Nat Commun, 14, 2023
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8E8Z
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![BU of 8e8z by Molmil](/molmil-images/mine/8e8z) | 9H2 Fab-Sabin poliovirus 1 complex | Descriptor: | 9H2 Fab heavy chain, 9H2 Fab light chain, Capsid protein VP1, ... | Authors: | Charnesky, A.J. | Deposit date: | 2022-08-26 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes. Nat Commun, 14, 2023
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8AV6
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![BU of 8av6 by Molmil](/molmil-images/mine/8av6) | CryoEM structure of INO80 core nucleosome complex in closed grappler conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DASH complex subunit DAD4, ... | Authors: | Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P. | Deposit date: | 2022-08-26 | Release date: | 2022-12-14 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (4.68 Å) | Cite: | Structural mechanism of extranucleosomal DNA readout by the INO80 complex. Sci Adv, 8, 2022
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8AVD
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![BU of 8avd by Molmil](/molmil-images/mine/8avd) | Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement) | Descriptor: | Leptin, Leptin receptor, NICKEL (II) ION | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVO
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![BU of 8avo by Molmil](/molmil-images/mine/8avo) | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model). | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (6.84 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVF
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![BU of 8avf by Molmil](/molmil-images/mine/8avf) | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model) | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (6.45 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVC
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![BU of 8avc by Molmil](/molmil-images/mine/8avc) | Mouse leptin:LEP-R complex cryoEM structure (3:3 model) | Descriptor: | Leptin, Leptin receptor, NICKEL (II) ION | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVN
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![BU of 8avn by Molmil](/molmil-images/mine/8avn) | Mutant of Superoxide dismutase SodFM1 from CPR Parcubacteria Wolfebacteria | Descriptor: | MANGANESE (II) ION, Superoxide dismutase | Authors: | Basle, A, Barwinska-Sendra, A, Sendra, K.M, Waldron, K. | Deposit date: | 2022-08-26 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | An ancient metalloenzyme evolves through metal preference modulation. Nat Ecol Evol, 7, 2023
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8AV1
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![BU of 8av1 by Molmil](/molmil-images/mine/8av1) | Crystal structure of GSK3 beta (GSK3b) in complex with CD7. | Descriptor: | 1,2-ETHANEDIOL, 2-pyridin-3-yl-8-thiomorpholin-4-yl-[1,3]oxazolo[5,4-f]quinoxaline, Glycogen synthase kinase-3 beta, ... | Authors: | Chaikuad, A, Mongin, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2022-08-26 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3 alpha (GSK-3 alpha ): Development and impact on temozolomide treatment of glioblastoma cells. Bioorg.Chem., 134, 2023
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8AVE
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![BU of 8ave by Molmil](/molmil-images/mine/8ave) | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model) | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (5.62 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AUZ
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![BU of 8auz by Molmil](/molmil-images/mine/8auz) | Crystal structure of GSK3 beta (GSK3b) in complex with FL291. | Descriptor: | 8-morpholin-4-yl-2-pyridin-3-yl-[1,3]oxazolo[5,4-f]quinoxaline, Glycogen synthase kinase-3 beta, SULFATE ION | Authors: | Chaikuad, A, Mongin, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2022-08-26 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3 alpha (GSK-3 alpha ): Development and impact on temozolomide treatment of glioblastoma cells. Bioorg.Chem., 134, 2023
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8AVK
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![BU of 8avk by Molmil](/molmil-images/mine/8avk) | Superoxide dismutase SodFM1 from CPR Parkubacteria Wolfebacteria | Descriptor: | FE (III) ION, Superoxide dismutase | Authors: | Basle, A, Barwinska-Sendra, A, Sendra, K.M, Waldron, K. | Deposit date: | 2022-08-26 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An ancient metalloenzyme evolves through metal preference modulation. Nat Ecol Evol, 7, 2023
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8AVM
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![BU of 8avm by Molmil](/molmil-images/mine/8avm) | Mutant of Superoxide Dismutase sodfm2 from Bacteroides fragilis | Descriptor: | FE (III) ION, Superoxide dismutase [Fe] | Authors: | Basle, A, Barwinska-Sendra, A, Sendra, K.M, Waldron, K. | Deposit date: | 2022-08-26 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An ancient metalloenzyme evolves through metal preference modulation. Nat Ecol Evol, 7, 2023
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8AVL
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![BU of 8avl by Molmil](/molmil-images/mine/8avl) | Superoxide dismutase SodFM2 from Bacteroides fragilis | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, Superoxide dismutase [Fe] | Authors: | Basle, A, Barwinska-Sendra, A, Sendra, K.M, Waldron, K. | Deposit date: | 2022-08-26 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | An ancient metalloenzyme evolves through metal preference modulation. Nat Ecol Evol, 7, 2023
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8AVB
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![BU of 8avb by Molmil](/molmil-images/mine/8avb) | Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model). | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8E83
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![BU of 8e83 by Molmil](/molmil-images/mine/8e83) | |
8E80
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![BU of 8e80 by Molmil](/molmil-images/mine/8e80) | Structure of LRRK2-CHK1 10-pt. mutant complex with heteroaryl-1H-indazole LRRK2 inhibitor 14 | Descriptor: | 2-[(1r,4r)-2-{(6P)-6-[(6M)-6-(1H-pyrazol-5-yl)-1H-indazol-1-yl]pyrimidin-4-yl}-2-azabicyclo[2.1.1]hexan-4-yl]propan-2-ol, Serine/threonine-protein kinase Chk1 | Authors: | Palte, R.L. | Deposit date: | 2022-08-25 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J.Med.Chem., 65, 2022
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8E81
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![BU of 8e81 by Molmil](/molmil-images/mine/8e81) | Structure of LRRK2-CHK1 10-pt. mutant complex with heteroaryl-1H-indazole LRRK2 inhibitor 25 | Descriptor: | (1S)-1-[(1P)-1-{6-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]pyrimidin-4-yl}-1H-indazol-6-yl]spiro[2.2]pentane-1-carbonitrile, Serine/threonine-protein kinase Chk1 | Authors: | Palte, R.L. | Deposit date: | 2022-08-25 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J.Med.Chem., 65, 2022
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8E8R
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![BU of 8e8r by Molmil](/molmil-images/mine/8e8r) | 9H2 Fab-Sabin poliovirus 3 complex | Descriptor: | 9H2 Fab heavy chain, 9H2 Fab light chain, Capsid protein VP1, ... | Authors: | Charnesky, A.J. | Deposit date: | 2022-08-25 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes. Nat Commun, 14, 2023
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8E8L
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![BU of 8e8l by Molmil](/molmil-images/mine/8e8l) | 9H2 Fab-poliovirus 1 complex | Descriptor: | 9H2 Fab heavy chain, 9H2 Fab light chain, Capsid protein VP1, ... | Authors: | Charnesky, A.J. | Deposit date: | 2022-08-25 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes. Nat Commun, 14, 2023
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8E8S
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![BU of 8e8s by Molmil](/molmil-images/mine/8e8s) | 9H2 Fab-poliovirus 2 complex | Descriptor: | 9H2 Fab heavy chain, 9H2 Fab light chain, Capsid protein VP1, ... | Authors: | Charnesky, A.J. | Deposit date: | 2022-08-25 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes. Nat Commun, 14, 2023
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8E7S
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![BU of 8e7s by Molmil](/molmil-images/mine/8e7s) | III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | Descriptor: | (5S,11R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-diphosphaoctadec-1-yl pentadecanoate, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... | Authors: | Hryc, C.F, Mileykovskaya, E, Baker, M, Dowhan, W. | Deposit date: | 2022-08-24 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex. Nat Commun, 14, 2023
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