5EAH
 
 | | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Difenoconazole | | Descriptor: | 1-[[(2~{R},4~{R})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole, 1-[[(2~{R},4~{S})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole, 1-[[(2~{S},4~{R})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole, ... | | Authors: | Tyndall, J.D.A, Sabherwal, M, Keniya, M.V, Wilson, R.K, Woods, M.V, Monk, B.C. | | Deposit date: | 2015-10-16 | | Release date: | 2016-02-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.541 Å) | | Cite: | Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals.
PLoS ONE, 11, 2016
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4ZYF
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2PFY
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5BYI
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1ID8
 | | NMR STRUCTURE OF GLUTAMATE MUTASE (B12-BINDING SUBUNIT) COMPLEXED WITH THE VITAMIN B12 NUCLEOTIDE | | Descriptor: | 2-HYDROXY-PROPYL-AMMONIUM, METHYLASPARTATE MUTASE S CHAIN, PHOSPHORIC ACID MONO-[5-(5,6-DIMETHYL-BENZOIMIDAZOL-1-YL)-4-HYDROXY-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-YL] ESTER | | Authors: | Tollinger, M, Eichmuller, C, Konrat, R, Huhta, M.S, Marsh, E.N.G, Krautler, B. | | Deposit date: | 2001-04-04 | | Release date: | 2001-06-27 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The B(12)-binding subunit of glutamate mutase from Clostridium tetanomorphum traps the nucleotide moiety of coenzyme B(12).
J.Mol.Biol., 309, 2001
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5AG7
 | | CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINE LIGAND | | Descriptor: | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, ethyl (3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetate | | Authors: | Robinson, D.A, Spinks, D, Smith, V.C, Thompson, S, Smith, A, Torrie, L.S, McElroy, S.P, Brand, S, Brenk, R, Frearson, J.A, Read, K.D, Wyatt, P.G, Gilbert, I.H. | | Deposit date: | 2015-01-29 | | Release date: | 2015-10-07 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Chemmedchem, 10, 2015
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5ZBB
 | | Crystal structure of Rtt109-Asf1-H3-H4 complex | | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA damage response protein Rtt109, putative, ... | | Authors: | Zhang, L, Serra-Cardona, A, Zhou, H, Wang, M, Yang, N, Zhang, Z, Xu, R.M. | | Deposit date: | 2018-02-10 | | Release date: | 2018-07-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.
Cell, 174, 2018
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5WGD
 | | Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1 | | Descriptor: | (ACE)AILHKLLQDS(NH2), (ACE)HKILHKLLQDS(NH2), ESTRADIOL, ... | | Authors: | Fanning, S.W, Speltz, T.E, Mayne, C.G, Siddiqui, Z, Greene, G.L, Tajkhorshid, E, Moore, T.W. | | Deposit date: | 2017-07-14 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A "cross-stitched" peptide with improved helicity and proteolytic stability.
Org. Biomol. Chem., 16, 2018
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3GI1
 | | Crystal Structure of the laminin-binding protein Lbp of Streptococcus pyogenes | | Descriptor: | Laminin-binding protein of group A streptococci, ZINC ION | | Authors: | Linke, C, Caradoc-Davies, T.T, Young, P.G, Proft, T, Baker, E.N. | | Deposit date: | 2009-03-04 | | Release date: | 2009-08-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor
J.Bacteriol., 191, 2009
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7KBW
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2JTT
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1YPP
 | | ACID ANHYDRIDE HYDROLASE | | Descriptor: | INORGANIC PYROPHOSPHATASE, MANGANESE (II) ION, PHOSPHATE ION | | Authors: | Harutyunyan, E.H, Kuranova, I.P, Lamzin, V.S, Dauter, Z, Wilson, K.S. | | Deposit date: | 1996-05-29 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | X-ray structure of yeast inorganic pyrophosphatase complexed with manganese and phosphate.
Eur.J.Biochem., 239, 1996
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4J47
 | | Crystal structure of XIAP-BIR2 domain with SVPI bound | | Descriptor: | E3 ubiquitin-protein ligase XIAP, PEPTIDE (SER-VAL-PRO-ILE), ZINC ION | | Authors: | Lukacs, C.M, Janson, C.A. | | Deposit date: | 2013-02-06 | | Release date: | 2013-09-25 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013
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4J3Y
 | | Crystal structure of XIAP-BIR2 domain | | Descriptor: | E3 ubiquitin-protein ligase XIAP, ZINC ION | | Authors: | Lukacs, C.M, Janson, C.A. | | Deposit date: | 2013-02-06 | | Release date: | 2013-09-25 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013
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7E4P
 | | Crystal structure of tubulin in complex with Ansamitocin P3 | | Descriptor: | (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Li, W. | | Deposit date: | 2021-02-14 | | Release date: | 2022-02-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids
To Be Published
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7E4Y
 | | Crystal structure of tubulin in complex with L-DM4-SMe | | Descriptor: | (1S,2S,3S,5R,6S,16E,18E,20S,21R)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-methyl-3-(methyldisulfanyl)butanoyl]amino}propanoate (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Li, W. | | Deposit date: | 2021-02-16 | | Release date: | 2022-02-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.708 Å) | | Cite: | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids
To Be Published
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1I5Y
 | | HIV-1 GP41 CORE | | Descriptor: | SULFATE ION, TRANSMEMBRANE GLYCOPROTEIN (GP41) | | Authors: | Liu, J, Lu, M. | | Deposit date: | 2001-03-01 | | Release date: | 2002-09-10 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and functional analysis of interhelical interactions in the human
immunodeficiency virus type 1 gp41 envelope glycoprotein by alanine-scanning
mutagenesis.
J.Virol., 75, 2001
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3W7Z
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1I6O
 | | CRYSTAL STRUCTURE OF E. COLI BETA CARBONIC ANHYDRASE (ECCA) | | Descriptor: | CARBONIC ANHYDRASE, ZINC ION | | Authors: | Cronk, J.D, Endrizzi, J.A, Cronk, M.R, O'Neill, J.W, Zhang, K.Y.J. | | Deposit date: | 2001-03-02 | | Release date: | 2001-05-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity.
Protein Sci., 10, 2001
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5EAE
 | | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor R-desthio-prothioconazole | | Descriptor: | (2~{R})-2-(1-chloranylcyclopropyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Tyndall, J.D.A, Sabherwal, M, Sagatova, A.A, Keniya, M.V, Wilson, R.K, Woods, M.V, Monk, B.C. | | Deposit date: | 2015-10-16 | | Release date: | 2016-02-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals.
PLoS ONE, 11, 2016
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4N14
 | | Crystal structure of Cdc20 and apcin complex | | Descriptor: | 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl [(1R)-2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate, Cell division cycle protein 20 homolog | | Authors: | Luo, X, Tian, W, Yu, H. | | Deposit date: | 2013-10-03 | | Release date: | 2014-08-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Nature, 514, 2014
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4HXI
 | | Crystal structure of KLHL3/Cul3 complex | | Descriptor: | Cullin-3, Kelch-like protein 3 | | Authors: | Ji, A.X, Prive, G.G. | | Deposit date: | 2012-11-10 | | Release date: | 2013-03-13 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.513 Å) | | Cite: | Crystal structure of KLHL3 in complex with Cullin3.
Plos One, 8, 2013
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1G6B
 | | CRYSTAL STRUCTURE OF P47S MUTANT OF FERREDOXIN I | | Descriptor: | 7FE FERREDOXIN I, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER | | Authors: | Stout, C.D, Burgess, B.K, Bonagura, C.A, Jung, Y.S. | | Deposit date: | 2000-11-03 | | Release date: | 2000-11-22 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Azotobacter vinelandii ferredoxin I: a sequence and structure comparison approach to alteration of [4Fe-4S]2+/+ reduction potential.
J.Biol.Chem., 277, 2002
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7EMJ
 | | Crystal structure of T2R-TTL-Barbigerone complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one, CALCIUM ION, ... | | Authors: | Yang, J.H, Yan, W. | | Deposit date: | 2021-04-14 | | Release date: | 2022-04-20 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton.
Phytomedicine, 109, 2023
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3HGS
 | | Crystal structure of tomato OPR3 in complex with pHB | | Descriptor: | 12-oxophytodienoate reductase 3, FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZOIC ACID | | Authors: | Clausen, T, Breithaupt, C. | | Deposit date: | 2009-05-14 | | Release date: | 2009-08-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of substrate specificity of plant 12-oxophytodienoate reductases.
J.Mol.Biol., 392, 2009
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