7KBW

Solution structure of the major MYC promoter G-quadruplex with a wild-type flanking in complex with NSC85697, a quinoline derivative

Summary for 7KBW

• Entry DOI: 10.2210/pdb7kbw/pdb
• Related: 7KBV
• NMR Information: BMRB: 30804
• Descriptor: Myc2345, 2-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]-1-methyl-quinoline-4-carboxamide (2 entities in total)
• Functional Keywords: g-quadruplex dna, drug-dna complex, dna
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 7704.27

Authors

Dickerhoff, J.,Yang, D. (deposition date: 2020-10-03, release date: 2021-06-23, Last modification date: 2024-05-01)

• Primary citation: Dickerhoff, J.,Dai, J.,Yang, D.; Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes.; Nucleic Acids Res., 49:5905-5915, 2021; PubMed: 33978746; DOI: 10.1093/nar/gkab330

Experimental method

SOLUTION NMR