4N14
Crystal structure of Cdc20 and apcin complex
Summary for 4N14
Entry DOI | 10.2210/pdb4n14/pdb |
Related | 4GGA 4GGC 4GGD |
Descriptor | Cell division cycle protein 20 homolog, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl [(1R)-2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate (3 entities in total) |
Functional Keywords | cell cycle, mitosis, securin, ubiquitination, wd40, cell cycle-cell cycle inhibitor complex, cell cycle/cell cycle inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q12834 |
Total number of polymer chains | 1 |
Total formula weight | 34876.21 |
Authors | |
Primary citation | Sackton, K.L.,Dimova, N.,Zeng, X.,Tian, W.,Zhang, M.,Sackton, T.B.,Meaders, J.,Pfaff, K.L.,Sigoillot, F.,Yu, H.,Luo, X.,King, R.W. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature, 514:646-649, 2014 Cited by PubMed: 25156254DOI: 10.1038/nature13660 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report