7NU4
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![BU of 7nu4 by Molmil](/molmil-images/mine/7nu4) | Crystal Structure of Neisseria gonorrhoeae LeuRS | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU7
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![BU of 7nu7 by Molmil](/molmil-images/mine/7nu7) | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP in Conformation 2 | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Leucine--tRNA ligase, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NUC
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![BU of 7nuc by Molmil](/molmil-images/mine/7nuc) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550G mutant in Complex with ATP and L-leucinol | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NTZ
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![BU of 7ntz by Molmil](/molmil-images/mine/7ntz) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550A mutant in Complex with the Reaction Intermediate Leu-AMP | Descriptor: | Leucine--tRNA ligase, MAGNESIUM ION, ZINC ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU3
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![BU of 7nu3 by Molmil](/molmil-images/mine/7nu3) | Crystal Structure of Neisseria gonorrhoeae LeuRS E169G mutant in Complex with ATP and L-leucinol | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NUA
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![BU of 7nua by Molmil](/molmil-images/mine/7nua) | |
7NUB
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![BU of 7nub by Molmil](/molmil-images/mine/7nub) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550G mutant in Complex with the Reaction Intermediate Leu-AMP | Descriptor: | Leucine--tRNA ligase, MAGNESIUM ION, ZINC ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU0
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![BU of 7nu0 by Molmil](/molmil-images/mine/7nu0) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550A mutant in Complex with ATP and L-leucinol | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-09-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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8UH1
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![BU of 8uh1 by Molmil](/molmil-images/mine/8uh1) | |
2V5B
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![BU of 2v5b by Molmil](/molmil-images/mine/2v5b) | |
4P8R
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![BU of 4p8r by Molmil](/molmil-images/mine/4p8r) | |
4PL9
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![BU of 4pl9 by Molmil](/molmil-images/mine/4pl9) | |
2VZ0
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![BU of 2vz0 by Molmil](/molmil-images/mine/2vz0) | Pteridine Reductase 1 (PTR1) from Trypanosoma Brucei in complex with NADP and DDD00066641 | Descriptor: | 6-(4-methylphenyl)quinazoline-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | Authors: | Robinson, D.A, Thompson, S, Sienkiewicz, N, Fairlamb, A.H. | Deposit date: | 2008-07-29 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Development and Validation of a Cytochrome C Coupled Assay for Pteridine Reductase 1 and Dihydrofolate Reductase. Anal.Biochem., 396, 2010
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4QT0
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![BU of 4qt0 by Molmil](/molmil-images/mine/4qt0) | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 1, 3-{[3-CARBAMOYL-7-(2,4-DIMETHOXYPYRIMIDIN-5-YL)QUINOLIN-4-YL]AMINO}BENZOIC ACID | Descriptor: | 3-{[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}benzoic acid, L-lactate dehydrogenase A chain | Authors: | Kolappan, S, Craig, L. | Deposit date: | 2014-07-06 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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4QSM
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![BU of 4qsm by Molmil](/molmil-images/mine/4qsm) | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid | Descriptor: | 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid, L-lactate dehydrogenase A chain | Authors: | Kolappan, S, Craig, L. | Deposit date: | 2014-07-06 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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5H2R
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![BU of 5h2r by Molmil](/molmil-images/mine/5h2r) | Crystal structure of T brucei phosphodiesterase B2 bound to compound 15b | Descriptor: | (4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-(2-hydroxyethyloxy)-3-[2-(2-oxidanylideneimidazolidin-1-yl)ethoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one, MAGNESIUM ION, Phosphodiesterase, ... | Authors: | Noble, C.G. | Deposit date: | 2016-10-17 | Release date: | 2017-11-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Trypanosomal Phosphodiesterase B1 and B2 as a Potential Therapy for Human African Trypanosomiasis To Be Published
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5H2Q
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![BU of 5h2q by Molmil](/molmil-images/mine/5h2q) | Crystal structure of T brucei phosphodiesterase B2 bound to compound 13e | Descriptor: | (4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-methoxy-3-[2-(2-oxidanylideneimidazolidin-1-yl)ethoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one, MAGNESIUM ION, Phosphodiesterase, ... | Authors: | Noble, C.G. | Deposit date: | 2016-10-17 | Release date: | 2017-11-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Trypanosomal Phosphodiesterase B1 and B2 as a Potential Therapy for Human African Trypanosomiasis To Be Published
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1QOP
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![BU of 1qop by Molmil](/molmil-images/mine/1qop) | |
9FEE
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![BU of 9fee by Molmil](/molmil-images/mine/9fee) | Cryo-EM structure of Trypanosoma cruzi glycosomal malate dehydrogenase | Descriptor: | malate dehydrogenase | Authors: | Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G. | Deposit date: | 2024-05-19 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Cryo-EM structure of Trypanosoma cruzi glycosomal malate dehydrogenase To Be Published
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9FEF
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![BU of 9fef by Molmil](/molmil-images/mine/9fef) | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex | Descriptor: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | Authors: | Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G. | Deposit date: | 2024-05-19 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex To Be Published
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4GAA
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![BU of 4gaa by Molmil](/molmil-images/mine/4gaa) | Structure of Leukotriene A4 hydrolase from Xenopus laevis complexed with inhibitor bestatin | Descriptor: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, MGC78867 protein, ZINC ION | Authors: | Stsiapanava, A, Kumar, R.B, Haeggstrom, J.Z, Rinaldo-Matthis, A. | Deposit date: | 2012-07-25 | Release date: | 2013-06-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Product formation controlled by substrate dynamics in leukotriene A4 hydrolase. Biochim.Biophys.Acta, 1844, 2014
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2MYG
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![BU of 2myg by Molmil](/molmil-images/mine/2myg) | Solution structure of the dithiolic glutaredoxin 2-C-Grx1 from the pathogen Trypanosoma brucei brucei | Descriptor: | Dithiol glutaredoxin 1 | Authors: | Sturlese, M, Stefani, M, Manta, B, Mammi, S, Comini, M, Bellanda, M. | Deposit date: | 2015-01-22 | Release date: | 2016-02-10 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the dithiolic glutaredoxin 2-C-Grx1 from the pathogen Trypanosoma brucei brucei To be Published
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7DDP
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![BU of 7ddp by Molmil](/molmil-images/mine/7ddp) | Cryo-EM structure of human ACE2 and GX/P2V/2017 RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | Authors: | Niu, S, Wang, J, Wang, H.W, Qi, J.X, Wang, Q.H, Gao, G.F. | Deposit date: | 2020-10-29 | Release date: | 2021-05-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. Embo J., 40, 2021
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7DDO
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![BU of 7ddo by Molmil](/molmil-images/mine/7ddo) | Cryo-EM structure of human ACE2 and GD/1/2019 RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | Authors: | Niu, S, Wang, J, Wang, H.W, Qi, J.X, Wang, Q.H, Gao, G.F. | Deposit date: | 2020-10-29 | Release date: | 2021-05-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. Embo J., 40, 2021
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7E7M
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![BU of 7e7m by Molmil](/molmil-images/mine/7e7m) | |