8JZM
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![BU of 8jzm by Molmil](/molmil-images/mine/8jzm) | The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210 | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Rahaman, M.H, Jia, X, Maxwell, M.J, Mobli, M, Kobe, B. | Deposit date: | 2023-07-05 | Release date: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. J Enzyme Inhib Med Chem, 39, 2024
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6GOS
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![BU of 6gos by Molmil](/molmil-images/mine/6gos) | E. coli Microcin synthetase McbBCD complex with pro-MccB17 bound | Descriptor: | 1,2-ETHANEDIOL, Bacteriocin microcin B17, CHLORIDE ION, ... | Authors: | Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. | Deposit date: | 2018-06-04 | Release date: | 2019-01-30 | Last modified: | 2019-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
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6GRI
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![BU of 6gri by Molmil](/molmil-images/mine/6gri) | E. coli Microcin synthetase McbBCD complex | Descriptor: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, Microcin B17-processing protein McbB, ... | Authors: | Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K. | Deposit date: | 2018-06-11 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Mol. Cell, 73, 2019
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2LSM
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![BU of 2lsm by Molmil](/molmil-images/mine/2lsm) | Solution structure of gpFI C-terminal domain | Descriptor: | DNA-packaging protein FI | Authors: | Popovic, A, Wu, B, Edwards, A.M, Davidson, A.R, Maxwell, K.L. | Deposit date: | 2012-05-02 | Release date: | 2012-07-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and biochemical characterization of phage lambda FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity. J.Biol.Chem., 287, 2012
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6FQM
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![BU of 6fqm by Molmil](/molmil-images/mine/6fqm) | 3.06A COMPLEX OF S.AUREUS GYRASE with imidazopyrazinone T1 AND DNA | Descriptor: | 7-[(3~{S})-3-azanylpyrrolidin-1-yl]-5-cyclopropyl-8-fluoranyl-imidazo[1,2-a]quinoxalin-4-one, DNA (5'-D(*GP*AP*GP*AP*GP*TP*AP*T*GP*GP*CP*CP*AP*TP*AP*CP*TP*CP*T)-3'), DNA gyrase subunit A, ... | Authors: | Bax, B.D, Germe, T, Basque, E, Maxwell, A. | Deposit date: | 2018-02-14 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res., 46, 2018
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6FQV
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![BU of 6fqv by Molmil](/molmil-images/mine/6fqv) | 2.60A BINARY COMPLEX OF S.AUREUS GYRASE with UNCLEAVED DNA | Descriptor: | DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*T)-3'), DNA gyrase subunit A, DNA gyrase subunit B,DNA gyrase subunit B, ... | Authors: | Bax, B.D, Germe, T, Basque, E, Maxwell, A. | Deposit date: | 2018-02-14 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res., 46, 2018
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6N05
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![BU of 6n05 by Molmil](/molmil-images/mine/6n05) | Structure of anti-crispr protein, AcrIIC2 | Descriptor: | AcrIIC2 | Authors: | Shah, M, Thavalingham, A, Maxwell, K.L, Moraes, T.F. | Deposit date: | 2018-11-06 | Release date: | 2019-06-05 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nat Commun, 10, 2019
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2L04
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![BU of 2l04 by Molmil](/molmil-images/mine/2l04) | The Solution Structure of the C-terminal Ig-like Domain of the Bacteriophage Lambda Tail Tube Protein | Descriptor: | Major tail protein V | Authors: | Pell, L.G, Gasmi-Seabrook, G.M.C, Donaldson, L.W, Howell, P, Davidson, A.R, Maxwell, K.L. | Deposit date: | 2010-06-30 | Release date: | 2010-09-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The Solution Structure of the C-Terminal Ig-like Domain of the Bacteriophage l Tail Tube Protein. J.Mol.Biol., 403, 2010
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1Z1Z
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![BU of 1z1z by Molmil](/molmil-images/mine/1z1z) | |
5UZ9
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![BU of 5uz9 by Molmil](/molmil-images/mine/5uz9) | Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex | Descriptor: | Anti-CRISPR protein 30, Anti-CRISPR protein Acr30-35, CRISPR RNA (60-MER), ... | Authors: | Chowdhury, S, Carter, J, Rollins, M.F, Jackson, R.N, Hoffmann, C, Nosaka, L, Bondy-Denomy, J, Maxwell, K.L, Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B. | Deposit date: | 2017-02-25 | Release date: | 2017-04-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell, 169, 2017
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7JHD
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![BU of 7jhd by Molmil](/molmil-images/mine/7jhd) | Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with TTC-352 and GRIP Peptide | Descriptor: | 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophene-6-ol, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Fanning, S.W, Abderraman, B, Maximov, P.Y, Jordan, V.C, Greene, G.L. | Deposit date: | 2020-07-20 | Release date: | 2020-11-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol.Cancer Ther., 20, 2021
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6AS4
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![BU of 6as4 by Molmil](/molmil-images/mine/6as4) | Structure of a phage anti-CRISPR protein | Descriptor: | NHis AcrE1 anti-crispr protein | Authors: | Shah, M, Calmettes, C, Pawluk, A, Mejdani, M, Davidson, A.R, Maxwell, K.L, Moraes, T.F. | Deposit date: | 2017-08-23 | Release date: | 2017-12-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein. MBio, 8, 2017
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6AS3
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![BU of 6as3 by Molmil](/molmil-images/mine/6as3) | Structure of a phage anti-CRISPR protein | Descriptor: | NHis AcrE1 protein | Authors: | Shah, M, Calmettes, C, Pawluk, A, Mejdani, M, Davidson, A.R, Maxwell, K.L, Moraes, T.F. | Deposit date: | 2017-08-23 | Release date: | 2018-08-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein. MBio, 8, 2017
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7KIX
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![BU of 7kix by Molmil](/molmil-images/mine/7kix) | |
1ZPQ
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![BU of 1zpq by Molmil](/molmil-images/mine/1zpq) | STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein | Descriptor: | Regulatory protein CII | Authors: | Jain, D, Kim, Y, Maxwell, K.L, Beasley, S, Gussin, G.N, Edwards, A.M, Joachimiak, A, Darst, S.A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-05-17 | Release date: | 2005-08-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Bacteriophage lambdacII and Its DNA Complex. Mol.Cell, 19, 2005
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1ZS4
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![BU of 1zs4 by Molmil](/molmil-images/mine/1zs4) | Structure of bacteriophage lambda cII protein in complex with DNA | Descriptor: | DNA - 27mer, Regulatory protein CII | Authors: | Jain, D, Kim, Y, Maxwell, K.L, Beasley, S, Gussin, G.N, Edwards, A.M, Darst, S.A. | Deposit date: | 2005-05-23 | Release date: | 2005-08-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of Bacteriophage lambdacII and Its DNA Complex. Mol.Cell, 19, 2005
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6F8J
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![BU of 6f8j by Molmil](/molmil-images/mine/6f8j) | Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-(1H-pyrazol-1-yl)-N-(pyridin-3-yl)pyridine-3-carboxamide | Descriptor: | 6-(ethylcarbamoylamino)-4-pyrazol-1-yl-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B | Authors: | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | Deposit date: | 2017-12-13 | Release date: | 2019-06-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
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6F96
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![BU of 6f96 by Molmil](/molmil-images/mine/6f96) | Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide | Descriptor: | 6-(ethylcarbamoylamino)-4-[(4-methoxyphenyl)amino]-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B | Authors: | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | Deposit date: | 2017-12-14 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
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6F86
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![BU of 6f86 by Molmil](/molmil-images/mine/6f86) | Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide | Descriptor: | 4-(4-bromanylpyrazol-1-yl)-6-(ethylcarbamoylamino)-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B | Authors: | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | Deposit date: | 2017-12-12 | Release date: | 2019-06-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
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6F94
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![BU of 6f94 by Molmil](/molmil-images/mine/6f94) | Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(3-methyphenyl)amino]-N-(3-methyphenyl)pyridine-3-carboxamide | Descriptor: | 6-(ethylcarbamoylamino)-~{N}-(3-methylphenyl)-4-[(3-methylphenyl)amino]pyridine-3-carboxamide, DNA gyrase subunit B | Authors: | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | Deposit date: | 2017-12-14 | Release date: | 2019-06-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg.Med.Chem., 27, 2019
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7M3P
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![BU of 7m3p by Molmil](/molmil-images/mine/7m3p) | Xrcc4-Spc110p(164-207) fusion | Descriptor: | Xrcc4-Spc110p(164-207) | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-18 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.0000186 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7M2Y
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![BU of 7m2y by Molmil](/molmil-images/mine/7m2y) | Closed conformation of the Yeast wild-type gamma-TuRC | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7M2X
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![BU of 7m2x by Molmil](/molmil-images/mine/7m2x) | Open conformation of the Yeast wild-type gamma-TuRC | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7M2Z
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![BU of 7m2z by Molmil](/molmil-images/mine/7m2z) | Monomeric single-particle reconstruction of the Yeast gamma-TuSC | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Spindle pole body component SPC97, Spindle pole body component SPC98, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7M2W
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![BU of 7m2w by Molmil](/molmil-images/mine/7m2w) | Engineered disulfide cross-linked closed conformation of the Yeast gamma-TuRC(SS) | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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