3V9T

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

Summary for 3V9T

Entry DOI	10.2210/pdb3v9t/pdb
Related	3B1M 3LMP 3V9V 3V9Y
Descriptor	Peroxisome proliferator-activated receptor gamma, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (9aS)-8-acetyl-N-[(3-ethoxynaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, ... (4 entities in total)
Functional Keywords	three-layered alpha-helical sandwich, transcription regulation, transcription-transcription regulator complex, transcription/transcription regulator
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P37231 Q9UBK2
Total number of polymer chains	2
Total formula weight	35009.49
Authors	Matsui, Y.,Hanzawa, H. (deposition date: 2011-12-28, release date: 2012-02-01, Last modification date: 2023-11-08)
Primary citation	Furukawa, A.,Arita, T.,Fukuzaki, T.,Satoh, S.,Mori, M.,Honda, T.,Matsui, Y.,Wakabayashi, K.,Hayashi, S.,Araki, K.,Ohsumi, J. Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR(gamma) partial agonists Bioorg.Med.Chem.Lett., 22:1348-1351, 2012 Cited by PubMed: 22225641 DOI: 10.1016/j.bmcl.2011.12.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation