8FTD
 
 | | Structure of Escherichia coli CedA in complex with transcription initiation complex | | Descriptor: | CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Liu, M, Vassyliev, N, Nudler, E. | | Deposit date: | 2023-01-11 | | Release date: | 2024-01-10 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | General transcription factor from Escherichia coli with a distinct mechanism of action.
Nat.Struct.Mol.Biol., 31, 2024
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6JNX
 | | Cryo-EM structure of a Q-engaged arrested complex | | Descriptor: | Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Feng, Y, Shi, J. | | Deposit date: | 2019-03-18 | | Release date: | 2019-06-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.08 Å) | | Cite: | Structural basis of Q-dependent transcription antitermination.
Nat Commun, 10, 2019
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8GZG
 | | Cryo-EM structure of Synechocystis sp. PCC 6803 RPitc | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Shen, L.Q, You, L.L, Zhang, Y. | | Deposit date: | 2022-09-27 | | Release date: | 2023-04-19 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc
Proc.Natl.Acad.Sci.USA, 2023
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8GZH
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8X6G
 | | Cryo-EM structure of Staphylococcus aureus sigB-dependent RNAP-promoter open complex | | Descriptor: | DNA (70-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Yuan, L, Xu, L, Liu, Q, Feng, Y. | | Deposit date: | 2023-11-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase.
Nat Commun, 15, 2024
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8X6F
 | | Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex | | Descriptor: | DNA (71-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Yuan, L, Xu, L, Liu, Q, Feng, Y. | | Deposit date: | 2023-11-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase.
Nat Commun, 15, 2024
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1RP3
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6K4Y
 | | CryoEM structure of sigma appropriation complex | | Descriptor: | 10 kDa anti-sigma factor, DNA (60-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Shi, J, Wen, A, Feng, Y. | | Deposit date: | 2019-05-27 | | Release date: | 2019-08-07 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structural basis of sigma appropriation.
Nucleic Acids Res., 47, 2019
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6KJ6
 | | cryo-EM structure of Escherichia coli Crl transcription activation complex | | Descriptor: | DNA (51-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Xu, J, Zhang, Y. | | Deposit date: | 2019-07-21 | | Release date: | 2020-01-01 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor.
Elife, 8, 2019
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1SMY
 | | Structural basis for transcription regulation by alarmone ppGpp | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | Authors: | Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-03-10 | | Release date: | 2004-05-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for transcription regulation by alarmone ppGpp
Cell(Cambridge,Mass.), 117, 2004
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7XYA
 | | The cryo-EM structure of an AlpA-loading complex | | Descriptor: | AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Wen, A, Feng, Y. | | Deposit date: | 2022-06-01 | | Release date: | 2022-07-20 | | Last modified: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of AlpA-dependent transcription antitermination.
Nucleic Acids Res., 50, 2022
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7XUI
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7P5X
 | | Mycobacterial RNAP with transcriptional activator PafBC | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. | | Deposit date: | 2021-07-15 | | Release date: | 2021-12-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Transcriptional control of mycobacterial DNA damage response by sigma adaptation.
Sci Adv, 7, 2021
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7YE1
 | | The cryo-EM structure of C. crescentus GcrA-TACup | | Descriptor: | Cell cycle regulatory protein GcrA, DNA (57-MER)-non template, DNA (57-MER)-template, ... | | Authors: | Wu, X.X, Zhang, Y. | | Deposit date: | 2022-07-05 | | Release date: | 2023-01-18 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structures of Caulobacter crescentus transcription activation complex with an essential cell cycle regulator GcrA
Nucleic Acids Res., 2023
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7YE2
 | | The cryo-EM structure of C. crescentus GcrA-TACdown | | Descriptor: | Cell cycle regulatory protein GcrA, DNA (90-MER)-non template, DNA (90-MER)-template, ... | | Authors: | Wu, X.X, Zhang, Y. | | Deposit date: | 2022-07-05 | | Release date: | 2023-01-18 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structures of Caulobacter crescentus transcription activation complex with an essential cell cycle regulator GcrA
Nucleic Acids Res., 2023
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4Q5S
 | | Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ... | | Authors: | Murakami, K.S. | | Deposit date: | 2014-04-17 | | Release date: | 2014-07-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
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5IPN
 | | SigmaS-transcription initiation complex with 4-nt nascent RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, B, Zuo, Y, Steitz, T.A. | | Deposit date: | 2016-03-09 | | Release date: | 2016-03-30 | | Last modified: | 2016-06-22 | | Method: | X-RAY DIFFRACTION (4.61 Å) | | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4Q4Z
 | | Thermus thermophilus RNA polymerase de novo transcription initiation complex | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ... | | Authors: | Murakami, K.S. | | Deposit date: | 2014-04-15 | | Release date: | 2014-07-30 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
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5IPL
 | | SigmaS-transcription initiation complex with 4-nt nascent RNA | | Descriptor: | DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Liu, B, Zuo, Y, Steitz, T.A. | | Deposit date: | 2016-03-09 | | Release date: | 2016-03-30 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5I2D
 | | Crystal structure of T. thermophilus TTHB099 class II transcription activation complex: TAP-RPo | | Descriptor: | DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Feng, Y, Zhang, Y, Ebright, R.H. | | Deposit date: | 2016-02-08 | | Release date: | 2016-06-22 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (4.405 Å) | | Cite: | Structural basis of transcription activation.
Science, 352, 2016
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5IPM
 | | SigmaS-transcription initiation complex with 4-nt nascent RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, B, Zuo, Y, Steitz, T.A. | | Deposit date: | 2016-03-09 | | Release date: | 2016-03-30 | | Last modified: | 2016-06-22 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7PP4
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7Q4U
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7Q59
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7SZK
 | | Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex | | Descriptor: | (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Shin, Y, Murakami, K.S. | | Deposit date: | 2021-11-28 | | Release date: | 2022-07-13 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
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