6VQU
 
 | | Structure of a bacterial Atm1-family ABC exporter | | Descriptor: | ATM1-type heavy metal exporter | | Authors: | Fan, C, Rees, D.C. | | Deposit date: | 2020-02-05 | | Release date: | 2020-07-29 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | A structural framework for unidirectional transport by a bacterial ABC exporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6UJS
 | | P-glycoprotein mutant-F728A and C952A-with BDE100 | | Descriptor: | 2,4-dibromophenyl 2,4,6-tribromophenyl ether, ATP-dependent translocase ABCB1 | | Authors: | Aller, S.G, Le, C.A. | | Deposit date: | 2019-10-03 | | Release date: | 2020-05-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (4.17 Å) | | Cite: | Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein.
Iucrj, 7, 2020
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6UJN
 | | P-glycoprotein mutant-C952A-with BDE100 | | Descriptor: | 2,4-dibromophenyl 2,4,6-tribromophenyl ether, ATP-dependent translocase ABCB1 | | Authors: | Aller, S.G, Le, C.A. | | Deposit date: | 2019-10-03 | | Release date: | 2020-05-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.98 Å) | | Cite: | Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein.
Iucrj, 7, 2020
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6C3P
 | | Cryo-EM structure of human KATP bound to ATP and ADP in propeller form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | Authors: | Lee, K.P.K, Chen, J, MacKinnon, R. | | Deposit date: | 2018-01-10 | | Release date: | 2018-01-24 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | Molecular structure of human KATP in complex with ATP and ADP.
Elife, 6, 2017
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6BL6
 | | Crystallization of lipid A transporter MsbA from Salmonella typhimurium | | Descriptor: | Lipid A export ATP-binding/permease protein MsbA | | Authors: | Padayatti, P.S, Stanfield, R.L, Zhang, Q, Wilson, I.A, Lee, S.C. | | Deposit date: | 2017-11-09 | | Release date: | 2019-01-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Insights into the Lipid A Transport Pathway in MsbA.
Structure, 27, 2019
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5YWA
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6VQT
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6C3O
 | | Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | Authors: | Lee, K.P.K, Chen, J, MacKinnon, R. | | Deposit date: | 2018-01-10 | | Release date: | 2018-01-31 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Molecular structure of human KATP in complex with ATP and ADP
Elife, 6, 2017
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6D3S
 | | Thermostabilized phosphorylated chicken CFTR | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator | | Authors: | Fay, J.F, Riordan, J.R, Chen, Z.J. | | Deposit date: | 2018-04-16 | | Release date: | 2018-10-17 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.
Biochemistry, 57, 2018
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6BHU
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6BPP
 | | E. coli MsbA in complex with LPS and inhibitor G092 | | Descriptor: | (2E)-3-{6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 3-HYDROXY-TETRADECANOIC ACID, ... | | Authors: | Ho, H, Koth, C.M, Payandeh, J. | | Deposit date: | 2017-11-24 | | Release date: | 2018-05-02 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.92 Å) | | Cite: | Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature, 557, 2018
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6C0V
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6BAA
 | | Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide | | Descriptor: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | Authors: | Martin, G.M, Yoshioka, C, Shyng, S.L. | | Deposit date: | 2017-10-12 | | Release date: | 2017-11-01 | | Last modified: | 2019-12-25 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | Anti-diabetic drug binding site in a mammalian KATPchannel revealed by Cryo-EM.
Elife, 6, 2017
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7BCW
 | | Structure of MsbA in Salipro with ADP vanadate | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent lipid A-core flippase, ... | | Authors: | Traore, D.A.K, Tidow, H. | | Deposit date: | 2020-12-21 | | Release date: | 2022-01-12 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination.
Febs J., 289, 2022
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6O30
 | | Lipid A transporter MsbA from Salmonella typhimurium | | Descriptor: | Lipid A export ATP-binding/permease protein MsbA | | Authors: | Padayatti, P.S, Zhang, Q, Wilson, I.A, Lee, S.C, Stanfield, R.L. | | Deposit date: | 2019-02-25 | | Release date: | 2019-06-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (4.47 Å) | | Cite: | Structural Insights into the Lipid A Transport Pathway in MsbA.
Structure, 27, 2019
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7BG4
 | | Multidrug resistance transporter BmrA mutant E504A bound with ATP, Mg, and Rhodamine 6G solved by Cryo-EM | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA, ... | | Authors: | Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. | | Deposit date: | 2021-01-05 | | Release date: | 2022-01-12 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Sci Adv, 8, 2022
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8PMD
 | | Nucleotide-bound BSEP in nanodiscs | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, MAGNESIUM ION | | Authors: | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | | Deposit date: | 2023-06-28 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
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8QOE
 | | Inward-facing conformation of the ABC transporter BmrA | | Descriptor: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | | Authors: | Di Cesare, M, Kaplan, E, Valimehr, S, Hanssen, E, Orelle, C, Jault, J.M. | | Deposit date: | 2023-09-28 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains.
J.Biol.Chem., 300, 2023
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7EKL
 | | Mitochondrial outer membrane protein | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family B member 6, MAGNESIUM ION | | Authors: | Zhang, S.S. | | Deposit date: | 2021-04-05 | | Release date: | 2021-08-25 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Molecular insights into the human ABCB6 transporter.
Cell Discov, 7, 2021
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6PAM
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6P6J
 | | Structure of YbtPQ importer with substrate Ybt-Fe bound | | Descriptor: | ABC transporter protein, FE (III) ION, inner membrane ABC-transporter, ... | | Authors: | Wang, Z, Hu, W, Zheng, H. | | Deposit date: | 2019-06-04 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter.
Sci Adv, 6, 2020
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7D7N
 | | Cryo-EM structure of human ABCB6 transporter | | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial | | Authors: | Wang, C, Cao, C, Wang, N, Wang, X, Zhang, X.C. | | Deposit date: | 2020-10-05 | | Release date: | 2020-10-21 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5.2 Å) | | Cite: | Cryo-electron microscopy structure of human ABCB6 transporter.
Protein Sci., 29, 2020
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7E1A
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6PAN
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8PM6
 | | Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs | | Descriptor: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL | | Authors: | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | | Deposit date: | 2023-06-28 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
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