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PDB: 120 results

1NNH
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Hypothetical protein from Pyrococcus furiosus Pfu-1801964
Descriptor: SODIUM ION, asparaginyl-tRNA synthetase-related peptide
Authors:Tempel, W, Liu, Z.-J, Schubot, F.D, Shah, A, Arendall III, W.B, Rose, J.P, Richardson, D.C, Richardson, J.S, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2003-01-13
Release date:2004-02-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Hypothetical protein from Pyrococcus furiosus Pfu-1801964
To be published
3G1Z
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BU of 3g1z by Molmil
Structure of IDP01693/yjeA, a potential t-RNA synthetase from Salmonella typhimurium
Descriptor: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Singer, A.U, Evdokimova, E, Kudritska, M, Cuff, M.E, Edwards, A.M, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2009-01-30
Release date:2009-03-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica.
Mol.Cell, 39, 2010
3REX
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BU of 3rex by Molmil
Crystal structure of the archaeal asparagine synthetase A complexed with Adenosine monophosphate
Descriptor: ADENOSINE MONOPHOSPHATE, AsnS-like asparaginyl-tRNA synthetase related protein, MAGNESIUM ION
Authors:Blaise, M, Frechin, M, Charron, C, Roy, H, Sauter, C, Lorber, B, Olieric, V, Kern, D.
Deposit date:2011-04-05
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases.
J.Mol.Biol., 412, 2011
3RL6
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Crystal structure of the archaeal asparagine synthetase A complexed with L-Asparagine and Adenosine monophosphate
Descriptor: ADENOSINE MONOPHOSPHATE, ASPARAGINE, Archaeal asparagine synthetase A, ...
Authors:Blaise, M, Frechin, M, Charron, C, Roy, H, Sauter, C, Lorber, B, Olieric, V, Kern, D.
Deposit date:2011-04-19
Release date:2011-08-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases.
J.Mol.Biol., 412, 2011
3REU
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BU of 3reu by Molmil
Crystal structure of the archaeal asparagine synthetase A complexed with L-Aspartic acid and Adenosine triphosphate
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ASPARTIC ACID, AsnS-like asparaginyl-tRNA synthetase related protein, ...
Authors:Blaise, M, Frechin, M, Charron, C, Roy, H, Sauter, C, Lorber, B, Olieric, V, Kern, D.
Deposit date:2011-04-05
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases.
J.Mol.Biol., 412, 2011
3A5Y
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BU of 3a5y by Molmil
Crystal structure of GenX from Escherichia coli in complex with lysyladenylate analog
Descriptor: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Putative lysyl-tRNA synthetase
Authors:Sumida, T, Yanagisawa, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2009-08-17
Release date:2010-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P.
Nat.Struct.Mol.Biol., 17, 2010
3P8T
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BU of 3p8t by Molmil
Crystal structure of the archaeal asparagine synthetase A
Descriptor: AsnS-like asparaginyl-tRNA synthetase related protein
Authors:Blaise, M, Kern, D.
Deposit date:2010-10-15
Release date:2011-08-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases.
J.Mol.Biol., 412, 2011
3P8V
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BU of 3p8v by Molmil
Crystal structure of the archaeal asparagine synthetase A complexed with L-Aspartic acid
Descriptor: ASPARTIC ACID, AsnS-like asparaginyl-tRNA synthetase related protein
Authors:Blaise, M, Kern, D.
Deposit date:2010-10-15
Release date:2011-08-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases.
J.Mol.Biol., 412, 2011
3P8Y
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BU of 3p8y by Molmil
Crystal structure of the archaeal asparagine synthetase A complexed with L-Asparagine
Descriptor: ASPARAGINE, AsnS-like asparaginyl-tRNA synthetase related protein
Authors:Blaise, M, Kern, D.
Deposit date:2010-10-15
Release date:2011-08-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases.
J.Mol.Biol., 412, 2011
1X54
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Crystal structure of asparaginyl-tRNA synthetase from Pyrococcus horikoshii complexed with asparaginyl-adenylate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, Asparaginyl-tRNA synthetase, ...
Authors:Iwasaki, W, Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-15
Release date:2006-05-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Basis of the Water-assisted Asparagine Recognition by Asparaginyl-tRNA Synthetase.
J.Mol.Biol., 360, 2006
4PG3
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BU of 4pg3 by Molmil
Crystal structure of KRS complexed with inhibitor
Descriptor: LYSINE, Lysine--tRNA ligase, cladosporin
Authors:Sharma, A, Yogavel, M, Khan, S, Sharma, A, Belrhali, H.
Deposit date:2014-05-01
Release date:2014-07-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin.
J. Struct. Funct. Genomics, 15, 2014
6WBD
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BU of 6wbd by Molmil
Crystal Structure of Lysyl-tRNA synthetase from Stenotrophomonas maltophilia with bound L-lysine
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, LYSINE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-03-26
Release date:2020-04-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Lysyl-tRNA synthetase from Stenotrophomonas maltophilia with bound L-lysine
to be published
7F6W
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BU of 7f6w by Molmil
Crystal structure of Saccharomyces cerevisiae lysyl-tRNA Synthetase
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine--tRNA ligase
Authors:Wu, S, Li, P, Hei, Z, Zheng, L, Wang, J, Fang, P.
Deposit date:2021-06-26
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.607 Å)
Cite:Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex.
Cell.Mol.Life Sci., 79, 2022
4WJ3
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BU of 4wj3 by Molmil
Crystal structure of the asparagine transamidosome from Pseudomonas aeruginosa
Descriptor: 76mer-tRNA, Aspartate--tRNA(Asp/Asn) ligase, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, ...
Authors:Suzuki, T, Nakamura, A, Kato, K, Tanaka, I, Yao, M.
Deposit date:2014-09-29
Release date:2014-12-31
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (3.705 Å)
Cite:Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis
Proc.Natl.Acad.Sci.USA, 112, 2015
6WOM
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BU of 6wom by Molmil
Crystal structure of Aspartyl-tRNA ligase from Elizabethkingia sp.
Descriptor: Aspartate--tRNA ligase, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-04-24
Release date:2020-05-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of Aspartyl-tRNA ligase from Elizabethkingia sp.
TO BE PUBLISHED
6SJC
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BU of 6sjc by Molmil
Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)adenosine
Descriptor: 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, Aspartate--tRNA(Asp) ligase
Authors:De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2019-08-13
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
8H53
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BU of 8h53 by Molmil
Human asparaginyl-tRNA synthetase in complex with asparagine-AMP
Descriptor: 4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, Asparagine--tRNA ligase, cytoplasmic, ...
Authors:Park, J.S, Han, B.W.
Deposit date:2022-10-12
Release date:2023-10-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun, 15, 2024
4AH6
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BU of 4ah6 by Molmil
Human mitochondrial aspartyl-tRNA synthetase
Descriptor: ASPARTATE--TRNA LIGASE, MITOCHONDRIAL
Authors:Neuenfeldt, A, Sissler, M, Lorber, B, Florentz, C, Sauter, C.
Deposit date:2012-02-03
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Thermodynamic Properties Distinguish Human Mitochondrial Aspartyl-tRNA Synthetase from Bacterial Homolog with Same 3D Architecture
Nucleic Acids Res., 41, 2013
4RMF
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BU of 4rmf by Molmil
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target
Descriptor: 2,2-bis(hydroxymethyl)propane-1,3-diol, Aspartate--tRNA(Asp/Asn) ligase, FORMIC ACID
Authors:Cox, J.A.G, Gurcha, S.S, Veeraraghavan, U, Besra, G.S, Futterer, K.
Deposit date:2014-10-21
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target.
Plos One, 9, 2014
4O2D
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BU of 4o2d by Molmil
Crystal structure of aspartyl-tRNA synthetase from Mycobacterium smegmatis with bound aspartic acid
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ASPARTIC ACID, Aspartate--tRNA ligase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-12-17
Release date:2014-01-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
7AP4
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BU of 7ap4 by Molmil
Thermus thermophilus Aspartyl-tRNA Synthetase in Complex with Compound AspS7HMDDA
Descriptor: (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid, Aspartate--tRNA(Asp) ligase
Authors:De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-10-15
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
7ZOG
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BU of 7zog by Molmil
Crystal structure of Cryptosporidium parvum -Plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor
Descriptor: 8-[[4-[2-[2-[2-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]sulfonylamino]-~{N}-(cyclohexylmethyl)-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide, GLYCEROL, LYSINE, ...
Authors:Dawson, A, Wyllie, S.
Deposit date:2022-04-25
Release date:2022-09-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
Acs Infect Dis., 8, 2022
4DPG
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BU of 4dpg by Molmil
Crystal Structure of Human LysRS: P38/AIMP2 Complex I
Descriptor: ALANINE, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Fang, P, Wang, J, Bennett, S.P, Guo, M.
Deposit date:2012-02-13
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.
Mol.Cell, 49, 2013
7BT5
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BU of 7bt5 by Molmil
Crystal structure of plasmodium LysRS complexing with an antitumor compound
Descriptor: LYSINE, Lysine--tRNA ligase, N4-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N2-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
Authors:Zhou, J, Wang, J, Fang, P.
Deposit date:2020-03-31
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor.
Nucleic Acids Res., 48, 2020
5ELO
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BU of 5elo by Molmil
Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and cladosporin
Descriptor: 1,2-ETHANEDIOL, LYSINE, Lysine--tRNA ligase, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-11-04
Release date:2016-11-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 2019

225399

數據於2024-09-25公開中

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