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PDB: 311 results

1ZP2
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BU of 1zp2 by Molmil
Structure of the Mediator subunit cyclin C
Descriptor: RNA polymerase II holoenzyme cyclin-like subunit
Authors:Hoeppner, S, Baumli, S, Cramer, P.
Deposit date:2005-05-16
Release date:2005-07-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Mediator Subunit Cyclin C and its Implications for CDK8 Function.
J.Mol.Biol., 350, 2005
6Q6G
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BU of 6q6g by Molmil
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
Descriptor: Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Zhang, S, Barford, D.
Deposit date:2018-12-11
Release date:2019-09-11
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.
Nat Commun, 10, 2019
2PK2
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BU of 2pk2 by Molmil
Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat
Descriptor: Cyclin-T1, Protein Tat
Authors:Anand, K, Schulte, A, Fujinaga, K, Scheffzek, K, Geyer, M.
Deposit date:2007-04-17
Release date:2007-07-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat.
J.Mol.Biol., 370, 2007
1BU2
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BU of 1bu2 by Molmil
X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI
Descriptor: CYCLIN HOMOLOG
Authors:Schulze-Gahmen, U, Jung, J.U, Kim, S.-H.
Deposit date:1998-09-10
Release date:1999-06-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Structure Fold.Des., 7, 1999
2B9R
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BU of 2b9r by Molmil
Crystal Structure of Human Cyclin B1
Descriptor: Human cyclin B1
Authors:Basavappa, R, Petri, E.
Deposit date:2005-10-12
Release date:2006-10-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Human Cyclin B.
Cell Cycle, 6, 2007
1VIN
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BU of 1vin by Molmil
BOVINE CYCLIN A3
Descriptor: CYCLIN A
Authors:Noble, M.E.M, Endicott, J.A.E, Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
1JKW
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BU of 1jkw by Molmil
STRUCTURE OF CYCLIN MCS2
Descriptor: CYCLIN H
Authors:Andersen, G, Poterszman, A, Moras, D, Thierry, J.C.
Deposit date:1996-10-11
Release date:1997-01-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of human cyclin H.
FEBS Lett., 397, 1996
1KXU
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BU of 1kxu by Molmil
CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Descriptor: CYCLIN H
Authors:Kim, K.K, Chamberin, H.M, Morgan, D.O, Kim, S.-H.
Deposit date:1996-08-08
Release date:1997-01-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.
Nat.Struct.Biol., 3, 1996
2IVX
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BU of 2ivx by Molmil
Crystal structure of human cyclin T2 at 1.8 A resolution
Descriptor: 1,2-ETHANEDIOL, CYCLIN-T2
Authors:Debreczeni, J.E, Bullock, A.N, Fedorov, O, Savitsky, P, Berridge, G, Das, S, Pike, A.C.W, Turnbull, A, Ugochukwu, E, Papagrigoriou, E, Gorrec, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, von Delft, F, Knapp, S.
Deposit date:2006-06-21
Release date:2006-07-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
EMBO J., 27, 2008
7LUO
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BU of 7luo by Molmil
N-terminus of Skp2 bound to Cyclin A
Descriptor: S-phase kinase-associated protein 2,Cyclin-A2, Skp2 Motif 1 uncharacterized fragment 1, Skp2 Motif 1 uncharacterized fragment 2
Authors:Kelso, S, Ceccarelli, D.F, Sicheri, F.
Deposit date:2021-02-22
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Bipartite binding of the N terminus of Skp2 to cyclin A.
Structure, 29, 2021
2I53
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BU of 2i53 by Molmil
Crystal structure of Cyclin K
Descriptor: ACETATE ION, Cyclin K
Authors:Baek, K, Brown, R.S, Birrane, G, Ladias, J.A.A.
Deposit date:2006-08-23
Release date:2007-01-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J.Mol.Biol., 366, 2007
6Q6H
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BU of 6q6h by Molmil
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
Descriptor: Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 13, ...
Authors:Zhang, S, Barford, D.
Deposit date:2018-12-11
Release date:2019-09-11
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.
Nat Commun, 10, 2019
2W2H
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BU of 2w2h by Molmil
Structural basis of transcription activation by the Cyclin T1-Tat-TAR RNA complex from EIAV
Descriptor: 5'-R(*GP*CP*UP*CP*AP*GP*AP*UP*CP*UP *GP*CP*GP*GP*UP*CP*UP*GP*AP*GP*C)-3', CYCLIN-T1, MANGANESE (II) ION, ...
Authors:Anand, K, Geyer, M.
Deposit date:2008-10-30
Release date:2008-12-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural Insights Into the Cyclin T1-Tat-Tar RNA Transcription Activation Complex from Eiav.
Nat.Struct.Mol.Biol., 15, 2008
7SJ3
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BU of 7sj3 by Molmil
Structure of CDK4-Cyclin D3 bound to abemaciclib
Descriptor: Cyclin-dependent kinase 4, G1/S-specific cyclin-D3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine
Authors:Hilgers, M.T, Pelletier, L.A.
Deposit date:2021-10-15
Release date:2022-11-02
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of CDK4-Cyclin D3 bound to abemaciclib
To Be Published
7NWK
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BU of 7nwk by Molmil
Crystal structure of CDK9-Cyclin T1 bound by compound 6
Descriptor: Cyclin-T1, Cyclin-dependent kinase 9, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide
Authors:Collie, G.W, Ferguson, A.D.
Deposit date:2021-03-16
Release date:2021-10-27
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J.Med.Chem., 64, 2021
6W9E
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BU of 6w9e by Molmil
Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295
Descriptor: (4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, Cyclin-T1, ...
Authors:Zhang, P, Wu, J.
Deposit date:2020-03-22
Release date:2021-09-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships
To Be Published
4OGR
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BU of 4ogr by Molmil
crystal structure of P-TEFb complex with AFF4 and Tat
Descriptor: ADENOSINE, AF4/FMR2 family member 4, Cyclin-T1, ...
Authors:Schulze-Gahmen, U, Alber, T.
Deposit date:2014-01-16
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.
Elife, 3, 2014
4FX3
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BU of 4fx3 by Molmil
Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
Descriptor: (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Cyclin-A2, ...
Authors:Kang, Y.N, Stuckey, J.A.
Deposit date:2012-07-02
Release date:2013-05-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
To be Published
6TPA
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BU of 6tpa by Molmil
CDK8/CyclinC in complex with drug ETP-50775
Descriptor: (2~{R})-butane-1,2-diol, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea, Cyclin-C, ...
Authors:Munoz, I.G, Pastor, J, Martinez, S.
Deposit date:2019-12-12
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors.
Eur.J.Med.Chem., 201, 2020
7QHL
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BU of 7qhl by Molmil
Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24
Descriptor: 1,2-ETHANEDIOL, 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine, Cyclin-A2, ...
Authors:Djukic, S, Skerlova, J, Rezacova, P.
Deposit date:2021-12-13
Release date:2022-07-06
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
J.Med.Chem., 65, 2022
5L1Z
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BU of 5l1z by Molmil
TAR complex with HIV-1 Tat-AFF4-P-TEFb
Descriptor: AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ...
Authors:Schulze-Gahmen, U, Hurley, J.
Deposit date:2016-07-29
Release date:2016-10-26
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (5.9 Å)
Cite:Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.
Elife, 5, 2016
9FMR
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BU of 9fmr by Molmil
Structure of DDB1/Cdk12/Cyclin K with molecular glue SR-4835
Descriptor: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ...
Authors:Anand, K, Schmitz, M, Geyer, M.
Deposit date:2024-06-07
Release date:2024-10-16
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of DDB1/Cdk12/Cyclin K with molecular glue SR-4835
To Be Published
4UN0
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BU of 4un0 by Molmil
Crystal structure of the human CDK12-cyclinK complex
Descriptor: CYCLIN-DEPENDENT KINASE 12, CYCLIN-K
Authors:Dixon Clarke, S.E, Elkins, J.M, Pike, A.C.W, Chaikuad, A, Goubin, S, Krojer, T, Sorrell, F.J, Nowak, R, Williams, E, Kopec, J, Mahajan, R.P, Burgess-Brown, N, Carpenter, E.P, Knapp, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.
Deposit date:2014-05-22
Release date:2014-06-04
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding.
Sci.Rep., 5, 2015
3LQ5
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BU of 3lq5 by Molmil
Structure of CDK9/CyclinT in complex with S-CR8
Descriptor: (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1
Authors:Hole, A.J, Endicott, J.A, Baumli, S.
Deposit date:2010-02-08
Release date:2011-01-19
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Genes Cancer, 1, 2010
7XQK
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BU of 7xqk by Molmil
The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, G1/S-specific cyclin-E1, GLYCEROL, ...
Authors:Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y.
Deposit date:2022-05-07
Release date:2023-05-17
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus.
To Be Published

227344

數據於2024-11-13公開中

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