1MHE
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![BU of 1mhe by Molmil](/molmil-images/mine/1mhe) | THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E | Descriptor: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN HLA-E, PEPTIDE (VMAPRTVLL), ... | Authors: | O'Callaghan, C.A, Tormo, J, Willcox, B.E, Braud, V.B, Jakobsen, B.K, Stuart, D.I, Mcmichael, A.J, Bell, J.I, Jones, E.Y. | Deposit date: | 1998-08-24 | Release date: | 1999-03-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E. Mol.Cell, 1, 1998
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4PJB
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![BU of 4pjb by Molmil](/molmil-images/mine/4pjb) | Structure of human MR1-5-OP-RU in complex with human MAIT B-F3-C1 TCR | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2014-05-12 | Release date: | 2014-07-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells. J.Exp.Med., 211, 2014
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6VMC
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![BU of 6vmc by Molmil](/molmil-images/mine/6vmc) | |
5BXF
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![BU of 5bxf by Molmil](/molmil-images/mine/5bxf) | Apo FcRn Structure at pH 4.5 | Descriptor: | Beta-2-microglobulin, IgG receptor FcRn large subunit p51 | Authors: | Nam, H.-J, Taha, M. | Deposit date: | 2015-06-08 | Release date: | 2015-11-11 | Method: | X-RAY DIFFRACTION (2.851 Å) | Cite: | Human Fc-Receptor Neonatal at low pH gives insights into different states of FcRn To Be Published
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8HN4
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![BU of 8hn4 by Molmil](/molmil-images/mine/8hn4) | |
8U9G
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![BU of 8u9g by Molmil](/molmil-images/mine/8u9g) | Human Class I MHC HLA-A2 bound to sorting nexin 24 (127-135) neoantigen KLSHQLVLL | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Arbuiso, A, Weiss, L.I, Brambley, C.A, Ma, J, Keller, G.L.J, Ayres, C.M, Baker, B.M. | Deposit date: | 2023-09-19 | Release date: | 2024-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Accurate modeling of peptide-MHC structures with AlphaFold. Structure, 32, 2024
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4LHU
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![BU of 4lhu by Molmil](/molmil-images/mine/4lhu) | Crystal Structure of 9C2 TCR bound to CD1d | Descriptor: | (15Z)-N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxyoctadecan-2-yl]tetracos-15-enamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Uldrich, A.P, Le Nours, J, Pellicci, D.G, Gras, S, Rossjohn, J, Godfrey, D.I. | Deposit date: | 2013-07-01 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | CD1d-lipid antigen recognition by the gamma delta TCR. Nat.Immunol., 14, 2013
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5V5M
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![BU of 5v5m by Molmil](/molmil-images/mine/5v5m) | |
4EUP
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![BU of 4eup by Molmil](/molmil-images/mine/4eup) | |
2J8U
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![BU of 2j8u by Molmil](/molmil-images/mine/2j8u) | Large CDR3a loop alteration as a function of MHC mutation. | Descriptor: | AHIII TCR ALPHA CHAIN, AHIII TCR BETA CHAIN, Beta-2-microglobulin, ... | Authors: | Miller, P.J, Benhar, Y.P, Biddison, W, Collins, E.J. | Deposit date: | 2006-10-27 | Release date: | 2007-10-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Single MHC mutation eliminates enthalpy associated with T cell receptor binding. J. Mol. Biol., 373, 2007
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7LGD
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![BU of 7lgd by Molmil](/molmil-images/mine/7lgd) | HLA-B*07:02 in complex with SARS-CoV-2 nucleocapsid peptide N105-113 | Descriptor: | Beta-2-microglobulin, CHLORIDE ION, HLA class I histocompatibility antigen, ... | Authors: | Gras, S, Szeto, C, Chatzileontiadou, D.S.M. | Deposit date: | 2021-01-20 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | CD8 + T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses. Immunity, 54, 2021
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5INC
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![BU of 5inc by Molmil](/molmil-images/mine/5inc) | Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection | Descriptor: | Beta-2-microglobulin, GLN-ALA-THR-GLN-GLU-VAL-LYS-ASN-TRP, HLA class I histocompatibility antigen, ... | Authors: | Li, X, Wang, J.-H. | Deposit date: | 2016-03-07 | Release date: | 2016-10-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.881 Å) | Cite: | Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection. Protein Cell, 7, 2016
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5NMF
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![BU of 5nmf by Molmil](/molmil-images/mine/5nmf) | 868 TCR in complex with HLA A02 presenting SLYNTIATL | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K. | Deposit date: | 2017-04-05 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope. Front Immunol, 8, 2017
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4QRP
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![BU of 4qrp by Molmil](/molmil-images/mine/4qrp) | Crystal Structure of HLA B*0801 in complex with HSKKKCDEL and DD31 TCR | Descriptor: | Beta-2-microglobulin, DD31 TCR alpha chain, DD31 TCR beta chain, ... | Authors: | Gras, S, Berry, R, Lucet, I.S, Rossjohn, J. | Deposit date: | 2014-07-02 | Release date: | 2014-11-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant. J.Immunol., 193, 2014
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3S6C
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![BU of 3s6c by Molmil](/molmil-images/mine/3s6c) | Structure of human CD1e | Descriptor: | Beta-2-microglobulin, T-cell surface glycoprotein CD1e, membrane-associated, ... | Authors: | Garcia-Alles, L.F, Maveyraud, L, Tranier, S, Mourey, L. | Deposit date: | 2011-05-25 | Release date: | 2011-07-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes. Proc.Natl.Acad.Sci.USA, 108, 2011
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1B0R
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![BU of 1b0r by Molmil](/molmil-images/mine/1b0r) | CRYSTAL STRUCTURE OF HLA-A*0201 COMPLEXED WITH A PEPTIDE WITH THE CARBOXYL-TERMINAL GROUP SUBSTITUTED BY A METHYL GROUP | Descriptor: | PROTEIN (HLA-A*0201), PROTEIN (INFLUENZA MATRIX PEPTIDE) | Authors: | Bouvier, M, Guo, H, Smith, K.J, Wiley, D.C. | Deposit date: | 1998-11-12 | Release date: | 1999-11-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of HLA-A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal group substituted by a methyl group. Proteins, 33, 1998
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8EB2
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![BU of 8eb2 by Molmil](/molmil-images/mine/8eb2) | |
7R80
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![BU of 7r80 by Molmil](/molmil-images/mine/7r80) | Crystal structure of C3 TCR complex with QW9-bound HLA-B*5301 | Descriptor: | Alpha chain of C3 TCR, Beta Chain of C3 TCR, Beta-2-microglobulin, ... | Authors: | Li, X.L, Tan, K.M, Walker, B.D, Wang, J.H. | Deposit date: | 2021-06-25 | Release date: | 2022-06-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide. Nat Commun, 14, 2023
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7JYW
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![BU of 7jyw by Molmil](/molmil-images/mine/7jyw) | Crystal Structure of HLA A*2402 in complex with TYQWIIRNW, an 9-mer influenza epitope | Descriptor: | Beta-2-microglobulin, CALCIUM ION, MHC class I antigen, ... | Authors: | Gras, S, Nguyen, A.T, Szeto, C, Rossjohn, J. | Deposit date: | 2020-09-01 | Release date: | 2021-04-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | CD8 + T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph. Nat Commun, 12, 2021
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7NDU
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![BU of 7ndu by Molmil](/molmil-images/mine/7ndu) | Gag:02 TCR in complex with HLA-E featuring a non-natural amino acid | Descriptor: | Beta-2-microglobulin, Gag6V(276-284 H4C), HLA class I histocompatibility antigen, ... | Authors: | Pengelly, R.J, Robinson, R.A. | Deposit date: | 2021-02-02 | Release date: | 2022-01-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition. Eur.J.Immunol., 52, 2022
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6FGB
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![BU of 6fgb by Molmil](/molmil-images/mine/6fgb) | Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab | Descriptor: | 1519.g57- Heavy chain, 1519.g57- Light chain, Beta-2-microglobulin, ... | Authors: | Sarkar, K, Ceska, T, Meier, C. | Deposit date: | 2018-01-10 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration. MAbs, 10, 2018
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3HAE
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![BU of 3hae by Molmil](/molmil-images/mine/3hae) | Rational development of high-affinity T-cell receptor-like antibodies | Descriptor: | Antibody heavy chain, Antibody light chain, Beta-2-microglobulin, ... | Authors: | Stewart-Jones, G, Wadle, A, Hombach, A, Shenderov, E, Held, G, Fischer, E. | Deposit date: | 2009-05-01 | Release date: | 2009-05-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Rational development of high-affinity T-cell receptor-like antibodies Proc.Natl.Acad.Sci.USA, 106, 2009
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6XQP
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![BU of 6xqp by Molmil](/molmil-images/mine/6xqp) | Structure of human D462-E4 TCR in complex with human MR1-5-OP-RU | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, BROMIDE ION, Beta-2-microglobulin, ... | Authors: | Awad, W, Rossjohn, J. | Deposit date: | 2020-07-10 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Atypical TRAV1-2 - T cell receptor recognition of the antigen-presenting molecule MR1. J.Biol.Chem., 295, 2020
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1PY4
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![BU of 1py4 by Molmil](/molmil-images/mine/1py4) | Beta2 microglobulin mutant H31Y displays hints for amyloid formations | Descriptor: | Beta-2-microglobulin precursor | Authors: | Rosano, C, Zuccotti, S, Mangione, P, Giorgetti, S, Bellotti, V, Pettirossi, F, Corazza, A, Viglino, P, Esposito, G, Bolognesi, M. | Deposit date: | 2003-07-08 | Release date: | 2004-05-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation J.Mol.Biol., 335, 2004
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6VM9
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![BU of 6vm9 by Molmil](/molmil-images/mine/6vm9) | |