8EB2

Structure of HLA-A*02:01 in complex with NY-ESO-1 peptide and PA2.1 Fab

Summary for 8EB2

• Entry DOI: 10.2210/pdb8eb2/pdb
• Descriptor: HLA-A*02:01 alpha chain, Beta-2-microglobulin, NY-ESO-1 peptide, ... (5 entities in total)
• Functional Keywords: complex, fab, antibody, mhc class i, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 15
• Total formula weight: 277758.34

Authors

Jette, C.A.,West, A.P. (deposition date: 2022-08-30, release date: 2022-11-30, Last modification date: 2024-01-31)

• Primary citation: Mock, J.Y.,Winters, A.,Riley, T.P.,Bruno, R.,Naradikian, M.S.,Sharma, S.,Jette, C.A.,Elshimali, R.,Gahrs, C.,Toledo-Warshaviak, D.,West Jr., A.P.,Kamb, A.,Hamburger, A.E.; HLA-A∗02-gated safety switch for cancer therapy has exquisite specificity for its allelic target antigen.; Mol Ther Oncolytics, 27:157-166, 2022; PubMed: 36381658; DOI: 10.1016/j.omto.2022.09.010

Experimental method

X-RAY DIFFRACTION (2.9 Å)