4V6A
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![BU of 4v6a by Molmil](/molmil-images/mine/4v6a) | Structure of EF-P bound to the 70S ribosome. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Stanley, R.E, Blaha, G. | Deposit date: | 2009-06-15 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science, 325, 2009
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4V7Z
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![BU of 4v7z by Molmil](/molmil-images/mine/4v7z) | Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin. | Descriptor: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | Deposit date: | 2010-08-18 | Release date: | 2014-07-09 | Last modified: | 2021-01-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc.Natl.Acad.Sci.USA, 107, 2010
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4V5L
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![BU of 4v5l by Molmil](/molmil-images/mine/4v5l) | The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Voorhees, R.M, Schmeing, T.M, Ramakrishnan, V. | Deposit date: | 2010-09-02 | Release date: | 2014-07-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Mechanism for Activation of GTP Hydrolysis on the Ribosome. Science, 330, 2010
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4YZV
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![BU of 4yzv by Molmil](/molmil-images/mine/4yzv) | Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Schureck, M.A, Dunkle, J.A, Maehigashi, T, Dunham, C.M. | Deposit date: | 2015-03-25 | Release date: | 2015-10-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Defining the mRNA recognition signature of a bacterial toxin protein. Proc.Natl.Acad.Sci.USA, 112, 2015
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6QNR
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![BU of 6qnr by Molmil](/molmil-images/mine/6qnr) | 70S ribosome elongation complex (EC) with experimentally assigned potassium ions | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Khusainov, I, Yusupov, M, Yusupova, G. | Deposit date: | 2019-02-11 | Release date: | 2019-06-19 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction. Nat Commun, 10, 2019
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6ORD
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![BU of 6ord by Molmil](/molmil-images/mine/6ord) | Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Nguyen, H.A, Sunita, S, Dunham, C.M. | Deposit date: | 2019-04-30 | Release date: | 2020-06-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proc.Natl.Acad.Sci.USA, 117, 2020
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7AZS
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![BU of 7azs by Molmil](/molmil-images/mine/7azs) | 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569 | Descriptor: | (2R,3S,4R,5R,7S,9S,10S,11R,12S,13R)-12-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2-((S)-1-(((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)-10-(((2S,3R,6R,E)-3-hydroxy-4-(methoxyimino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-7-(((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)carbamoyl)oxy)-6,14-dioxooxacyclotetradecan-4-yl 3-methylbutanoate, 16S rRNA, 23S rRNA, ... | Authors: | Jenner, L.B, Yusupov, M, Yusupova, G, Rak, A. | Deposit date: | 2020-11-17 | Release date: | 2022-06-08 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186, 2023
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6OPE
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![BU of 6ope by Molmil](/molmil-images/mine/6ope) | Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Nguyen, H.A, Sunita, S, Dunham, C.M. | Deposit date: | 2019-04-24 | Release date: | 2020-06-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proc.Natl.Acad.Sci.USA, 117, 2020
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4ZER
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![BU of 4zer by Molmil](/molmil-images/mine/4zer) | Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16s ribosomal RNA, 23s ribosomal RNA, ... | Authors: | Seefeldt, A.C, Nguyen, F, Antunes, S, Perebaskine, N, Graf, M, Arenz, S, Inampudi, K.K, Douat, C, Guichard, G, Wilson, D.N, Innis, C.A. | Deposit date: | 2015-04-20 | Release date: | 2015-05-20 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat.Struct.Mol.Biol., 22, 2015
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5DOX
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![BU of 5dox by Molmil](/molmil-images/mine/5dox) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | Deposit date: | 2015-09-11 | Release date: | 2015-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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4V5Q
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![BU of 4v5q by Molmil](/molmil-images/mine/4v5q) | The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | Deposit date: | 2010-12-07 | Release date: | 2014-07-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding. Nat.Struct.Mol.Biol., 18, 2011
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6OTR
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![BU of 6otr by Molmil](/molmil-images/mine/6otr) | Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU) | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Pavelich, I.P, Hoffer, E.D, Maehigashi, T, Dunham, C.M. | Deposit date: | 2019-05-03 | Release date: | 2019-08-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability. Nucleic Acids Res., 47, 2019
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6CZR
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![BU of 6czr by Molmil](/molmil-images/mine/6czr) | The structure of amicetin bound to the 70S ribosome | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Eiler, D.R, Steitz, T.A, Looper, R.E, Serrano, C.M, Kannareddy, H.R, Koch, M.R, Barrows, L.R, Testa, C.A, Sebahar, P.R. | Deposit date: | 2018-04-09 | Release date: | 2019-04-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | Unifying the Aminohexopyranose- and Peptidyl-Nucleoside Antibiotics: Implications for Antibiotic Design Angew.Chem.Int.Ed.Engl., 132, 2020
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4LT8
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![BU of 4lt8 by Molmil](/molmil-images/mine/4lt8) | Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Maehigashi, T, Dunkle, J.A, Dunham, C.M. | Deposit date: | 2013-07-23 | Release date: | 2014-08-06 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (3.14000177 Å) | Cite: | Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops. Proc.Natl.Acad.Sci.USA, 111, 2014
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4WQR
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![BU of 4wqr by Molmil](/molmil-images/mine/4wqr) | Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | Deposit date: | 2014-10-22 | Release date: | 2015-06-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural insights into the translational infidelity mechanism. Nat Commun, 6, 2015
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6GSL
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![BU of 6gsl by Molmil](/molmil-images/mine/6gsl) | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Yusupov, M, Yusupova, G. | Deposit date: | 2018-06-14 | Release date: | 2018-07-04 | Last modified: | 2018-09-05 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria. Nucleic Acids Res., 46, 2018
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6BZ6
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![BU of 6bz6 by Molmil](/molmil-images/mine/6bz6) | Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Hoffer, E.D, Maehigashi, T, Fagan, C.E, Dunham, C.M. | Deposit date: | 2017-12-22 | Release date: | 2018-11-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding. Nucleic Acids Res., 47, 2019
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4V8A
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![BU of 4v8a by Molmil](/molmil-images/mine/4v8a) | The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Bulkley, D, Johnson, F.A, Steitz, T.A. | Deposit date: | 2011-12-05 | Release date: | 2014-07-09 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome. J.Mol.Biol., 416, 2012
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5J30
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![BU of 5j30 by Molmil](/molmil-images/mine/5j30) | |
4V95
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![BU of 4v95 by Molmil](/molmil-images/mine/4v95) | Crystal structure of YAEJ bound to the 70S ribosome | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | Authors: | Gagnon, M.G, Seetharaman, S.V, Bulkley, D.P, Steitz, T.A. | Deposit date: | 2012-01-27 | Release date: | 2014-07-09 | Last modified: | 2018-07-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science, 335, 2012
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6FKR
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![BU of 6fkr by Molmil](/molmil-images/mine/6fkr) | Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome | Descriptor: | 16 ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Mardirossian, M, Perebaskine, N, Benincasa, M, Gambato, S, Hofmann, S, Huter, P, Muller, C, Hilpert, K, Innis, C.A, Tossi, A, Wilson, D.N. | Deposit date: | 2018-01-24 | Release date: | 2018-03-28 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome. Cell Chem Biol, 25, 2018
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4V5K
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![BU of 4v5k by Molmil](/molmil-images/mine/4v5k) | Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Ng, C.L, Lang, K, Meenan, N.A.G, Sharma, A, Kelley, A.C, Kleanthous, C, Ramakrishnan, V. | Deposit date: | 2010-05-29 | Release date: | 2014-07-09 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Basis for 16S Ribosomal RNA Cleavage by the Cytotoxic Domain of Colicin E3. Nat.Struct.Mol.Biol., 17, 2010
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6NUO
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![BU of 6nuo by Molmil](/molmil-images/mine/6nuo) | Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate) | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Hoffer, E.D, Subaramanian, S, Hong, S, Maehigashi, T, Dunham, C.M. | Deposit date: | 2019-02-01 | Release date: | 2020-10-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing. Elife, 9, 2020
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5UQ8
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![BU of 5uq8 by Molmil](/molmil-images/mine/5uq8) | 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA ("out" conformation) | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhang, Y, Hong, S, Skiniotis, G, Dunham, C.M. | Deposit date: | 2017-02-07 | Release date: | 2018-03-07 | Last modified: | 2018-03-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel. Structure, 26, 2018
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6C5L
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![BU of 6c5l by Molmil](/molmil-images/mine/6c5l) | |