4ZER

Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome

This is a non-PDB format compatible entry.

Summary for 4ZER

• Entry DOI: 10.2210/pdb4zer/pdb
• Descriptor: 23s ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (63 entities in total)
• Functional Keywords: bacterial ribosome, proline-rich antimicrobial peptide, antibiotics, protein biosynthesis, ribosome
• Biological source: Escherichia coli K-12; More
• Total number of polymer chains: 110
• Total formula weight: 4412861.84

Authors

Seefeldt, A.C.,Nguyen, F.,Antunes, S.,Perebaskine, N.,Graf, M.,Arenz, S.,Inampudi, K.K.,Douat, C.,Guichard, G.,Wilson, D.N.,Innis, C.A. (deposition date: 2015-04-20, release date: 2015-05-20, Last modification date: 2024-01-10)

• Primary citation: Seefeldt, A.C.,Nguyen, F.,Antunes, S.,Perebaskine, N.,Graf, M.,Arenz, S.,Inampudi, K.K.,Douat, C.,Guichard, G.,Wilson, D.N.,Innis, C.A.; The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.; Nat.Struct.Mol.Biol., 22:470-475, 2015; PubMed: 25984971; DOI: 10.1038/nsmb.3034

Experimental method

X-RAY DIFFRACTION (3.1 Å)