3IX3
| LasR-OC12 HSL complex | Descriptor: | N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-03 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | LasR-OC12 HSL complex TO BE PUBLISHED
|
|
6MWL
| LasR LBD:mBTL complex | Descriptor: | 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-29 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
|
|
6D6L
| |
6D6P
| |
6D6O
| |
6MWZ
| LasR LBD T75V/Y93F/A127W:BB0126 | Descriptor: | 4-[3-(methylsulfonyl)phenoxy]-N-[(1S,3S,5S)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, ALA-HIS-HIS-HIS-HIS-ALA, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.657 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
|
|
6D6B
| |
6D6D
| |
2UV0
| Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer | Descriptor: | N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR | Authors: | Bottomley, M.J, Muraglia, E, Bazzo, R, Carfi, A. | Deposit date: | 2007-03-08 | Release date: | 2007-03-27 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular Insights Into Quorum Sensing in the Human Pathogen Pseudomonas Aeruginosa from the Structure of the Virulence Regulator Lasr Bound to its Autoinducer. J.Biol.Chem., 282, 2007
|
|
3IX4
| LasR-TP1 complex | Descriptor: | 2,4-dibromo-6-({[(2-nitrophenyl)carbonyl]amino}methyl)phenyl 2-chlorobenzoate, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-03 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
|
|
3IX8
| LasR-TP3 complex | Descriptor: | 2,4-dibromo-6-({[(2-chlorophenyl)carbonyl]amino}methyl)phenyl 2-methylbenzoate, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-03 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
|
|
6D6N
| The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 16 | Descriptor: | 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 4-methoxybenzoate, PHENYLALANINE, Transcriptional activator protein LasR | Authors: | Dong, S.H, Nair, S.K. | Deposit date: | 2018-04-21 | Release date: | 2018-08-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chem Biol, 25, 2018
|
|
6D6C
| |
6D6M
| |
6D6A
| |
6MWH
| LasR LBD:BB0020 complex | Descriptor: | 2-(3-bromophenoxy)-N-[(1S,2S,3R,5S)-2-hydroxybicyclo[3.1.0]hexan-3-yl]acetamide, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-29 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
|
|
3JPU
| LasR-TP4 complex | Descriptor: | 4-bromo-2-({[(2-chlorophenyl)carbonyl]amino}methyl)-6-methylphenyl 2,4-dichlorobenzoate, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-04 | Release date: | 2009-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
|
|
4NG2
| |
6MWW
| LasR LBD:BB0126 complex | Descriptor: | 4-[3-(methylsulfonyl)phenoxy]-N-[(1R,3R,5R)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
|
|
6V7X
| Structure of a phage-encoded quorum sensing anti-activator, Aqs1 bound to LasR | Descriptor: | N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, QUORUM SENSING ANTI-ACTIVATOR PROTEIN AQS1, Transcriptional regulator LasR | Authors: | Shah, M, Moraes, T.F, Maxwell, K.L. | Deposit date: | 2019-12-09 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa. Mol.Cell, 81, 2021
|
|
6V7W
| |