8SN4
 
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 2) | | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | Deposit date: | 2023-04-26 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
|
|
8SN8
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 6) | | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | Deposit date: | 2023-04-26 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
|
|
4NQK
 | | Structure of an Ubiquitin complex | | Descriptor: | Probable ATP-dependent RNA helicase DDX58, Ubiquitin | | Authors: | Peisley, A, Wu, B, Hur, S. | | Deposit date: | 2013-11-25 | | Release date: | 2014-03-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.
Nature, 509, 2014
|
|
8Q7R
 | | Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide | | Descriptor: | 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | | Deposit date: | 2023-08-16 | | Release date: | 2024-02-21 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Mol.Cell, 84, 2024
|
|
8PQL
 | | K48-linked ubiquitin chain formation with a cullin-RING E3 ligase and Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2-donor UB-acceptor UB-SIL1 peptide | | Descriptor: | 5-azanylpentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | | Deposit date: | 2023-07-11 | | Release date: | 2024-02-14 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases.
Nat.Struct.Mol.Biol., 31, 2024
|
|
7B5L
 | | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 | | Descriptor: | 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... | | Authors: | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | | Deposit date: | 2020-12-04 | | Release date: | 2021-02-10 | | Last modified: | 2021-03-10 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
|
|
8TXV
 | | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 1) | | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | Deposit date: | 2023-08-24 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
|
|
5OHM
 | | K33-specific affimer bound to K33 diUb | | Descriptor: | K33-specific affimer, POLYETHYLENE GLYCOL (N=34), Polyubiquitin-C | | Authors: | Michel, M.A, Komander, D. | | Deposit date: | 2017-07-17 | | Release date: | 2017-10-04 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.
Mol. Cell, 68, 2017
|
|
6TNF
 | | Structure of monoubiquitinated FANCD2 in complex with FANCI and DNA | | Descriptor: | DNA (33-MER), FANCD2, Fanconi anemia complementation group I, ... | | Authors: | Alcon, P, Shakeel, S, Passmore, L.A. | | Deposit date: | 2019-12-07 | | Release date: | 2020-02-19 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
Nat.Struct.Mol.Biol., 27, 2020
|
|
8SN3
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 1) | | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | Deposit date: | 2023-04-26 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
|
|
4DDI
 | | Crystal structure of human OTUB1/UbcH5b~Ub/Ub | | Descriptor: | Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1 | | Authors: | Juang, Y.C, Sanches, M, Sicheri, F. | | Deposit date: | 2012-01-18 | | Release date: | 2012-02-22 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (3.802 Å) | | Cite: | OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45, 2012
|
|
4ZUX
 | |
5CVO
 | | WDR48:USP46~ubiquitin ternary complex | | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | | Authors: | Harris, S.F, Yin, J. | | Deposit date: | 2015-07-27 | | Release date: | 2015-10-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.885 Å) | | Cite: | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
|
|
6VAF
 | |
5VO0
 | | Structure of a TRAF6-Ubc13~Ub complex | | Descriptor: | POTASSIUM ION, TNF receptor-associated factor 6, Ubiquitin, ... | | Authors: | Middleton, A.J, Day, C.L. | | Deposit date: | 2017-05-01 | | Release date: | 2017-12-06 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.
Nat Commun, 8, 2017
|
|
8SN5
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 3) | | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | Deposit date: | 2023-04-26 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
|
|
8SN9
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with backside ubiquitin (UbcH5c chemically conjugated to histone H2A) (class 1) | | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | Deposit date: | 2023-04-26 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
|
|
7B5M
 | | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-p27~Ub~ARIH1. Transition State 2 | | Descriptor: | Cullin-1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ... | | Authors: | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | | Deposit date: | 2020-12-05 | | Release date: | 2021-02-17 | | Last modified: | 2021-03-10 | | Method: | ELECTRON MICROSCOPY (3.91 Å) | | Cite: | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
|
|
8SNA
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with backside ubiquitin (UbcH5c chemically conjugated to histone H2A) (class 2) | | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | Deposit date: | 2023-04-26 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
|
|
7TV4
 | | Crystal structure of NEMO CoZi in complex with HOIP NZF1 and linear diubiquitin | | Descriptor: | E3 ubiquitin-protein ligase RNF31, NF-kappa-B essential modulator, Polyubiquitin-C, ... | | Authors: | Rahighi, S, Iyer, M, Oveisi, H. | | Deposit date: | 2022-02-03 | | Release date: | 2022-08-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain.
Sci Rep, 12, 2022
|
|
7UD5
 | | Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome | | Descriptor: | 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C. | | Deposit date: | 2022-03-18 | | Release date: | 2022-09-21 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (4.25 Å) | | Cite: | Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
6FTX
 | | Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromatin-remodeling ATPase, ... | | Authors: | Sundaramoorthy, R, Owen-hughes, T, Norman, D.G, Hughes, A. | | Deposit date: | 2018-02-25 | | Release date: | 2018-08-08 | | Last modified: | 2018-10-17 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome.
Elife, 7, 2018
|
|
5GJQ
 | | Structure of the human 26S proteasome bound to USP14-UbAl | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | | Authors: | Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. | | Deposit date: | 2016-07-01 | | Release date: | 2016-08-17 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
|
|
5KGF
 | | Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution | | Descriptor: | DNA (145-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... | | Authors: | Wilson, M.D, Benlekbir, S, Sicheri, F, Rubinstein, J.L, Durocher, D. | | Deposit date: | 2016-06-13 | | Release date: | 2016-07-27 | | Last modified: | 2020-01-15 | | Method: | ELECTRON MICROSCOPY (4.54 Å) | | Cite: | The structural basis of modified nucleosome recognition by 53BP1.
Nature, 536, 2016
|
|
6WJD
 | |
