8GOH
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1JYE
| Structure of a Dimeric Lac Repressor with C-terminal Deletion and K84L Substitution | Descriptor: | GLYCEROL, Lactose Operon Repressor | Authors: | Bell, C.E, Barry, J, Matthews, K.S, Lewis, M. | Deposit date: | 2001-09-12 | Release date: | 2001-10-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator. J.Mol.Biol., 313, 2001
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2P9H
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3EDC
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1EFA
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1TLF
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1LBI
| LAC REPRESSOR | Descriptor: | LAC REPRESSOR | Authors: | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | Deposit date: | 1996-02-17 | Release date: | 1996-07-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science, 271, 1996
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4RZS
| Lac repressor engineered to bind sucralose, unliganded tetramer | Descriptor: | GLYCEROL, Lac repressor | Authors: | Arbing, M.A, Cascio, D, Kosuri, S, Church, G.M. | Deposit date: | 2014-12-24 | Release date: | 2015-12-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Engineering an allosteric transcription factor to respond to new ligands. Nat.Methods, 13, 2016
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1JYF
| Structure of the Dimeric Lac Repressor with an 11-residue C-terminal Deletion. | Descriptor: | GLYCEROL, Lactose Operon Repressor | Authors: | Bell, C.E, Barry, J, Matthews, K.S, Lewis, M. | Deposit date: | 2001-09-12 | Release date: | 2001-10-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator. J.Mol.Biol., 313, 2001
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4RZT
| Lac repressor engineered to bind sucralose, sucralose-bound tetramer | Descriptor: | 4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose, Lac repressor | Authors: | Arbing, M.A, Cascio, D, Sawaya, M.R, Kosuri, S, Church, G.M. | Deposit date: | 2014-12-24 | Release date: | 2015-12-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Engineering an allosteric transcription factor to respond to new ligands. Nat.Methods, 13, 2016
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1LBH
| INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG | Descriptor: | 1-methylethyl 1-thio-beta-D-galactopyranoside, INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG | Authors: | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | Deposit date: | 1996-02-17 | Release date: | 1996-07-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science, 271, 1996
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2PE5
| Crystal Structure of the Lac Repressor bound to ONPG in repressed state | Descriptor: | 2-nitrophenyl beta-D-galactopyranoside, DNA (5'-D(*DAP*DAP*DTP*DTP*DGP*DTP*DGP*DAP*DGP*DCP*DGP*DCP*DTP*DCP*DAP*DCP*DAP*DAP*DTP*DT)-3'), Lactose operon repressor | Authors: | Daber, R, Stayrook, S.E, Rosenberg, A, Lewis, M. | Deposit date: | 2007-04-02 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural analysis of lac repressor bound to allosteric effectors J.Mol.Biol., 370, 2007
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2PAF
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1JWL
| Structure of the Dimeric lac Repressor/Operator O1/ONPF Complex | Descriptor: | 2-nitrophenyl beta-D-fucopyranoside, 5'-D(*AP*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*T)-3', 5'-D(*TP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', ... | Authors: | Bell, C.E, Lewis, M. | Deposit date: | 2001-09-04 | Release date: | 2001-10-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystallographic analysis of Lac repressor bound to natural operator O1. J.Mol.Biol., 312, 2001
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1LBG
| LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY | Descriptor: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), PROTEIN (LACTOSE OPERON REPRESSOR) | Authors: | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | Deposit date: | 1996-01-03 | Release date: | 1996-02-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (4.8 Å) | Cite: | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science, 271, 1996
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1LQC
| LAC REPRESSOR HEADPIECE (RESIDUES 1-56), NMR, 32 STRUCTURES | Descriptor: | LAC REPRESSOR | Authors: | Slijper, M, Bonvin, A.M.J.J, Boelens, R, Kaptein, R. | Deposit date: | 1996-08-13 | Release date: | 1997-02-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Refined structure of lac repressor headpiece (1-56) determined by relaxation matrix calculations from 2D and 3D NOE data: change of tertiary structure upon binding to the lac operator. J.Mol.Biol., 259, 1996
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1LCC
| STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | Descriptor: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ... | Authors: | Chuprina, V.P, Rullmann, J.A.C, Lamerichs, R.M.J.N, Van Boom, J.H, Boelens, R, Kaptein, R. | Deposit date: | 1993-03-25 | Release date: | 1994-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. J.Mol.Biol., 234, 1993
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1LCD
| STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | Descriptor: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ... | Authors: | Chuprina, V.P, Rullmann, J.A.C, Lamerichs, R.M.J.N, Van Boom, J.H, Boelens, R, Kaptein, R. | Deposit date: | 1993-03-25 | Release date: | 1994-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. J.Mol.Biol., 234, 1993
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2BJC
| NMR structure of a protein-DNA complex of an altered specificity mutant of the lac repressor headpiece that mimics the gal repressor | Descriptor: | 5'-D(*GP*AP*AP*TP*TP*GP*TP*AP*AP*GP *CP*GP*CP*TP*TP*AP*CP*AP*AP*TP*TP*C)-3', LACTOSE OPERON REPRESSOR | Authors: | Salinas, R.K, Folkers, G.E, Bonvin, A.M.J.J, Das, D, Boelens, R, Kaptein, R. | Deposit date: | 2005-02-01 | Release date: | 2005-10-18 | Last modified: | 2020-01-15 | Method: | SOLUTION NMR | Cite: | Altered Specificity in DNA Binding by the Lac Repressor: A Mutant Lac Headpiece that Mimics the Gal Repressor Chembiochem, 6, 2005
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1L1M
| SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1 | Descriptor: | 5'-D(*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3', Lactose operon repressor | Authors: | Kalodimos, C.G, Bonvin, A.M.J.J, Salinas, R.K, Wechselberger, R, Boelens, R, Kaptein, R. | Deposit date: | 2002-02-19 | Release date: | 2002-06-26 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain. EMBO J., 21, 2002
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1CJG
| NMR STRUCTURE OF LAC REPRESSOR HP62-DNA COMPLEX | Descriptor: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), PROTEIN (LAC REPRESSOR) | Authors: | Spronk, C.A.E.M, Bonvin, A.M.J.J, Radha, P.K, Melacini, G, Boelens, R, Kaptein, R. | Deposit date: | 1999-04-14 | Release date: | 2000-01-01 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator. Structure Fold.Des., 7, 1999
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1OSL
| Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence | Descriptor: | 5'-D(*CP*GP*AP*TP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*AP*TP*CP*G)-3', Lactose operon repressor | Authors: | Kalodimos, C.G, Bonvin, A.M.J.J, Boelens, R, Kaptein, R. | Deposit date: | 2003-03-20 | Release date: | 2004-05-04 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes. Science, 305, 2004
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2KEJ
| Solution structure of a dimer of LAC repressor DNA-binding domain complexed to its natural operator O2 | Descriptor: | DNA (5'-D(*GP*AP*AP*AP*TP*GP*TP*GP*AP*GP*CP*GP*AP*GP*TP*AP*AP*CP*AP*AP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*TP*TP*GP*TP*TP*AP*CP*TP*CP*GP*CP*TP*CP*AP*CP*AP*TP*TP*TP*C)-3'), Lactose operon repressor | Authors: | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | Deposit date: | 2009-01-30 | Release date: | 2009-05-19 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. J.Mol.Biol., 390, 2009
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2KEI
| Refined Solution Structure of a Dimer of LAC repressor DNA-Binding domain complexed to its natural operator O1 | Descriptor: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), Lactose operon repressor | Authors: | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | Deposit date: | 2009-01-30 | Release date: | 2009-05-19 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. J.Mol.Biol., 390, 2009
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2KEK
| Solution structure of a dimer of LAC repressor DNA-binding domain complexed to its natural operator O3 | Descriptor: | DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*GP*AP*GP*CP*GP*CP*AP*AP*CP*GP*CP*AP*AP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*TP*TP*GP*CP*GP*TP*TP*GP*CP*GP*CP*TP*CP*AP*CP*TP*GP*CP*CP*G)-3'), Lactose operon repressor | Authors: | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | Deposit date: | 2009-01-30 | Release date: | 2009-05-19 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. J.Mol.Biol., 390, 2009
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