7T2K
 
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6GG3
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7BFZ
 | | X-ray structure of human prostate-specific membrane antigen(PSMA) in complex with a inhibitor Glu-490 | | Descriptor: | (((S)-1-carboxy-5-((E)-2-cyano-3-(5-(1-(3-methoxy-3-oxopropyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)acrylamido)pentyl)carbamoyl)-L-glutamic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Rakhimbekova, A, Motlova, L, Barinka, C. | | Deposit date: | 2021-01-05 | | Release date: | 2021-08-18 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging.
Nat Commun, 12, 2021
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7SXH
 | | BIO-8546 bound GSK3beta-axin complex | | Descriptor: | (4S,5R,8R)-4-ethyl-8-fluoro-4-[3-(3-fluoro-5-methoxypyridin-4-yl)phenyl]-7,7-dimethyl-4,5,6,7,8,9-hexahydro-2H-pyrazolo[3,4-b]quinolin-5-ol, Glycogen synthase kinase-3 beta, axin peptide | | Authors: | Chodaparambil, J.V. | | Deposit date: | 2021-11-23 | | Release date: | 2023-06-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Elucidation of the GSK3 alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
Acs Chem Neurosci, 14, 2023
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7B91
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6HQ3
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7T2J
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8A4D
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7BK4
 | | Crystal structure of RXRalpha ligand binding domain in complex with a fragment of the TIF2 coactivator | | Descriptor: | 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | | Authors: | le Maire, A, Bourguet, W. | | Deposit date: | 2021-01-15 | | Release date: | 2021-08-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).
J.Mol.Biol., 433, 2021
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6XB1
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6XB5
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6OCX
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6C3D
 | | O2-, PLP-dependent L-arginine hydroxylase RohP quinonoid II complex | | Descriptor: | (2E,3E)-5-carbamimidamido-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}pent-3-enoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Hedges, J.B, Ryan, K.S. | | Deposit date: | 2018-01-09 | | Release date: | 2018-03-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Snapshots of the Catalytic Cycle of an O2, Pyridoxal Phosphate-Dependent Hydroxylase.
ACS Chem. Biol., 13, 2018
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7T4U
 | | Crystal Structure of cGMP-dependent Protein Kinase | | Descriptor: | 3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic acid, cGMP-dependent protein kinase 1 | | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | | Deposit date: | 2021-12-10 | | Release date: | 2023-06-14 | | Last modified: | 2023-07-12 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
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8TUU
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7BJ9
 | | Structure of Sfh-I with 2-Mercaptomethyl-thiazolidine L-anti-1a | | Descriptor: | (2~{S},4~{R})-2-ethoxycarbonyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, GLYCEROL, ... | | Authors: | Hinchliffe, P, Spencer, J. | | Deposit date: | 2021-01-14 | | Release date: | 2021-08-25 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.21000588 Å) | | Cite: | 2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-beta-Lactamase Classes by Maintaining a Conserved Binding Mode.
Acs Infect Dis., 7, 2021
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8TUV
 | | Merkel Cell Polyomavirus LTA NLSm bound to importin alpha 2 | | Descriptor: | 30S ribosomal protein S11, Importin subunit alpha-1, SER-ARG-LYS-ARG-LYS-PHE | | Authors: | Cross, E.M, Forwood, J.K, Alvisi, G. | | Deposit date: | 2023-08-17 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals.
Protein Sci., 33, 2024
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8A85
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8U5M
 | | Structure of Sts-1 HP domain with rebamipide | | Descriptor: | Rebamipide, Ubiquitin-associated and SH3 domain-containing protein B | | Authors: | Azia, F, Dey, R, French, J.B. | | Deposit date: | 2023-09-12 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.
J.Med.Chem., 67, 2024
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6OR3
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6H16
 | | Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-D07 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor-related protein 6, ... | | Authors: | Gros, P, van Scherpenzeel, R.C. | | Deposit date: | 2018-07-11 | | Release date: | 2019-01-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
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8A45
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6ORI
 | | Enterococcal surface protein, partial N-terminal region | | Descriptor: | CALCIUM ION, EF0056 | | Authors: | Spiegelman, L, Zhang, L, Tezcan, A, Ghosh, P. | | Deposit date: | 2019-04-30 | | Release date: | 2020-05-13 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Enterococcal surface protein, partial N-terminal region (CASP target)
To Be Published
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7TFF
 | | Crystal structure of human platelet phosphofructokinase-1 mutant- D564N | | Descriptor: | ATP-dependent 6-phosphofructokinase, platelet type, PHOSPHATE ION, ... | | Authors: | Hansen, H, Webb, B.A, Robart, A.R, Narayanasami, S. | | Deposit date: | 2022-01-06 | | Release date: | 2023-07-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.
Biochem.J., 480, 2023
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6BVT
 | | Importin alpha 1 in cargo free state | | Descriptor: | Importin subunit alpha-1 | | Authors: | Smith, K.M, Tsimablyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | | Deposit date: | 2017-12-13 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
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