7TFF

Crystal structure of human platelet phosphofructokinase-1 mutant- D564N

Summary for 7TFF

Entry DOI	10.2210/pdb7tff/pdb
Related	4HR3 4U1R 4WL0 4XYJ 4XYK 4XZ2
Descriptor	ATP-dependent 6-phosphofructokinase, platelet type, PHOSPHATE ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, somatic mutation, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	358583.55
Authors	Hansen, H.,Webb, B.A.,Robart, A.R.,Narayanasami, S. (deposition date: 2022-01-06, release date: 2023-07-12, Last modification date: 2024-01-24)
Primary citation	Voronkova, M.A.,Hansen, H.L.,Cooper, M.P.,Miller, J.,Sukumar, N.,Geldenhuys, W.J.,Robart, A.R.,Webb, B.A. Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity. Biochem.J., 480:1411-1427, 2023 Cited by PubMed: 37622331 DOI: 10.1042/BCJ20230207 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation