4XYK

Crystal structure of human phosphofructokinase-1 in complex with ADP, Northeast Structural Genomics Consortium Target HR9275

Summary for 4XYK

• Entry DOI: 10.2210/pdb4xyk/pdb
• Related: 4XYJ
• Descriptor: ATP-dependent 6-phosphofructokinase, platelet type, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION (3 entities in total)
• Functional Keywords: structural genomics, psi-biology, protein structure initiative, northeast structural genomics consortium, nesg, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q01813
• Total number of polymer chains: 4
• Total formula weight: 359427.36

Authors

Forouhar, F.,Webb, B.A.,Szu, F.-E.,Seetharaman, J.,Barber, D.L.,Tong, L.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2015-02-02, release date: 2015-05-06, Last modification date: 2023-09-27)

• Primary citation: Webb, B.A.,Forouhar, F.,Szu, F.E.,Seetharaman, J.,Tong, L.,Barber, D.L.; Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.; Nature, 523:111-114, 2015; PubMed: 25985179; DOI: 10.1038/nature14405

Experimental method

X-RAY DIFFRACTION (3.4 Å)