PDB: 438 resultsInfo pagesStatus searchChemie searchBIRD

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2WS1	Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form Descriptor: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN Authors: Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. Deposit date: 2009-09-03 Release date: 2010-02-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
2WS6	Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form Descriptor: CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... Authors: Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. Deposit date: 2009-09-03 Release date: 2010-02-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
1BPH	CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Descriptor: 1,2-DICHLOROETHANE, INSULIN A CHAIN (PH 9), INSULIN B CHAIN (PH 9), ... Authors: Gursky, O, Badger, J, Li, Y, Caspar, D.L.D. Deposit date: 1992-10-30 Release date: 1993-01-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Conformational changes in cubic insulin crystals in the pH range 7-11. Biophys.J., 63, 1992
1BOM	THREE-DIMENSIONAL STRUCTURE OF BOMBYXIN-II, AN INSULIN-RELATED BRAIN-SECRETORY PEPTIDE OF THE SILKMOTH BOMBYX MORI: COMPARISON WITH INSULIN AND RELAXIN Descriptor: BOMBYXIN-II,BOMBYXIN A-2, BOMBYXIN-II,BOMBYXIN A-6 Authors: Nagata, K, Hatanaka, H, Kohda, D, Inagaki, F. Deposit date: 1994-07-21 Release date: 1994-11-01 Last modified: 2019-12-25 Method: SOLUTION NMR Cite: Three-dimensional solution structure of bombyxin-II an insulin-like peptide of the silkmoth Bombyx mori: structural comparison with insulin and relaxin. J.Mol.Biol., 253, 1995
1CPH	CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Descriptor: 1,2-DICHLOROETHANE, INSULIN (PH 10), SODIUM ION Authors: Gursky, O, Badger, J, Li, Y, Caspar, D.L.D. Deposit date: 1992-10-30 Release date: 1993-01-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Conformational changes in cubic insulin crystals in the pH range 7-11. Biophys.J., 63, 1992
4AJZ	Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. Deposit date: 2012-02-21 Release date: 2013-01-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
4AJX	Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin Descriptor: IMIDAZOLE, INSULIN, N-(16-Carboxyhexadecanoyl)-L-glutamic acid, ... Authors: Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. Deposit date: 2012-02-20 Release date: 2013-01-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
1EV3	Structure of the rhombohedral form of the M-cresol/insulin R6 hexamer Descriptor: CHLORIDE ION, INSULIN, M-CRESOL, ... Authors: Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. Deposit date: 2000-04-19 Release date: 2000-12-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.78 Å) Cite: R6 hexameric insulin complexed with m-cresol or resorcinol. Acta Crystallogr.,Sect.D, 56, 2000
5USP	Insulin with proline analog Pip at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.174 Å) Cite: Insulin with proline analog Pip at position B28 in the T2 state To Be Published
5USS	Insulin with proline analog PiP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.061 Å) Cite: Insulin with proline analog PiP at position B28 in the R6 state To Be Published
5UU4	Insulin with proline analog ThioP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.973 Å) Cite: Insulin with proline analog ThioP at position B28 in the R6 state To Be Published
5UU2	Insulin with proline analog ThioP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-15 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.223 Å) Cite: Insulin with proline analog ThioP at position B28 in the T2 state To Be Published
5URU	Insulin with proline analog DhP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Insulin with proline analog DhP at position B28 in the R6 state To Be Published
4AK0	Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. Deposit date: 2012-02-21 Release date: 2013-01-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
4A7E	X-ray crystal structure of porcine insulin flash-cooled at high pressure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Burkhardt, A, Warmer, M, Panneerselvam, S, Wagner, A, Reimer, R, Hohenberg, H, Meents, A. Deposit date: 2011-11-14 Release date: 2011-11-30 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.856 Å) Cite: Fast High-Pressure Freezing of Protein Crystals in Their Mother Liquor Acta Crystallogr.,Sect.F, 68, 2012
4AKJ	Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. Deposit date: 2012-02-23 Release date: 2013-01-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
1EVR	The structure of the resorcinol/insulin R6 hexamer Descriptor: CHLORIDE ION, INSULIN, RESORCINOL, ... Authors: Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. Deposit date: 2000-04-20 Release date: 2000-12-04 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: R6 hexameric insulin complexed with m-cresol or resorcinol. Acta Crystallogr.,Sect.D, 56, 2000
5WDM	An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein Descriptor: Single-chain insulin analog Authors: Yee, V.C, Aldabbagh, K, Peng, Y. Deposit date: 2017-07-05 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.803 Å) Cite: An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293, 2018
3ZI3	Crystal structure of the B24His-insulin - human analogue Descriptor: INSULIN, SULFATE ION Authors: Zakova, L, Kletvikova, E, Veverka, V, Lepsik, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2013-01-02 Release date: 2013-03-06 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Integrity of the B24 Site in Human Insulin is Important for Hormone Functionality J.Biol.Chem., 288, 2013
5UOZ	Insulin with proline analog FyP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-01 Release date: 2018-02-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.17463875 Å) Cite: Insulin with proline analog FyP at position B28 in the T2 state To Be Published
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING Descriptor: Insulin Authors: Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. Deposit date: 2017-06-29 Release date: 2017-11-15 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018
4AIY	R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'GREEN' SUBSTATE, AVERAGE STRUCTURE Descriptor: PHENOL, PROTEIN (INSULIN) Authors: O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. Deposit date: 1998-12-29 Release date: 2000-02-28 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
5USV	Insulin with proline analog AzeP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-14 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Insulin with proline analog AzeP at position B28 in the T2 state To Be Published
5VIZ	X-Ray structure of Insulin Glargine Descriptor: Insulin, chain alpha, chain beta Authors: Reyes-Grajeda, J.P, Romero, A. Deposit date: 2017-04-17 Release date: 2017-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: X-Ray structure of Insulin Glargine To Be Published
3ZQR	NMePheB25 insulin analogue crystal structure Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Antolikova, E, Zakova, L, Turkenburg, J.P, Watson, C.J, Hanclova, I, Sanda, M, Cooper, A, Kraus, T, Brzozowski, A.M, Jiracek, J.A. Deposit date: 2011-06-10 Release date: 2011-08-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface. J.Biol.Chem., 286, 2011

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