8HB0
 
 | | Structure of human SGLT2-MAP17 complex with TA1887 | | Descriptor: | (2R,3R,4S,5S,6R)-2-[3-[(4-cyclopropylphenyl)methyl]-4-fluoranyl-indol-1-yl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-10-27 | | Release date: | 2023-11-01 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
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1KA0
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2BF4
 | | A second FMN-binding site in yeast NADPH-cytochrome P450 reductase suggests a novel mechanism of electron transfer by diflavin reductases. | | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Podust, L.M, Lepesheva, G.I, Kim, Y, Yermalitskaya, L.V, Yermalitsky, V.N, Lamb, D.C, Kelly, S.L, Waterman, M.R. | | Deposit date: | 2004-12-03 | | Release date: | 2006-01-17 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A Second Fmn-Binding Site in Yeast Nadph-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases.
Structure, 14, 2006
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2DHC
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1K9R
 | | YAP65 WW domain complexed to Acetyl-PLPPY | | Descriptor: | 65 kDa Yes-associated protein, WW domain binding protein-1 | | Authors: | Pires, J.R, Taha-Nejad, F, Toepert, F, Ast, T, Hoffmuller, U, Schneider-Mergener, J, Kuhne, R, Macias, M.J, Oschkinat, H. | | Deposit date: | 2001-10-30 | | Release date: | 2001-12-28 | | Last modified: | 2021-11-10 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.
J.Mol.Biol., 314, 2001
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8GW7
 | | AtSLAC1 6D mutant in open state | | Descriptor: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment) | | Authors: | Lee, Y, Lee, S. | | Deposit date: | 2022-09-16 | | Release date: | 2023-11-15 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
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8HGF
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8HG7
 | | Structure of human SGLT2-MAP17 complex with Sotagliflozin | | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-14 | | Release date: | 2023-11-15 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
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8HEZ
 | | Structure of human SGLT2-MAP17 complex with Dapagliflozin | | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-09 | | Release date: | 2023-11-15 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
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8HDH
 | | Structure of human SGLT2-MAP17 complex with Canagliflozin | | Descriptor: | (2~{S},3~{R},4~{R},5~{S},6~{R})-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methyl-phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-04 | | Release date: | 2023-11-08 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
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8GW6
 | | AtSLAC1 6D mutant in closed state | | Descriptor: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment) | | Authors: | Lee, Y, Lee, S. | | Deposit date: | 2022-09-16 | | Release date: | 2023-11-15 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
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8HNN
 | | Structure of CXCR3 complexed with antagonist SCH546738 | | Descriptor: | 3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide, CHOLESTEROL, Nb6, ... | | Authors: | Jiao, H.Z, Hu, H.L. | | Deposit date: | 2022-12-08 | | Release date: | 2023-11-29 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural insights into the activation and inhibition of CXC chemokine receptor 3.
Nat.Struct.Mol.Biol., 31, 2024
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2DGV
 | | Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein M | | Descriptor: | Heterogeneous nuclear ribonucleoprotein M | | Authors: | Abe, C, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-03-16 | | Release date: | 2006-09-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein M
To be Published
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8HIN
 | | Structure of human SGLT2-MAP17 complex with Phlorizin | | Descriptor: | 1-[2-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,6-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-21 | | Release date: | 2023-11-22 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
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1K4D
 | | Potassium Channel KcsA-Fab complex in low concentration of K+ | | Descriptor: | DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... | | Authors: | Zhou, Y, Morais-Cabral, J.H, Kaufman, A, MacKinnon, R. | | Deposit date: | 2001-10-07 | | Release date: | 2001-11-14 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature, 414, 2001
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1K5P
 | | Hydrolytic haloalkane dehalogenase LINB from sphingomonas paucimobilis UT26 at 1.8A resolution | | Descriptor: | 1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase, CHLORIDE ION, MAGNESIUM ION | | Authors: | Streltsov, V.A, Damborsky, J, Wilce, M.C.J. | | Deposit date: | 2001-10-12 | | Release date: | 2003-08-26 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates
Biochemistry, 42, 2003
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1KB0
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8HOK
 | | crystal structure of UGT71AP2 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, UGT71AP2 | | Authors: | Wang, Z.L, He, C, Li, F, Qiao, X, Ye, M. | | Deposit date: | 2022-12-10 | | Release date: | 2023-12-13 | | Last modified: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Functional characterization, structural basis, and protein engineering of a rare flavonoid 2'- O -glycosyltransferase from Scutellaria baicalensis .
Acta Pharm Sin B, 14, 2024
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1KPH
 | | Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMAB | | Descriptor: | CARBONATE ION, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1, DIDECYL-DIMETHYL-AMMONIUM, ... | | Authors: | Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2001-12-30 | | Release date: | 2002-01-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
J.Biol.Chem., 277, 2002
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2DHF
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2DHO
 | | Crystal structure of human IPP isomerase I in space group P212121 | | Descriptor: | CHLORIDE ION, Isopentenyl-diphosphate delta-isomerase 1, MANGANESE (II) ION, ... | | Authors: | Zhang, C, Wei, Z, Gong, W. | | Deposit date: | 2006-03-24 | | Release date: | 2007-06-05 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of human IPP isomerase: new insights into the catalytic mechanism
J.Mol.Biol., 366, 2007
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1KQN
 | | Crystal structure of NMN/NaMN adenylyltransferase complexed with NAD | | Descriptor: | NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, XENON | | Authors: | Zhou, T, Kurnasov, O, Tomchick, D.R, Binns, D.D, Grishin, N.V, Marquez, V.E, Osterman, A.L, Zhang, H. | | Deposit date: | 2002-01-07 | | Release date: | 2003-01-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of Human Nicotinamide/Nicotonic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2003
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2DIE
 | | Alkaline alpha-amylase AmyK from Bacillus sp. KSM-1378 | | Descriptor: | CALCIUM ION, SODIUM ION, amylase | | Authors: | Shirai, T, Igarashi, K, Ozawa, T, Hagihara, H, Kobayashi, T, Ozaki, K, Ito, S. | | Deposit date: | 2006-03-29 | | Release date: | 2007-02-13 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Ancestral sequence evolutionary trace and crystal structure analyses of alkaline alpha-amylase from Bacillus sp. KSM-1378 to clarify the alkaline adaptation process of proteins
Proteins, 66, 2007
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1KC6
 | | HincII Bound to Cognate DNA | | Descriptor: | 5'-D(P*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3', SODIUM ION, TYPE II RESTRICTION ENZYME HINCII | | Authors: | Horton, N.C, Dorner, L.F, Perona, J.J. | | Deposit date: | 2001-11-07 | | Release date: | 2001-12-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation.
Nat.Struct.Biol., 9, 2002
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1JCR
 | | CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE | | Descriptor: | ACETIC ACID, FARNESYL DIPHOSPHATE, PROTEIN FARNESYLTRANSFERASE, ... | | Authors: | Long, S.B, Casey, P.J, Beese, L.S. | | Deposit date: | 2001-06-11 | | Release date: | 2001-11-02 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
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