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6P0S
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BU of 6p0s by Molmil
Crystal structure of ternary DNA complex "FX2" containing E. coli Fis and phage lambda Xis
Descriptor: DNA (27-MER), FX1-2, DNA-binding protein Fis, ...
Authors:Hancock, S.P, Cascio, D, Johnson, R.C.
Deposit date:2019-05-17
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cooperative DNA binding by proteins through DNA shape complementarity.
Nucleic Acids Res., 47, 2019
2W96
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BU of 2w96 by Molmil
Crystal Structure of CDK4 in complex with a D-type cyclin
Descriptor: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1, GLYCEROL
Authors:Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H.
Deposit date:2009-01-21
Release date:2009-03-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
4GD7
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BU of 4gd7 by Molmil
Wild-Type Human Thymidylate Synthase with bound Purpurogallin
Descriptor: 1,2-ETHANEDIOL, 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one, SULFATE ION, ...
Authors:Celeste, L.R, Lebioda, L.
Deposit date:2012-07-31
Release date:2013-07-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Oxidation of Cysteine 195 of Huyman Thymidylate Synthase by Purpurogallin
To be published, 2012
4KPW
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BU of 4kpw by Molmil
Crystal structure of His-tagged human thymidylate synthase R175A mutant
Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase
Authors:Pozzi, C, Mangani, S.
Deposit date:2013-05-14
Release date:2014-05-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
J.Med.Chem., 58, 2015
4JEF
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BU of 4jef by Molmil
Crystal structure of human thymidylate synthase Y202A in inactive conformation.
Descriptor: SULFATE ION, Thymidylate synthase
Authors:Tochowicz, A, Stroud, R.M, Wade, R.C.
Deposit date:2013-02-26
Release date:2014-08-20
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.311 Å)
Cite:Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
J.Med.Chem., 58, 2015
3BRI
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BU of 3bri by Molmil
Crystal Structure of apo-LC8
Descriptor: ACETATE ION, Dynein light chain 1, cytoplasmic, ...
Authors:Benison, G, Karplus, P.A, Barbar, E, Chiodo, M.
Deposit date:2007-12-21
Release date:2008-12-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Interplay of Ligand Binding and Quaternary Structure in the Diverse Interactions of Dynein Light Chain LC8.
J.Mol.Biol., 384, 2008
4FGT
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BU of 4fgt by Molmil
Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.
Descriptor: CG peptide, SULFATE ION, Thymidylate synthase
Authors:Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P.
Deposit date:2012-06-04
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.
J.Med.Chem., 58, 2015
2FO1
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BU of 2fo1 by Molmil
Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA
Descriptor: 5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3', 5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3', Lin-12 and glp-1 phenotype protein 1, ...
Authors:Wilson, J.J, Kovall, R.A.
Deposit date:2006-01-12
Release date:2006-03-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.
Cell(Cambridge,Mass.), 124, 2006
5DTD
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BU of 5dtd by Molmil
Crystal structure of Fis bound to 27bp DNA F1-8C (AAATTCGTTTGAATTTTGAGCGAATTT)
Descriptor: DNA (27-MER), DNA-binding protein Fis
Authors:Hancock, S.P, Cascio, D, Johnson, R.C.
Deposit date:2015-09-17
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.642 Å)
Cite:DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.
Plos One, 11, 2016
6QXH
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BU of 6qxh by Molmil
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Pozzi, C, Mangani, M.
Deposit date:2019-03-07
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules, 24, 2019
5E3L
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BU of 5e3l by Molmil
Crystal structure of Fis bound to 27bp DNA F1-8G (AAATTGGTTTGAATTTTGAGCCAATTT)
Descriptor: DNA (27-MER), DNA-binding protein Fis
Authors:Hancock, S.P, Cascio, D, Johnson, R.C.
Deposit date:2015-10-03
Release date:2016-03-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.
Plos One, 11, 2016
6QXG
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BU of 6qxg by Molmil
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with FdUMP
Descriptor: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, Thymidylate synthase
Authors:Pozzi, C, Mangani, M.
Deposit date:2019-03-07
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules, 24, 2019
5DS9
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BU of 5ds9 by Molmil
Crystal structure of Fis bound to 27bp DNA F1-8A (AAATTAGTTTGAATTTTGAGCTAATTT)
Descriptor: DNA (27-MER), DNA-binding protein Fis
Authors:Hancock, S.P, Cascio, D, Johnson, R.C.
Deposit date:2015-09-17
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.561 Å)
Cite:DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.
Plos One, 11, 2016
5DV2
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BU of 5dv2 by Molmil
Crystal structure of human CNOT6L in complex with cytidine-5'-monophosphate
Descriptor: CCR4-NOT transcription complex subunit 6-like, CYTIDINE-5'-MONOPHOSPHATE
Authors:Zhang, Q, Bartlam, M.
Deposit date:2015-09-21
Release date:2016-05-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural basis for inhibition of the deadenylase activity of human CNOT6L
Febs Lett., 590, 2016
5E3N
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BU of 5e3n by Molmil
Crystal structure of Fis bound to 27bp DNA F31 (AAATTTGTAGGAATTTTCTGCAAATTT)
Descriptor: DNA (27-MER), DNA-binding protein Fis
Authors:Hancock, S.P, Cascio, D, Johnson, R.C.
Deposit date:2015-10-03
Release date:2016-03-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.
Plos One, 11, 2016
5E3O
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BU of 5e3o by Molmil
Crystal structure of Fis bound to 27bp DNA F32 (AAATTTGGAGGAATTTTCTCCAAATTT)
Descriptor: DNA (27-MER), DNA-binding protein Fis
Authors:Hancock, S.P, Cascio, D, Johnson, R.C.
Deposit date:2015-10-03
Release date:2016-03-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.
Plos One, 11, 2016
4GYH
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BU of 4gyh by Molmil
Structure of human thymidylate synthase at high salt conditions
Descriptor: SULFATE ION, Thymidylate synthase
Authors:Brunn, N, Dibrov, S, Hermann, T.
Deposit date:2012-09-05
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Analysis of mRNA recognition by human thymidylate synthase.
Biosci.Rep., 34, 2014
5DC3
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BU of 5dc3 by Molmil
Complex of yeast 80S ribosome with non-modified eIF5A
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-23
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.
J.Mol.Biol., 428, 2016
5CY2
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BU of 5cy2 by Molmil
Tn3 resolvase - site III complex crystal form II
Descriptor: DNA (27-MER), Transposon Tn3 resolvase
Authors:Montano, P.S, Rice, P.A.
Deposit date:2015-07-30
Release date:2017-01-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of resolvase - accessory site complexes
To Be Published
5W43
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BU of 5w43 by Molmil
Structure of the two-component response regulator RcsB-DNA complex
Descriptor: DNA (5'-D(*GP*AP*TP*TP*TP*AP*GP*GP*AP*AP*AP*AP*AP*TP*CP*TP*TP*AP*GP*AP*TP*A)-3'), DNA (5'-D(*TP*AP*TP*CP*TP*AP*AP*GP*AP*TP*TP*TP*TP*TP*CP*CP*TP*AP*AP*AP*TP*C)-3'), Transcriptional regulatory protein RcsB
Authors:Filippova, E.V, Warwzak, Z, Pshenychnyi, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-06-09
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural Basis for DNA Recognition by the Two-Component Response Regulator RcsB.
MBio, 9, 2018
6P0U
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BU of 6p0u by Molmil
Crystal structure of ternary DNA complex " FX(1-2)-2Xis" containing E. coli Fis and phage lambda Xis
Descriptor: DNA (27-MER), FX1-2, DNA-binding protein Fis, ...
Authors:Hancock, S.P, Cascio, D, Johnson, R.C.
Deposit date:2019-05-17
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Cooperative DNA binding by proteins through DNA shape complementarity.
Nucleic Acids Res., 47, 2019
5EB2
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BU of 5eb2 by Molmil
Trp-bound YfiR
Descriptor: SULFATE ION, TRYPTOPHAN, YfiR
Authors:Xu, M, Yang, X, Yang, X.-A, Zhou, L, Liu, T.-Z, Fan, Z, Jiang, T.
Deposit date:2015-10-17
Release date:2016-05-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.709 Å)
Cite:Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system
Protein Cell, 7, 2016
5DV4
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BU of 5dv4 by Molmil
Crystal structure of human CNOT6L in complex with neomycin
Descriptor: CCR4-NOT transcription complex subunit 6-like, NEOMYCIN, SULFATE ION
Authors:Zhang, Q, Bartlam, M.
Deposit date:2015-09-21
Release date:2016-10-26
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for inhibition of the deadenylase activity of human CNOT6L
Febs Lett., 590, 2016
3DVT
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BU of 3dvt by Molmil
Biochemical and structural characterization of the PAK1- LC8 interaction
Descriptor: Dynein light chain 1, cytoplasmic
Authors:LIghtcap, C.M, Williams, J.C.
Deposit date:2008-07-20
Release date:2009-05-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biochemical and structural characterization of the Pak1-LC8 interaction.
J.Biol.Chem., 283, 2008
3DVH
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BU of 3dvh by Molmil
LC8 Point mutant K36P
Descriptor: Dynein light chain 1, cytoplasmic
Authors:Lightcap, C.M, Williams, J.C.
Deposit date:2008-07-18
Release date:2009-01-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biochemical and structural characterization of the Pak1-LC8 interaction.
J.Biol.Chem., 283, 2008

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数据于2024-08-28公开中

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