7QE8
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![BU of 7qe8 by Molmil](/molmil-images/mine/7qe8) | Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 (SPINK1) | Descriptor: | SULFATE ION, Serine protease inhibitor Kazal-type 1, Trypsin-1 | Authors: | Nagel, F, Palm, G.J, Delcea, M, Lammers, M. | Deposit date: | 2021-12-01 | Release date: | 2022-03-30 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin. Int J Mol Sci, 23, 2022
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7GCH
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![BU of 7gch by Molmil](/molmil-images/mine/7gch) | STRUCTURE OF CHYMOTRYPSIN-*TRIFLUOROMETHYL KETONE INHIBITOR COMPLEXES. COMPARISON OF SLOWLY AND RAPIDLY EQUILIBRATING INHIBITORS | Descriptor: | 1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE), GAMMA-CHYMOTRYPSIN A | Authors: | Brady, K, Ringe, D, Abeles, R.H. | Deposit date: | 1990-04-06 | Release date: | 1990-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors. Biochemistry, 29, 1990
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7JWX
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![BU of 7jwx by Molmil](/molmil-images/mine/7jwx) | Crystal Structure of Trypsin Bound O-methyl Benzamidine | Descriptor: | 4-[(1-{(1S,2S)-1-[1-(4-aminobutyl)-1H-1,2,3-triazol-4-yl]-2-methylbutyl}-1H-1,2,3-triazol-4-yl)methoxy]-3-methoxybenzene-1-carboximidamide, CALCIUM ION, CHLORIDE ION, ... | Authors: | Packianathan, C, Laganowsky, A. | Deposit date: | 2020-08-26 | Release date: | 2021-08-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Small molecule peptidomimetic trypsin inhibitors: validation of an EKO binding mode, but with a twist. Org.Biomol.Chem., 20, 2022
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5TP0
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![BU of 5tp0 by Molmil](/molmil-images/mine/5tp0) | Human mesotrypsin in complex with diminazene | Descriptor: | BERENIL, CALCIUM ION, SULFATE ION, ... | Authors: | Kayode, O, Soares, A, Radisky, E.S. | Deposit date: | 2016-10-19 | Release date: | 2017-05-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Small molecule inhibitors of mesotrypsin from a structure-based docking screen. PLoS ONE, 12, 2017
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5PTI
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![BU of 5pti by Molmil](/molmil-images/mine/5pti) | |
4J2Y
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![BU of 4j2y by Molmil](/molmil-images/mine/4j2y) | |
5GIB
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![BU of 5gib by Molmil](/molmil-images/mine/5gib) | Succinic acid bound trypsin crystallized as dimer | Descriptor: | CALCIUM ION, Cationic trypsin, SUCCINIC ACID | Authors: | Kutumbarao, N.H.V, Manohar, R, KarthiK, L, Malathy, P, Gunasekaran, K, Velmurugan, D. | Deposit date: | 2016-06-22 | Release date: | 2016-08-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.697 Å) | Cite: | Trypsin bound with Succinic acid To Be Published
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6DWU
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7PTI
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6DWH
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![BU of 6dwh by Molmil](/molmil-images/mine/6dwh) | Crystal structure of complex of BBKI and Bovine Trypsin | Descriptor: | CHLORIDE ION, Cationic trypsin, Kunitz-type inihibitor, ... | Authors: | Li, M, Wlodawer, A. | Deposit date: | 2018-06-26 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes. Acta Crystallogr D Struct Biol, 75, 2019
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6DWF
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4GUX
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![BU of 4gux by Molmil](/molmil-images/mine/4gux) | Crystal structure of trypsin:MCoTi-II complex | Descriptor: | ACETATE ION, CALCIUM ION, Cationic trypsin, ... | Authors: | King, G.J, Daly, N.L, Thorstholm, L, Greenwood, K.P, Rosengren, K.J, Heras, B, Craik, D.J, Martin, J.L. | Deposit date: | 2012-08-30 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor J.Biol.Chem., 288, 2013
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4HGC
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![BU of 4hgc by Molmil](/molmil-images/mine/4hgc) | Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1 | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Krzywda, S, Jaskolski, M, Rolka, K, Stawikowski, M. | Deposit date: | 2012-10-08 | Release date: | 2013-10-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Structure of a proteolytically resistant analogue of (NLys)(5)SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysis. Acta Crystallogr.,Sect.D, 70, 2014
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4AOQ
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![BU of 4aoq by Molmil](/molmil-images/mine/4aoq) | Cationic trypsin in complex with mutated Spinacia oleracea trypsin inhibitor III (SOTI-III) (F14A) | Descriptor: | CALCIUM ION, CATIONIC TRYPSIN, PENTAETHYLENE GLYCOL, ... | Authors: | Schmelz, S, Glotzbach, B, Reinwarth, M, Christmann, A, Kolmar, H, Heinz, D.W. | Deposit date: | 2012-03-29 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Characterization of Spinacia Oleracea Trypsin Inhibitor III (Soti-III) Acta Crystallogr.,Sect.D, 69, 2013
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4AOR
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![BU of 4aor by Molmil](/molmil-images/mine/4aor) | Cationic trypsin in complex with the Spinacia oleracea trypsin inhibitor III (SOTI-III) | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Schmelz, S, Glotzbach, B, Reinwarth, M, Christmann, A, Kolmar, H, Heinz, D.W. | Deposit date: | 2012-03-29 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Structural Characterization of Spinacia Oleracea Trypsin Inhibitor III (Soti-III) Acta Crystallogr.,Sect.D, 69, 2013
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6BX8
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![BU of 6bx8 by Molmil](/molmil-images/mine/6bx8) | Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) | Descriptor: | SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3 | Authors: | Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S. | Deposit date: | 2017-12-18 | Release date: | 2019-02-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J. Biol. Chem., 294, 2019
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4I8G
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![BU of 4i8g by Molmil](/molmil-images/mine/4i8g) | Bovine trypsin at 0.8 resolution | Descriptor: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | Authors: | Dauter, Z, Liebschner, D, Dauter, M, Brzuszkiewicz, A. | Deposit date: | 2012-12-03 | Release date: | 2012-12-19 | Last modified: | 2013-09-18 | Method: | X-RAY DIFFRACTION (0.8 Å) | Cite: | On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin. Acta Crystallogr.,Sect.D, 69, 2013
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1AVX
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![BU of 1avx by Molmil](/molmil-images/mine/1avx) | COMPLEX PORCINE PANCREATIC TRYPSIN/SOYBEAN TRYPSIN INHIBITOR, TETRAGONAL CRYSTAL FORM | Descriptor: | CALCIUM ION, TRYPSIN, TRYPSIN INHIBITOR | Authors: | Song, H.K, Suh, S.W. | Deposit date: | 1997-09-21 | Release date: | 1998-10-28 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator. J.Mol.Biol., 275, 1998
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4I8H
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![BU of 4i8h by Molmil](/molmil-images/mine/4i8h) | Bovine trypsin at 0.75 resolution | Descriptor: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | Authors: | Dauter, Z, Liebschner, D, Dauter, M, Brzuszkiewicz, A. | Deposit date: | 2012-12-03 | Release date: | 2012-12-19 | Last modified: | 2013-09-18 | Method: | X-RAY DIFFRACTION (0.75 Å) | Cite: | On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin. Acta Crystallogr.,Sect.D, 69, 2013
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4I8K
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![BU of 4i8k by Molmil](/molmil-images/mine/4i8k) | Bovine trypsin at 0.85 resolution | Descriptor: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | Authors: | Dauter, Z, Liebschner, D, Dauter, M, Brzuszkiewicz, A. | Deposit date: | 2012-12-03 | Release date: | 2012-12-19 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin. Acta Crystallogr.,Sect.D, 69, 2013
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4I8J
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![BU of 4i8j by Molmil](/molmil-images/mine/4i8j) | Bovine trypsin at 0.87 A resolution | Descriptor: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | Authors: | Dauter, Z, Liebschner, D, Dauter, M, Brzuszkiewicz, A. | Deposit date: | 2012-12-03 | Release date: | 2012-12-19 | Last modified: | 2013-09-18 | Method: | X-RAY DIFFRACTION (0.87 Å) | Cite: | On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin. Acta Crystallogr.,Sect.D, 69, 2013
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4I8L
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![BU of 4i8l by Molmil](/molmil-images/mine/4i8l) | Bovine trypsin at 0.87 resolution | Descriptor: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | Authors: | Dauter, Z, Liebschner, D, Dauter, M, Brzuszkiewicz, A. | Deposit date: | 2012-12-03 | Release date: | 2012-12-19 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (0.87 Å) | Cite: | On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin. Acta Crystallogr.,Sect.D, 69, 2013
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4J2K
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![BU of 4j2k by Molmil](/molmil-images/mine/4j2k) | Crystal structure of a plant trypsin inhibitor EcTI | Descriptor: | GLYCEROL, IMIDAZOLE, Trypsin inhibitor | Authors: | Zhou, D, Wlodawer, A. | Deposit date: | 2013-02-04 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structures of a Plant Trypsin Inhibitor from Enterolobium contortisiliquum (EcTI) and of Its Complex with Bovine Trypsin. Plos One, 8, 2013
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6GCH
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![BU of 6gch by Molmil](/molmil-images/mine/6gch) | STRUCTURE OF CHYMOTRYPSIN-*TRIFLUOROMETHYL KETONE INHIBITOR COMPLEXES. COMPARISON OF SLOWLY AND RAPIDLY EQUILIBRATING INHIBITORS | Descriptor: | 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE), GAMMA-CHYMOTRYPSIN A | Authors: | Brady, K, Wei, A, Ringe, D, Abeles, R.H. | Deposit date: | 1990-04-06 | Release date: | 1990-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors. Biochemistry, 29, 1990
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3TGI
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![BU of 3tgi by Molmil](/molmil-images/mine/3tgi) | WILD-TYPE RAT ANIONIC TRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) | Descriptor: | BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ... | Authors: | Pasternak, A, Ringe, D, Hedstrom, L. | Deposit date: | 1998-07-15 | Release date: | 1998-12-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Comparison of Anionic and Cationic Trypsinogens: The Anionic Activation Domain is More Flexible in Solution and Differs in its Mode of Bpti Binding in the Crystal Structure Protein Sci., 8, 1999
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