7JWX

Crystal Structure of Trypsin Bound O-methyl Benzamidine

Summary for 7JWX

Entry DOI	10.2210/pdb7jwx/pdb
Descriptor	Cationic trypsin, 4-[(1-{(1S,2S)-1-[1-(4-aminobutyl)-1H-1,2,3-triazol-4-yl]-2-methylbutyl}-1H-1,2,3-triazol-4-yl)methoxy]-3-methoxybenzene-1-carboximidamide, CALCIUM ION, ... (7 entities in total)
Functional Keywords	hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bos taurus (Bovine)
Total number of polymer chains	4
Total formula weight	95826.94
Authors	Packianathan, C.,Laganowsky, A. (deposition date: 2020-08-26, release date: 2021-08-04, Last modification date: 2023-10-18)
Primary citation	Lyu, R.L.,Joy, S.,Packianathan, C.,Laganowsky, A.,Burgess, K. Small molecule peptidomimetic trypsin inhibitors: validation of an EKO binding mode, but with a twist. Org.Biomol.Chem., 20:2075-2080, 2022 Cited by PubMed: 35225309 DOI: 10.1039/d1ob02127c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.38 Å)

Structure validation