2DLH
 
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2DOC
 | | Solution structure of the Fibronectin type-III domain of human Neural cell adhesion molecule 2 | | Descriptor: | Neural cell adhesion molecule 2 | | Authors: | Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-04-28 | | Release date: | 2006-10-28 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Fibronectin type-III domain of human Neural cell adhesion molecule 2
To be Published
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2DN7
 | | Solution structures of the 6th fn3 domain of human receptor-type tyrosine-protein phosphatase F | | Descriptor: | Receptor-type tyrosine-protein phosphatase F | | Authors: | Sato, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-04-25 | | Release date: | 2006-10-25 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the 6th fn3 domain of human receptor-type tyrosine-protein phosphatase F
To be Published
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2DM4
 | | Solution structure of the second fn3 domain of human sorLA/LR11 | | Descriptor: | Sortilin-related receptor | | Authors: | Nagashima, T, Kurosaki, C, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-04-20 | | Release date: | 2006-10-20 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the second fn3 domain of human sorLA/LR11
To be Published
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2EDB
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2E7H
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4URT
 | | The crystal structure of a fragment of netrin-1 in complex with FN5- FN6 of DCC | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Finci, L.I, Krueger, N, Sun, X, Zhang, J, Chegkazi, M, Wu, Y, Schenk, G, Mertens, H.D.T, Svergun, D.I, Zhang, Y, Wang, J.-h, Meijers, R. | | Deposit date: | 2014-07-02 | | Release date: | 2014-09-10 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The Crystal Structure of Netrin-1 in Complex with Dcc Reveals the Bi-Functionality of Netrin-1 as a Guidance Cue
Neuron, 83, 2014
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1F6F
 | | CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR | | Descriptor: | PLACENTAL LACTOGEN, PROLACTIN RECEPTOR | | Authors: | Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. | | Deposit date: | 2000-06-21 | | Release date: | 2000-07-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
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3HHR
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7K7J
 | | EphB6 receptor ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 6 | | Authors: | Goldgur, Y, Himanen, J. | | Deposit date: | 2020-09-22 | | Release date: | 2021-04-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.004 Å) | | Cite: | Structure of the EphB6 receptor ectodomain.
Plos One, 16, 2021
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8VJC
 | | Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. | | Descriptor: | Insulin-like growth factor II, Isoform Short of Insulin receptor | | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | | Deposit date: | 2024-01-06 | | Release date: | 2024-03-27 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
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8VJB
 | | Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | | Descriptor: | Insulin-like growth factor II, Isoform Short of Insulin receptor | | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | | Deposit date: | 2024-01-06 | | Release date: | 2024-03-27 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
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5XWT
 | | Crystal structure of PTPdelta Ig1-Fn1 in complex with SALM5 LRR-Ig | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S. | | Deposit date: | 2017-06-30 | | Release date: | 2018-06-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.178 Å) | | Cite: | Structural basis of trans-synaptic interactions between PTP delta and SALMs for inducing synapse formation.
Nat Commun, 9, 2018
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7QID
 | | tentative model of the human insulin receptor ectodomain bound by three insulin | | Descriptor: | Insulin, Insulin receptor, Isoform Short of Insulin receptor | | Authors: | Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. | | Deposit date: | 2021-12-14 | | Release date: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
J Cell Biol, 219, 2020
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7S7K
 | | Crystal structure of the EphB2 extracellular domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 2, ... | | Authors: | Xu, Y, Xu, K, Nikolov, D.B. | | Deposit date: | 2021-09-16 | | Release date: | 2021-10-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism.
Int J Mol Sci, 22, 2021
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5U8R
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5U8Q
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6YGN
 | | Titin kinase and its flanking domains | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Titin | | Authors: | Fleming, J.R, Franke, B, Bogomolovas, J, Mayans, O. | | Deposit date: | 2020-03-27 | | Release date: | 2021-04-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere.
Embo Rep., 22, 2021
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3UP1
 | | Crystal structure of the unliganded human interleukin-7 receptor extracellular domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | McElroy, C.A, Holland, P.J, Walsh, S.T.R. | | Deposit date: | 2011-11-17 | | Release date: | 2012-02-08 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural reorganization of the interleukin-7 signaling complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3UTO
 | | Twitchin kinase region from C.elegans (Fn31-NL-kin-CRD-Ig26) | | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Castelmur, E, Barbieri, S, Mayans, O. | | Deposit date: | 2011-11-26 | | Release date: | 2012-08-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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8FN9
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6ZZ8
 | | MB_CRS6-15 bound to CrSAS-6_6HR | | Descriptor: | Centriole protein, Protein B | | Authors: | Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P. | | Deposit date: | 2020-08-04 | | Release date: | 2021-07-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.73 Å) | | Cite: | Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly.
Nat Commun, 12, 2021
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8G4L
 | | Cryo-EM structure of the human cardiac myosin filament | | Descriptor: | Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... | | Authors: | Dutta, D, Nguyen, V, Padron, R, Craig, R. | | Deposit date: | 2023-02-10 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | Cryo-EM structure of the human cardiac myosin filament.
Nature, 623, 2023
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8GUY
 | | human insulin receptor bound with two insulin molecules | | Descriptor: | Insulin A chain, Insulin, isoform 2, ... | | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | Deposit date: | 2022-09-14 | | Release date: | 2022-11-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
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6BRB
 | | Novel non-antibody protein scaffold targeting CD40L | | Descriptor: | CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F. | | Deposit date: | 2017-11-30 | | Release date: | 2018-12-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Sci Transl Med, 11, 2019
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