PDB: 12119 resultsInfo pagesStatus searchChemie searchBIRD

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7ZQY	Chaetomium thermophilum Rad50 Zn hook Descriptor: DH domain-containing protein, ZINC ION Authors: Lammens, K, Rotheneder, M, Stakyte, K. Deposit date: 2022-05-03 Release date: 2022-12-28 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
7ZR1	Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure) Descriptor: DH domain-containing protein, Double-strand break repair protein, FHA domain-containing protein, ... Authors: Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. Deposit date: 2022-05-03 Release date: 2023-01-11 Last modified: 2023-12-13 Method: ELECTRON MICROSCOPY (4 Å) Cite: Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
7YXA	XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... Authors: Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. Deposit date: 2022-02-15 Release date: 2022-08-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors. Nat Commun, 13, 2022
7AI0	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.559 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
7AKH	Structure of DYRK2 in complex with compound 58 Descriptor: 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2 Authors: Dokurno, P, Surgenor, A.E, Kotschy, A. Deposit date: 2020-10-01 Release date: 2021-05-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J.Med.Chem., 64, 2021
7AKF	Structure of DYRK2 in complex with compound 50 Descriptor: 4-(2,3-dimethyl-1-benzofuran-5-yl)pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2 Authors: Dokurno, P, Surgenor, A.E, Kotschy, A. Deposit date: 2020-09-30 Release date: 2021-05-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J.Med.Chem., 64, 2021
7AI1	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
2TMK	YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP) Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, SULFATE ION, THYMIDYLATE KINASE Authors: Lavie, A, Schlichting, I. Deposit date: 1997-06-12 Release date: 1998-06-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nat.Struct.Biol., 4, 1997
2XKH	Xe derivative of C.lacteus mini-Hb Leu86Ala mutant Descriptor: NEURAL HEMOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Pesce, A, Nardini, M, Dewilde, S, Capece, L, Marti, M.A, Congia, S, Salter, M.D, Blouin, G.C, Estrin, D.A, Ascenzi, P, Moens, L, Bolognesi, M, Olson, J.S. Deposit date: 2010-07-08 Release date: 2010-12-08 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Ligand Migration in the Apolar Tunnel of Cerebratulus Lacteus Mini-Hemoglobin. J.Biol.Chem., 286, 2011
2XKI	Aquo-met structure of C.lacteus mini-Hb Descriptor: GLYCEROL, NEURAL HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Pesce, A, Nardini, M, Dewilde, S, Capece, L, Marti, M.A, Congia, S, Salter, M.D, Blouin, G.C, Estrin, D.A, Ascenzi, P, Moens, L, Bolognesi, M, Olson, J.S. Deposit date: 2010-07-08 Release date: 2010-12-08 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Ligand Migration in the Apolar Tunnel of Cerebratulus Lacteus Mini-Hemoglobin. J.Biol.Chem., 286, 2011
2XKG	C.lacteus mini-Hb Leu86Ala mutant Descriptor: NEURAL HEMOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Pesce, A, Nardini, M, Dewilde, S, Capece, L, Marti, M.A, Congia, S, Salter, M.D, Blouin, G.C, Estrin, D.A, Ascenzi, P, Moens, L, Bolognesi, M, Olson, J.S. Deposit date: 2010-07-08 Release date: 2010-12-08 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Ligand Migration in the Apolar Tunnel of Cerebratulus Lacteus Mini-Hemoglobin. J.Biol.Chem., 286, 2011
2W0J	Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor Descriptor: 4,4'-DIACETYLDIPHENYLUREA-BIS(GUANYLHYDRAZONE), NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 Authors: Lountos, G.T, Tropea, J.E, Zhang, D, Jobson, A.G, Pommier, Y, Shoemaker, R.H, Waugh, D.S. Deposit date: 2008-08-18 Release date: 2009-02-10 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of Checkpoint Kinase 2 in Complex with Nsc 109555, a Potent and Selective Inhibitor Protein Sci., 18, 2009
2Z5S	Molecular basis for the inhibition of p53 by Mdmx Descriptor: Cellular tumor antigen p53, Mdm4 protein Authors: Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. Deposit date: 2007-07-17 Release date: 2007-11-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
2Z5T	Molecular basis for the inhibition of p53 by Mdmx Descriptor: Cellular tumor antigen p53, Mdm4 protein Authors: Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. Deposit date: 2007-07-17 Release date: 2007-11-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
3BUA	Crystal Structure of TRF2 TRFH domain and APOLLO peptide complex Descriptor: DNA cross-link repair 1B protein, Telomeric repeat-binding factor 2 Authors: Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. Deposit date: 2008-01-02 Release date: 2008-02-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
3BQO	Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex Descriptor: TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 1 Authors: Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. Deposit date: 2007-12-20 Release date: 2008-02-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
3BRT	NEMO/IKK association domain structure Descriptor: Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha, NF-kappa-B essential modulator Authors: Silvian, L.F. Deposit date: 2007-12-21 Release date: 2008-04-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site. Structure, 16, 2008
4HFZ	Crystal Structure of an MDM2/P53 Peptide Complex Descriptor: Cellular tumor antigen p53, E3 ubiquitin-protein ligase Mdm2, SULFATE ION Authors: Anil, B, Riedinger, C, Endicott, J.A, Noble, M.E.M. Deposit date: 2012-10-05 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.694 Å) Cite: The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant. Acta Crystallogr.,Sect.D, 69, 2013
4IFI	Structure of human BRCA1 BRCT in complex with BAAT peptide Descriptor: ACETATE ION, BAAT peptide, Breast cancer type 1 susceptibility protein Authors: Liu, X, Ladias, J.A.A. Deposit date: 2012-12-14 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1. Biochemistry, 52, 2013
3BU8	Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex Descriptor: TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2 Authors: Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. Deposit date: 2008-01-02 Release date: 2008-02-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
3BRV	NEMO/IKKb association domain structure Descriptor: Inhibitor of nuclear factor kappa-B kinase subunit beta, NF-kappa-B essential modulator Authors: Silvian, L.F. Deposit date: 2007-12-21 Release date: 2008-04-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site. Structure, 16, 2008
1XU6	Structure of the C-terminal domain from Trypanosoma brucei Variant Surface Glycoprotein MITat1.2 Descriptor: Variant surface glycoprotein MITAT 1.2 Authors: Chattopadhyay, A, Jones, N.G, Nietlispach, D, Nielsen, P.R, Voorheis, H.P, Mott, H.R, Carrington, M. Deposit date: 2004-10-25 Release date: 2004-11-30 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2 J.Biol.Chem., 280, 2004
1NP9	Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat Descriptor: 5'-D(*TP*TP*AP*GP*GP*GP*T)-3' Authors: Gavathiotis, E, Searle, M.S. Deposit date: 2003-01-17 Release date: 2003-09-16 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations. ORG.BIOMOL.CHEM., 1, 2003
1PBZ	DE NOVO DESIGNED PEPTIDE-METALLOPORPHYRIN COMPLEX, SOLUTION STRUCTURE Descriptor: COPROPORPHYRIN I CONTAINING CO(III), De novo designed cyclic peptide Authors: Wang, J, Rosenblatt, M.M, Suslick, K.S. Deposit date: 2003-05-15 Release date: 2003-12-09 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: De novo designed cyclic-peptide heme complexes Proc.Natl.Acad.Sci.USA, 100, 2003
1MK6	SOLUTION STRUCTURE OF THE 8,9-DIHYDRO-8-(N7-GUANYL)-9-HYDROXY-AFLATOXIN B1 ADDUCT MISPAIRED WITH DEOXYADENOSINE Descriptor: 5'-D(*AP*CP*AP*TP*CP*GP*AP*TP*CP*T)-3', 5'-D(*AP*GP*AP*TP*AP*GP*AP*TP*GP*T)-3', 8,9-DIHYDRO-9-HYDROXY-AFLATOXIN B1 Authors: Giri, I, Johnston, D.S, Stone, M.P. Deposit date: 2002-08-28 Release date: 2002-10-16 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: MISPAIRING OF THE 8,9-DIHYDRO-8-(N7-GUANYL)-9-HYDROXY-AFLATOXIN B1 ADDUCT WITH DEOXYADENOSINE RESULTS IN EXTRUSION OF THE MISMATCHED DA TOWARD THE MAJOR GROOVE Biochemistry, 41, 2002

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