4HFZ

Crystal Structure of an MDM2/P53 Peptide Complex

Summary for 4HFZ

• Entry DOI: 10.2210/pdb4hfz/pdb
• Related: 4HG7
• Descriptor: E3 ubiquitin-protein ligase Mdm2, Cellular tumor antigen p53, SULFATE ION, ... (4 entities in total)
• Functional Keywords: mdm2, p53, surface entropy reduction, mutant validation, ligase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus, nucleoplasm: Q00987; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 4
• Total formula weight: 28550.43

Authors

Anil, B.,Riedinger, C.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2012-10-05, release date: 2013-07-31, Last modification date: 2024-02-28)

• Primary citation: Anil, B.,Riedinger, C.,Endicott, J.A.,Noble, M.E.; The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant.; Acta Crystallogr.,Sect.D, 69:1358-1366, 2013; PubMed: 23897459; DOI: 10.1107/S0907444913004459

Experimental method

X-RAY DIFFRACTION (2.694 Å)