4HFZ
Crystal Structure of an MDM2/P53 Peptide Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | E3 ubiquitin-protein ligase Mdm2 | polymer | 109 | 12419.2 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | B, D (B, D) | Cellular tumor antigen p53 | polymer | 15 | 1808.0 | 2 | UniProt (P04637) Pfam (PF08563) | Homo sapiens | Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
| 3 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G, H (A, B, C) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, C: 17 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Ala 69 | Glu 69 | engineered mutation |
| Ala 70 | Lys 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 28454.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 28550.4 |
