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7ZNR
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BU of 7znr by Molmil
Inactive D62N mutant of BT1760 Endo-acting levanase from Bacteroides thetaiotaomicron VPI-5482
Descriptor: SULFATE ION, Sucrose-6-phosphate hydrolase, beta-D-fructofuranose-(2-6)-beta-D-fructofuranose, ...
Authors:Basle, A, Bolam, D.
Deposit date:2022-04-21
Release date:2023-06-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes.
Nature, 618, 2023
6YKN
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BU of 6ykn by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11b
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6IZ1
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BU of 6iz1 by Molmil
Crystal Structure Analysis of a Eukaryotic Membrane Protein
Descriptor: CALCIUM ION, CHLORIDE ION, Trimeric intracellular cation channel type A
Authors:Wang, X.H, Zeng, Y, Gao, F, Su, M, Chen, Y.H.
Deposit date:2018-12-18
Release date:2019-05-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:Structural basis for activity of TRIC counter-ion channels in calcium release.
Proc.Natl.Acad.Sci.USA, 116, 2019
7KG8
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BU of 7kg8 by Molmil
Structure of human PARG complexed with PARG-061
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-6-sulfanylidene-1,3,6,7-tetrahydro-2H-purin-2-one, CACODYLATE ION, DIMETHYL SULFOXIDE, ...
Authors:Brosey, C.A, Balapiti-Modarage, L.P.F, Warden, L.S, Jones, D.E, Ahmed, Z, Tainer, J.A.
Deposit date:2020-10-16
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Prog.Biophys.Mol.Biol., 163, 2021
8SC8
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BU of 8sc8 by Molmil
Structure of PI3KG in complex with MTX-531
Descriptor: N-[(5P)-2-chloro-5-(4-{[(1R)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:Whitehead, C.E, Leopold, J.
Deposit date:2023-04-05
Release date:2024-06-12
Method:X-RAY DIFFRACTION (2.687 Å)
Cite:Structure of PI3KG in complex with MTX-531
To Be Published
5UP8
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BU of 5up8 by Molmil
Crystal Structure of the Zn-bound Human Heavy-Chain variant 122H-delta C-star with para-benzenedihydroxamate
Descriptor: Ferritin heavy chain, N,N'-dihydroxybenzene-1,4-dicarboxamide, SODIUM ION, ...
Authors:Bailey, J.B, Zhang, L, Chiong, J.C, Ahn, S, Tezcan, F.A.
Deposit date:2017-02-01
Release date:2017-06-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Synthetic Modularity of Protein-Metal-Organic Frameworks.
J. Am. Chem. Soc., 139, 2017
7ZNS
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BU of 7zns by Molmil
Inactive D62N mutant of BT1760 Endo-acting levanase from Bacteroides thetaiotaomicron VPI-5482
Descriptor: Glycoside hydrolase family 32, SULFATE ION, beta-D-fructofuranose-(2-6)-beta-D-fructofuranose, ...
Authors:Basle, A, Bolam, D.
Deposit date:2022-04-21
Release date:2023-06-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes.
Nature, 618, 2023
6YKW
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BU of 6ykw by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11h
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6POB
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BU of 6pob by Molmil
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-(3-(Aminomethyl)-4-(thiazol-4-ylmethoxy)phenyl)-4-methylquinolin-2-amine
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-{3-(aminomethyl)-4-[(1,3-thiazol-4-yl)methoxy]phenyl}-4-methylquinolin-2-amine, GLYCEROL, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2019-07-03
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
7PVZ
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BU of 7pvz by Molmil
Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant
Descriptor: Isoform 2 of Proto-oncogene tyrosine-protein kinase Src
Authors:Camara-Artigas, A, Salinas Garcia, M.C.
Deposit date:2021-10-05
Release date:2022-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The effect of the hinge loops composition in the domain swapping of the SH3 domain
To be published
8A8L
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BU of 8a8l by Molmil
Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with a heme-coordinated fragment
Descriptor: 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, Cytochrome P450 protein, GLYCEROL, ...
Authors:Snee, M, Katariya, M, Levy, C.
Deposit date:2022-06-23
Release date:2023-07-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with a heme-coordinated fragment
To Be Published
8RPJ
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BU of 8rpj by Molmil
JanthE from Janthinobacterium sp. HH01
Descriptor: ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Lanza, L, Leogrande, C, Rabe von Pappenheim, F, Tittmann, K, Mueller, M.
Deposit date:2024-01-16
Release date:2024-06-12
Last modified:2024-08-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif.
Angew.Chem.Int.Ed.Engl., 63, 2024
5UPH
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BU of 5uph by Molmil
Lipids bound lysosomal integral membrane protein 2
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Conrad, K.S, Liu, S.
Deposit date:2017-02-03
Release date:2017-12-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Nat Commun, 8, 2017
7L6W
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BU of 7l6w by Molmil
SFX structure of the MyD88 TIR domain higher-order assembly
Descriptor: Myeloid differentiation primary response protein MyD88
Authors:Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Flueckiger, L, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Stacey, K.J, Darmanin, C, Kobe, B, Xu, H, Ve, T.
Deposit date:2020-12-24
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
7PVO
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BU of 7pvo by Molmil
Adenylosuccinate Synthetase from H. pylori in complex with IMP
Descriptor: Adenylosuccinate synthetase, INOSINIC ACID, SULFATE ION
Authors:Narczyk, M, Bzowska, A, Maksymiuk, W.
Deposit date:2021-10-05
Release date:2022-11-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site.
Int.J.Biol.Macromol., 226, 2023
6BHG
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BU of 6bhg by Molmil
Crystal structure of SETDB1 with a modified H3 peptide
Descriptor: Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2017-10-30
Release date:2017-12-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
8RPI
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BU of 8rpi by Molmil
JanthE from Janthinobacterium sp. HH01, lactyl-ThDP
Descriptor: 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-CARBOXY-1-HYDROXYETHYL)-5-(2-{[HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Lanza, L, Leogrande, C, Rabe von Pappenheim, F, Tittmann, K, Mueller, M.
Deposit date:2024-01-16
Release date:2024-06-12
Last modified:2024-08-21
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif.
Angew.Chem.Int.Ed.Engl., 63, 2024
8RPH
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BU of 8rph by Molmil
JanthE from Janthinobacterium sp. HH01,ketobutyryl-ThDP
Descriptor: (2~{S})-2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-2-yl]-2-oxidanyl-butanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Lanza, L, Leogrande, C, Rabe von Pappenheim, F, Tittmann, K, Mueller, M.
Deposit date:2024-01-16
Release date:2024-06-12
Last modified:2024-08-21
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif.
Angew.Chem.Int.Ed.Engl., 63, 2024
6POU
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BU of 6pou by Molmil
Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(4-(2-Aminoethyl)phenyl)-4-methylquinolin-2-amine
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 7-[4-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine, GADOLINIUM ATOM, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2019-07-05
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
6J98
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BU of 6j98 by Molmil
Crystal structure of P8 from Lactobacillus rhamnosus
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, P8, ...
Authors:Cha, Y.J, Cho, H.S.
Deposit date:2019-01-22
Release date:2020-03-04
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of P8 from Lactobacillus rhamnosus
To Be Published
8A4D
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BU of 8a4d by Molmil
1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa with a thiamine analog inhibitor
Descriptor: 1-deoxy-D-xylulose-5-phosphate synthase, 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]phenyl}ethanol, CALCIUM ION, ...
Authors:Hamid, R, Hirsch, A.
Deposit date:2022-06-10
Release date:2023-07-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding.
J.Biol.Chem., 299, 2023
5V4G
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BU of 5v4g by Molmil
Ruthenium(II)(cymene)(chlorido)2-lysozyme adduct with two binding sites
Descriptor: Lysozyme C, PARA-CYMENE RUTHENIUM CHLORIDE, SODIUM ION
Authors:Sullivan, M.P, Hartinger, C.G, Goldstone, D.C.
Deposit date:2017-03-09
Release date:2017-04-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography.
Chem. Commun. (Camb.), 53, 2017
7Q4N
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BU of 7q4n by Molmil
transcription factor CDX2 bound to hydroxymethylated DNA
Descriptor: DNA (18-MER), Homeobox protein CDX-2
Authors:Morgunova, E, Yin, Y, Popov, A, Taipale, J.
Deposit date:2021-11-01
Release date:2022-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:transcription factor CDX2 bound to hydroxymethylated DNA
To Be Published
6YKX
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BU of 6ykx by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11j
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6BIL
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BU of 6bil by Molmil
HLA-DRB1 in complex with citrullinated fibrinogen peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 74cit69-81, HLA class II histocompatibility antigen, ...
Authors:Ting, Y.T, Scally, S.W, Rossjohn, J.
Deposit date:2017-11-02
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
J. Biol. Chem., 293, 2018

224201

数据于2024-08-28公开中

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