8SC8

Structure of PI3KG in complex with MTX-531

Summary for 8SC8

• Entry DOI: 10.2210/pdb8sc8/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-[(5P)-2-chloro-5-(4-{[(1R)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide, ... (4 entities in total)
• Functional Keywords: pi3kg, dual egfr/pi3k inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 111661.36

Authors

Whitehead, C.E.,Leopold, J. (deposition date: 2023-04-05, release date: 2024-06-12)

• Primary citation: Whitehead, C.E.,Leopold, J.; Structure of PI3KG in complex with MTX-531; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.687 Å)