8IUL
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![BU of 8iul by Molmil](/molmil-images/mine/8iul) | Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex | Descriptor: | Antibody fragment scFv16, G subunit alpha (q), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wu, C, Xu, Y, Xu, H.E. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor. Nat Commun, 14, 2023
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8IUF
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![BU of 8iuf by Molmil](/molmil-images/mine/8iuf) | Cryo-EM structure of Euglena gracilis super-complex I+III2+IV, composite | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | Deposit date: | 2023-03-24 | Release date: | 2024-02-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8IUJ
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![BU of 8iuj by Molmil](/molmil-images/mine/8iuj) | Cryo-EM structure of Euglena gracilis super-complex III2+IV2, composite | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | Deposit date: | 2023-03-24 | Release date: | 2024-02-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8GMC
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![BU of 8gmc by Molmil](/molmil-images/mine/8gmc) | CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 COMPLEXED WITH 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | Descriptor: | 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine, AP2-associated protein kinase 1, SULFATE ION | Authors: | Muckelbauer, J.K. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain. Med.Chem.Res., 2023
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8GMD
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![BU of 8gmd by Molmil](/molmil-images/mine/8gmd) | CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 COMPLEXED WITH (5P)-3-({(8R)-5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-[2-(propan-2-yl)-2H-tetrazol-5-yl]phenol | Descriptor: | (5P)-3-({(8R)-5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-[2-(propan-2-yl)-2H-tetrazol-5-yl]phenol, AP2-associated protein kinase 1, SULFATE ION | Authors: | Muckelbauer, J.K. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain. Med.Chem.Res., 2023
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8OIY
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![BU of 8oiy by Molmil](/molmil-images/mine/8oiy) | |
8GLZ
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![BU of 8glz by Molmil](/molmil-images/mine/8glz) | Crystal structure of T252E-CYP199A4 in complex with 4-hydroxybenzoic acid. Crystal was initially co-crystallised with 4-methoxybenzoic acid and soaked with 4 mM hydrogen peroxide | Descriptor: | CHLORIDE ION, Cytochrome P450, P-HYDROXYBENZOIC ACID, ... | Authors: | Lee, J.H.Z, Bruning, J.B, Bell, S.G. | Deposit date: | 2023-03-23 | Release date: | 2023-12-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase. Chemistry, 30, 2024
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8GLY
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![BU of 8gly by Molmil](/molmil-images/mine/8gly) | Crystal structure of T252E-CYP199A4 in complex with 4-hydroxybenzoic acid | Descriptor: | CHLORIDE ION, Cytochrome P450, P-HYDROXYBENZOIC ACID, ... | Authors: | Lee, J.H.Z, Bruning, J.B, Bell, S.G. | Deposit date: | 2023-03-23 | Release date: | 2024-02-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase. Chemistry, 30, 2024
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8OIL
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![BU of 8oil by Molmil](/molmil-images/mine/8oil) | |
8GLS
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![BU of 8gls by Molmil](/molmil-images/mine/8gls) | |
8GLV
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![BU of 8glv by Molmil](/molmil-images/mine/8glv) | |
8IU2
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![BU of 8iu2 by Molmil](/molmil-images/mine/8iu2) | Cryo-EM structure of Long-wave-sensitive opsin 1 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Peng, Q, Cheng, X.Y, Li, J, Lu, Q.Y, Li, Y.Y, Zhang, J. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cryo-EM structure of Long-wave-sensitive opsin 1 To Be Published
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8ITV
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![BU of 8itv by Molmil](/molmil-images/mine/8itv) | KL2.1 in complex with CRM1-Ran-RanBP1 | Descriptor: | (3~{S},5~{R},6~{E},8~{Z},10~{R},12~{E},14~{E},16~{S})-3,16-bis(azanyl)-8,10,12-trimethyl-16-[(2~{S},4~{R},5~{S},6~{S})-5-methyl-4-oxidanyl-6-[(~{E})-prop-1-enyl]oxan-2-yl]-5-oxidanyl-hexadeca-6,8,12,14-tetraenoic acid, ACETATE ION, CHLORIDE ION, ... | Authors: | Sun, Q, Jian, L. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | KL2.1 in complex with CRM1-Ran-RanBP1 To Be Published
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8OI6
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![BU of 8oi6 by Molmil](/molmil-images/mine/8oi6) | Cryo-EM structure of the undecorated barbed end of filamentous beta/gamma actin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. | Deposit date: | 2023-03-22 | Release date: | 2023-08-09 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
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8OI8
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![BU of 8oi8 by Molmil](/molmil-images/mine/8oi8) | Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the R183W mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. | Deposit date: | 2023-03-22 | Release date: | 2023-08-16 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.28 Å) | Cite: | Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
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8ITF
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![BU of 8itf by Molmil](/molmil-images/mine/8itf) | Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | Deposit date: | 2023-03-22 | Release date: | 2023-05-31 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8ITM
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![BU of 8itm by Molmil](/molmil-images/mine/8itm) | Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein | Descriptor: | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, F.H, Hang, K.N, Zhou, Q.T, Shao, L.J, Li, H, Li, W.Z, Lin, S, Dai, A.T, Cai, X.Q, Liu, Y.Y, Xu, Y.N, Feng, W.B, Yang, D.H, Wang, M.W. | Deposit date: | 2023-03-22 | Release date: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Molecular basis of signal transduction mediated by the human GIPR splice variants. Proc.Natl.Acad.Sci.USA, 120, 2023
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8ITL
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![BU of 8itl by Molmil](/molmil-images/mine/8itl) | Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein | Descriptor: | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, F.H, Hang, K.N, Zhou, Q.T, Shao, L.J, Li, H, Li, W.Z, Lin, S, Dai, A.T, Cai, X.Q, Liu, Y.Y, Xu, Y.N, Feng, W.B, Yang, D.H, Wang, M.W. | Deposit date: | 2023-03-22 | Release date: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Molecular basis of signal transduction mediated by the human GIPR splice variants. Proc.Natl.Acad.Sci.USA, 120, 2023
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8OID
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![BU of 8oid by Molmil](/molmil-images/mine/8oid) | Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the N111S mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. | Deposit date: | 2023-03-22 | Release date: | 2023-08-09 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
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8OHA
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![BU of 8oha by Molmil](/molmil-images/mine/8oha) | Crystal structure of Leptospira interrogans GAPDH | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase, ... | Authors: | Navas-Yuste, S, de la Paz, K, Querol-Garcia, J, Gomez-Quevedo, S, Rodriguez de Cordoba, S, Fernandez, F.J, Vega, M.C. | Deposit date: | 2023-03-20 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | The structure of Leptospira interrogans GAPDH sheds light into an immunoevasion factor that can target the anaphylatoxin C5a of innate immunity. Front Immunol, 14, 2023
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8OH9
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![BU of 8oh9 by Molmil](/molmil-images/mine/8oh9) | Cryo-EM structure of the electron bifurcating transhydrogenase StnABC complex from Sporomusa Ovata (state 1) | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Formate dehydrogenase-O, ... | Authors: | Kumar, A, Kremp, F, Mueller, V, Schuller, J.M. | Deposit date: | 2023-03-20 | Release date: | 2023-09-13 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular architecture and electron transfer pathway of the Stn family transhydrogenase. Nat Commun, 14, 2023
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8OH5
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![BU of 8oh5 by Molmil](/molmil-images/mine/8oh5) | Cryo-EM structure of the electron bifurcating transhydrogenase StnABC complex from Sporomusa Ovata (state 2) | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Kumar, A, Kremp, F, Mueller, V, Schuller, J.M. | Deposit date: | 2023-03-20 | Release date: | 2023-09-13 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular architecture and electron transfer pathway of the Stn family transhydrogenase. Nat Commun, 14, 2023
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8GKO
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![BU of 8gko by Molmil](/molmil-images/mine/8gko) | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | Descriptor: | 1,2-ETHANEDIOL, Alkaline protease 1, FORMYL GROUP, ... | Authors: | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | Deposit date: | 2023-03-20 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
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8GKQ
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![BU of 8gkq by Molmil](/molmil-images/mine/8gkq) | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | Descriptor: | 1,2-ETHANEDIOL, Alkaline protease 1, CALCIUM ION, ... | Authors: | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | Deposit date: | 2023-03-20 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
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8GKP
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![BU of 8gkp by Molmil](/molmil-images/mine/8gkp) | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | Descriptor: | Alkaline protease 1, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... | Authors: | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | Deposit date: | 2023-03-20 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
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