4XH8
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7T9O
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![BU of 7t9o by Molmil](/molmil-images/mine/7t9o) | HIV Integrase in complex with Compound-25 | Descriptor: | (2S)-tert-butoxy[4-(4,4-dimethylpiperidin-1-yl)-5-{4-[2-(4-fluorophenyl)ethoxy]phenyl}-2,6-dimethylpyridin-3-yl]acetic acid, GLYCEROL, Integrase, ... | Authors: | Khan, J.A, Lewis, H, Kish, K. | Deposit date: | 2021-12-19 | Release date: | 2022-04-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs. J.Med.Chem., 65, 2022
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7N4P
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![BU of 7n4p by Molmil](/molmil-images/mine/7n4p) | Crystal Structure of Lizard Cadherin-23 EC1-2 | Descriptor: | CALCIUM ION, Cadherin 23, SODIUM ION | Authors: | Nisler, C.R, Sotomayor, M. | Deposit date: | 2021-06-04 | Release date: | 2022-06-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.097 Å) | Cite: | Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation. Mol.Biol.Evol., 40, 2023
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4QAT
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![BU of 4qat by Molmil](/molmil-images/mine/4qat) | 1.75 A resolution structure of CT263-D161N (MTAN) from Chlamydia trachomatis bound to MTA | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, CT263 | Authors: | Barta, M.L, Thomas, K, Lovell, S, Battaile, K.P, Schramm, V.L, Hefty, P.S. | Deposit date: | 2014-05-05 | Release date: | 2014-10-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural and Biochemical Characterization of Chlamydia trachomatis Hypothetical Protein CT263 Supports That Menaquinone Synthesis Occurs through the Futalosine Pathway. J.Biol.Chem., 289, 2014
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8DJM
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![BU of 8djm by Molmil](/molmil-images/mine/8djm) | HMGCR-UBIAD1 Complex State 1 | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, CHOLESTEROL HEMISUCCINATE, Digitonin, ... | Authors: | Chen, H, Qi, X, Li, X. | Deposit date: | 2022-07-01 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nat Commun, 13, 2022
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4QBN
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![BU of 4qbn by Molmil](/molmil-images/mine/4qbn) | VRR_NUC domain | Descriptor: | Nuclease, SULFATE ION | Authors: | Smerdon, S.J, Pennell, S, Li, J. | Deposit date: | 2014-05-08 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Cell Rep, 8, 2014
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6Y1A
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![BU of 6y1a by Molmil](/molmil-images/mine/6y1a) | Amyloid fibril structure of islet amyloid polypeptide | Descriptor: | AMINO GROUP, Islet amyloid polypeptide | Authors: | Roeder, C, Kupreichyk, T, Gremer, L, Schaefer, L.U, Pothula, K.R, Ravelli, R.B.G, Willbold, D, Hoyer, W, Schroder, G.F. | Deposit date: | 2020-02-11 | Release date: | 2020-03-04 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils. Nat.Struct.Mol.Biol., 27, 2020
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8DJK
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![BU of 8djk by Molmil](/molmil-images/mine/8djk) | HMGCR-UBIAD1 Complex State 2 | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, CHOLESTEROL HEMISUCCINATE, Digitonin, ... | Authors: | Chen, H, Qi, X, Li, X. | Deposit date: | 2022-06-30 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nat Commun, 13, 2022
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7PV0
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![BU of 7pv0 by Molmil](/molmil-images/mine/7pv0) | Crystal structure of a Mic60-Mic19 fusion protein | Descriptor: | MICOS complex subunit MIC60,MICOS complex subunit MIC60-MIC19,Mic60-Mic19, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) | Authors: | Funck, K, Bock-Bierbaum, T, Daumke, O. | Deposit date: | 2021-10-01 | Release date: | 2022-09-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural insights into crista junction formation by the Mic60-Mic19 complex. Sci Adv, 8, 2022
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8DAX
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![BU of 8dax by Molmil](/molmil-images/mine/8dax) | New insights into the P186 flip and oligomeric state of Staphylococcus aureus exfoliative toxin E: implications for the exfoliative mechanism | Descriptor: | Exfoliative toxin E | Authors: | Gismene, C, Nascimento, A.F.Z, Hernandez-Gonzalez, J.E, Santisteban, A.R.N, de Moraes, F.R, Arni, R.K, Mariutti, R.B. | Deposit date: | 2022-06-14 | Release date: | 2022-11-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Staphylococcus aureus Exfoliative Toxin E, Oligomeric State and Flip of P186: Implications for Its Action Mechanism. Int J Mol Sci, 23, 2022
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7T38
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4QFB
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![BU of 4qfb by Molmil](/molmil-images/mine/4qfb) | 1.99 A resolution structure of SeMet-CT263 (MTAN) from Chlamydia trachomatis | Descriptor: | CT263 | Authors: | Barta, M.L, Thomas, K, Lovell, S, Battaile, K.P, Schramm, V.L, Hefty, P.S. | Deposit date: | 2014-05-20 | Release date: | 2014-10-01 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.986 Å) | Cite: | Structural and Biochemical Characterization of Chlamydia trachomatis Hypothetical Protein CT263 Supports That Menaquinone Synthesis Occurs through the Futalosine Pathway. J.Biol.Chem., 289, 2014
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7T37
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![BU of 7t37 by Molmil](/molmil-images/mine/7t37) | Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2, cannabidiol | Authors: | Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. | Deposit date: | 2021-12-07 | Release date: | 2022-05-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into TRPV2 activation by small molecules. Nat Commun, 13, 2022
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3O8Z
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![BU of 3o8z by Molmil](/molmil-images/mine/3o8z) | Crystal structure of Spn1 (Iws1) core domain | Descriptor: | SULFATE ION, Transcription factor IWS1 | Authors: | McDonald, S.M, Close, D, Hill, C.P. | Deposit date: | 2010-08-03 | Release date: | 2010-11-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure and biological importance of the spn1-spt6 interaction, and its regulatory role in nucleosome binding. Mol.Cell, 40, 2010
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7NR1
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![BU of 7nr1 by Molmil](/molmil-images/mine/7nr1) | Crystal structure of holo-S116A mutant of Hydroxy ketone aldolase (SwHKA) from Sphingomonas wittichii RW1 | Descriptor: | HpcH/HpaI aldolase, MAGNESIUM ION | Authors: | Justo, I, Marsden, S.R, Hanefeld, U, Bento, I. | Deposit date: | 2021-03-02 | Release date: | 2022-09-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Substrate Induced Movement of the Metal Cofactor between Active and Resting State. Angew.Chem.Int.Ed.Engl., 61, 2022
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6YKR
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6YL5
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![BU of 6yl5 by Molmil](/molmil-images/mine/6yl5) | Crystal structure of the SAM-SAH riboswitch with SAH | Descriptor: | Chains: A,B,C,D,E,F,G,H,I,J,K,L, MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Huang, L, Lilley, D.M.J. | Deposit date: | 2020-04-06 | Release date: | 2020-07-22 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure and ligand-induced folding of the SAM/SAH riboswitch. Nucleic Acids Res., 2020
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4XBF
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![BU of 4xbf by Molmil](/molmil-images/mine/4xbf) | Structure of LSD1:CoREST in complex with ssRNA | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | Authors: | Luka, Z, Loukachevitch, L.V, Martin, W.J, Wagner, C, Reiter, N.J. | Deposit date: | 2014-12-16 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme. RNA, 22, 2016
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6YMI
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![BU of 6ymi by Molmil](/molmil-images/mine/6ymi) | Crystal structure of the SAM-SAH riboswitch with AMP. | Descriptor: | 5-BROMOCYTIDINE 5'-(DIHYDROGEN PHOSPHATE), ADENOSINE MONOPHOSPHATE, Chains: A,C,F,I,M,O, ... | Authors: | Huang, L, Lilley, D.M.J. | Deposit date: | 2020-04-08 | Release date: | 2020-07-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure and ligand-induced folding of the SAM/SAH riboswitch. Nucleic Acids Res., 48, 2020
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7ST8
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![BU of 7st8 by Molmil](/molmil-images/mine/7st8) | Crystal structure of 7H2.2 Fab in complex with SAS1B C-terminal region | Descriptor: | 7H2.2 Fab Heavy Chain, 7H2.2 Fab Light Chain, Astacin-like metalloendopeptidase | Authors: | Legg, M.S.G, Evans, S.V. | Deposit date: | 2021-11-12 | Release date: | 2022-05-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Monoclonal antibody 7H2.2 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered Acta Crystallogr.,Sect.D, 78, 2022
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6P0B
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![BU of 6p0b by Molmil](/molmil-images/mine/6p0b) | Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ | Descriptor: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | Authors: | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | Deposit date: | 2019-05-16 | Release date: | 2019-12-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.203 Å) | Cite: | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
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4PW3
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6YOX
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7POO
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![BU of 7poo by Molmil](/molmil-images/mine/7poo) | Crystal structure of profragilysin-3 (proBFT-3) from Bacteroides fragilis in complex with foliosidine in P212121. | Descriptor: | ACETATE ION, BFT-3, PROLINE, ... | Authors: | Eckhard, U, Guevara, T, Gomis-Ruth, F.X. | Deposit date: | 2021-09-09 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis. Protein Sci., 31, 2022
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8JHO
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