7ST8

Crystal structure of 7H2.2 Fab in complex with SAS1B C-terminal region

Summary for 7ST8

• Entry DOI: 10.2210/pdb7st8/pdb
• Descriptor: 7H2.2 Fab Heavy Chain, 7H2.2 Fab Light Chain, Astacin-like metalloendopeptidase, ... (4 entities in total)
• Functional Keywords: cancer, antibody, oocyte antigen, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 3
• Total formula weight: 64900.09

Authors

Legg, M.S.G.,Evans, S.V. (deposition date: 2021-11-12, release date: 2022-05-11, Last modification date: 2023-10-18)

• Primary citation: Legg, M.S.G.,Gagnon, S.M.L.,Powell, C.J.,Boulanger, M.J.,Li, A.J.J.,Evans, S.V.; Monoclonal antibody 7H2.2 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered; Acta Crystallogr.,Sect.D, 78:623-632, 2022; PubMed: 35503210; DOI: 10.1107/S2059798322003011

Experimental method