PDB: 5591 resultsInfo pagesStatus searchChemie searchBIRD

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5K2G	Structure of GNNQQNY from yeast prion Sup35 in space group P21 determined by MicroED Descriptor: Eukaryotic peptide chain release factor GTP-binding subunit Authors: Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S. Deposit date: 2016-05-18 Release date: 2016-09-14 Last modified: 2024-03-06 Method: ELECTRON CRYSTALLOGRAPHY (1.1 Å) Cite: Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc.Natl.Acad.Sci.USA, 113, 2016
4E76	Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion Descriptor: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION Authors: Edwards, T.E, Mosley, R.T. Deposit date: 2012-03-16 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
4E78	Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG Descriptor: 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase) Authors: Edwards, T.E, Mosley, R.T. Deposit date: 2012-03-16 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
4H7Z	tRNA-guanine transglycosylase Y106F, C158V mutant in complex with guanine Descriptor: GLYCEROL, GUANINE, Queuine tRNA-ribosyltransferase, ... Authors: Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. Deposit date: 2012-09-21 Release date: 2012-10-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
4H6E	tRNA-guanine transglycosylase Y106F, C158V, V233G mutant apo structure Descriptor: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION Authors: Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. Deposit date: 2012-09-19 Release date: 2012-11-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
4E7A	Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-ddC Descriptor: 5'-R(*CP*AP*UP*GP*GP*C)-D(P*(DOC))-3', RNA-directed RNA polymerase Authors: Edwards, T.E, Mosley, R.T. Deposit date: 2012-03-16 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
4HSH	tRNA-guanine transglycosylase Y106F, V233G mutant in complex with queuine Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. Deposit date: 2012-10-30 Release date: 2012-11-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
4GD0	tRNA-guanine transglycosylase Y106F, C158V mutant Descriptor: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION Authors: Schmidt, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. Deposit date: 2012-07-31 Release date: 2012-08-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.29 Å) Cite: Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
4HVX	tRNA-guanine transglycosylase Y106F, C158V mutant in complex with queuine Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. Deposit date: 2012-11-07 Release date: 2012-12-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
4HQV	tRNA-guanine transglycosylase Y106F, C158V, V233G mutant in complex with queuine Descriptor: 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. Deposit date: 2012-10-26 Release date: 2012-11-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
3P96	Crystal structure of Phosphoserine phosphatase SerB from Mycobacterium avium, native form Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-10-15 Release date: 2010-11-10 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.05 Å) Cite: SAD phasing using iodide ions in a high-throughput structural genomics environment. J.Struct.Funct.Genom., 12, 2011
3QBH	Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors Descriptor: (4S)-4-(2-hydroxy-5-{[(3S,4S,5R)-4-hydroxy-1,1-dioxido-5-{[3-(propan-2-yl)benzyl]amino}tetrahydro-2H-thiopyran-3-yl]methyl}benzyl)-3-propyl-1,3-oxazolidin-2-one, Beta-secretase 1 Authors: Rondeau, J.M. Deposit date: 2011-01-13 Release date: 2011-03-23 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
3PM6	Crystal structure of a putative fructose-1,6-biphosphate aldolase from Coccidioides immitis solved by combined SAD MR Descriptor: IODIDE ION, Putative fructose-bisphosphate aldolase, ZINC ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-11-16 Release date: 2010-12-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: SAD phasing using iodide ions in a high-throughput structural genomics environment. J Struct Funct Genomics, 12, 2011
3OGZ	Protein structure of USP from L. major in Apo-form Descriptor: GLYCEROL, UDP-sugar pyrophosphorylase Authors: Dickmanns, A, Damerow, S, Neumann, P, Schulz, E.-C, Lamerz, A, Routier, F, Ficner, R. Deposit date: 2010-08-17 Release date: 2010-11-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major. J.Mol.Biol., 405, 2011
3OH0	Protein structure of USP from L. major bound to URIDINE-5'-TRIPHOSPHATE Descriptor: GLYCEROL, UDP-sugar pyrophosphorylase, URIDINE 5'-TRIPHOSPHATE Authors: Dickmanns, A, Damerow, S, Neumann, P, Schulz, E.-C, Lamerz, A, Routier, F, Ficner, R. Deposit date: 2010-08-17 Release date: 2010-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major. J.Mol.Biol., 405, 2011
3STX	Crystal Structure of tomato Methylketone Synthase I H243A variant complexed with beta-ketoheptanoate Descriptor: 3-oxoheptanoic acid, Methylketone synthase 1 Authors: Auldridge, M.E, Austin, M.B, Noel, J.P. Deposit date: 2011-07-11 Release date: 2012-05-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Emergent Decarboxylase Activity and Attenuation of alpha/beta-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in Tomato. Plant Cell, 24, 2012
3STV	Crystal Structure of tomato Methylketone Synthase I complexed with 3-hydroxyoctanoate Descriptor: (3S)-3-hydroxyoctanoic acid, BROMIDE ION, Methylketone synthase 1 Authors: Auldridge, M.E, Austin, M.B, Noel, J.P. Deposit date: 2011-07-11 Release date: 2012-05-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Emergent Decarboxylase Activity and Attenuation of alpha/beta-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in Tomato. Plant Cell, 24, 2012
3STW	Crystal Structure of tomato Methylketone Synthase I complexed with 2-tridecanone Descriptor: Methylketone synthase 1, tridec-12-en-2-one Authors: Auldridge, M.E, Austin, M.B, Noel, J.P. Deposit date: 2011-07-11 Release date: 2012-05-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Emergent Decarboxylase Activity and Attenuation of alpha/beta-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in Tomato. Plant Cell, 24, 2012
8B10	Crystal Structure of Shank2-SAM mutant domain - L1800W Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Bento, I, Gracia Alai, M, Kreienkamp, J.-H. Deposit date: 2022-09-08 Release date: 2022-11-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol Psychiatry, 2022
8ATJ	Crystal Structure of Shank2-SAM domain Descriptor: CHLORIDE ION, FORMIC ACID, Isoform 4 of SH3 and multiple ankyrin repeat domains protein 2, ... Authors: Bento, I, Gracia Alai, M, Kreienkamp, J.-H. Deposit date: 2022-08-23 Release date: 2022-11-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.117 Å) Cite: Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol Psychiatry, 2022
7ZU9	CRYSTAL STRUCTURE OF THE C89A_C113A GMP SYNTHETASE INACTIVE DOUBLE MUTANT FROM PLASMODIUM FALCIPARUM Descriptor: Glutamine amidotransferase Authors: Ballut, L, Violot, S, Aghajari, N. Deposit date: 2022-05-11 Release date: 2022-08-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis. Biomolecules, 12, 2022
6Y99	hSTING mutant R232K in complex with 2',3'-cGAMP Descriptor: Stimulator of interferon genes protein, cGAMP Authors: Boura, E, Smola, M. Deposit date: 2020-03-06 Release date: 2021-03-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.984 Å) Cite: Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
6YDZ	Human wtSTING in complex with 3',3'-cGAMP Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon protein Authors: Boura, E, Smola, M. Deposit date: 2020-03-23 Release date: 2021-03-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
6YEA	Human wtSTING in complex with 2',2'-difluoro-3',3'-cGAMP Descriptor: 2',2'-difluoro-3',3'-cGAMP, Stimulator of interferon protein Authors: Boura, E, Smola, M. Deposit date: 2020-03-24 Release date: 2021-03-31 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.805 Å) Cite: Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
6K61	Cryo-EM structure of the tetrameric photosystem I from a heterocyst-forming cyanobacterium Anabaena sp. PCC7120 Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... Authors: Zheng, L, Li, Y, Li, X, Zhong, Q, Li, N, Zhang, K, Zhang, Y, Chu, H, Ma, C, Li, G, Zhao, J, Gao, N. Deposit date: 2019-05-31 Release date: 2019-10-09 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.37 Å) Cite: Structural and functional insights into the tetrameric photosystem I from heterocyst-forming cyanobacteria. Nat.Plants, 5, 2019

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