8B10

Crystal Structure of Shank2-SAM mutant domain - L1800W

Summary for 8B10

• Entry DOI: 10.2210/pdb8b10/pdb
• Descriptor: SH3 and multiple ankyrin repeat domains protein 2, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: synaptic scaffold protein; zn2+ binding; zn-dependent polymerization;, metal binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 49491.84

Authors

Bento, I.,Gracia Alai, M.,Kreienkamp, J.-H. (deposition date: 2022-09-08, release date: 2022-11-30, Last modification date: 2024-01-31)

• Primary citation: Hassani Nia, F.,Woike, D.,Bento, I.,Niebling, S.,Tibbe, D.,Schulz, K.,Hirnet, D.,Skiba, M.,Honck, H.H.,Veith, K.,Gunther, C.,Scholz, T.,Bierhals, T.,Driemeyer, J.,Bend, R.,Failla, A.V.,Lohr, C.,Alai, M.G.,Kreienkamp, H.J.; Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans.; Mol Psychiatry, 2022; PubMed: 36450866; DOI: 10.1038/s41380-022-01882-3

Experimental method

X-RAY DIFFRACTION (1.95 Å)