1HAK
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![BU of 1hak by Molmil](/molmil-images/mine/1hak) | CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR | Descriptor: | 4-[3-{1-(4-BENZYL)PIPERODINYL}PROPIONYL]-7-METHOXY-2,3,4,5-TERTRAHYDRO-1,4-BENZOTHIAZEPINE, ANNEXIN V | Authors: | Ago, H, Inagaki, E, Miyano, M. | Deposit date: | 1997-12-10 | Release date: | 1999-02-16 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. J.Mol.Biol., 274, 1997
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3PGW
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![BU of 3pgw by Molmil](/molmil-images/mine/3pgw) | Crystal structure of human U1 snRNP | Descriptor: | DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3', Sm B, Sm G, ... | Authors: | Weber, G, Trowitzsch, S, Kastner, B, Luehrmann, R, Wahl, M.C. | Deposit date: | 2010-11-02 | Release date: | 2010-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Functional organization of the Sm core in the crystal structure of human U1 snRNP. Embo J., 29, 2010
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1HH4
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![BU of 1hh4 by Molmil](/molmil-images/mine/1hh4) | Rac1-RhoGDI complex involved in NADPH oxidase activation | Descriptor: | GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Grizot, S, Faure, J, Fieschi, F, Vignais, P.V, Dagher, M.-C, Pebay-Peyroula, E. | Deposit date: | 2000-12-20 | Release date: | 2001-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of the Rac1-Rhogdi Complex Involved in Nadph Oxidase Activation Biochemistry, 40, 2001
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1LE9
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![BU of 1le9 by Molmil](/molmil-images/mine/1le9) | Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti | Descriptor: | 5'-D(*AP*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*AP*CP*TP*TP*TP*CP*CP*T)-3', NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT, ... | Authors: | Benjamin, B, Huang, D.B, Chen-Park, F.E, Sigler, P.B, Ghosh, G. | Deposit date: | 2002-04-09 | Release date: | 2003-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. J.Biol.Chem., 277, 2002
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1KBQ
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![BU of 1kbq by Molmil](/molmil-images/mine/1kbq) | Complex of Human NAD(P)H quinone Oxidoreductase with 5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione (ES936) | Descriptor: | 5-METHOXY-1,2-DIMETHYL-3-(4-NITROPHENOXYMETHYL)INDOLE-4,7-DIONE, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1 | Authors: | Faig, M, Bianchet, M.A, Amzel, L.M. | Deposit date: | 2001-11-06 | Release date: | 2002-01-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches. Biochemistry, 40, 2001
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3PJA
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![BU of 3pja by Molmil](/molmil-images/mine/3pja) | Crystal structure of human C3PO complex | Descriptor: | Translin, Translin-associated protein X | Authors: | Huang, N, Zhang, H. | Deposit date: | 2010-11-09 | Release date: | 2011-05-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of C3PO and mechanism of human RISC activation. Nat.Struct.Mol.Biol., 18, 2011
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3P5O
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![BU of 3p5o by Molmil](/molmil-images/mine/3p5o) | Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, Bromodomain-containing protein 4 | Authors: | Chung, C. | Deposit date: | 2010-10-09 | Release date: | 2010-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Suppression of inflammation by a synthetic histone mimic Nature, 468, 2010
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1H89
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![BU of 1h89 by Molmil](/molmil-images/mine/1h89) | CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX2 | Descriptor: | CAAT/ENHANCER BINDING PROTEIN BETA, DNA(5'-(*CP*CP*AP*GP*TP*CP*CP*GP*TP*TP*AP* AP*GP*GP*AP*TP*TP*GP*CP*GP*CP*CP*AP*CP*AP*T)-3'), DNA(5'-(*GP*AP*TP*GP*TP*GP*GP*CP*GP*CP*AP* AP*TP*CP*CP*TP*TP*AP*AP*CP*GP*GP*AP*CP*TP*G)-3'), ... | Authors: | Tahirov, T.H, Ogata, K. | Deposit date: | 2001-01-30 | Release date: | 2002-01-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Mechanism of C-Myb-C/Ebpbeta Cooperation from Separated Sites on a Promoter Cell(Cambridge,Mass.), 108, 2002
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1K8K
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![BU of 1k8k by Molmil](/molmil-images/mine/1k8k) | Crystal Structure of Arp2/3 Complex | Descriptor: | ACTIN-LIKE PROTEIN 2, ACTIN-LIKE PROTEIN 3, ARP2/3 COMPLEX 16 KDA SUBUNIT, ... | Authors: | Robinson, R.C, Turbedsky, K, Kaiser, D.A, Higgs, H.N, Marchand, J.-B, Choe, S, Pollard, T.D. | Deposit date: | 2001-10-24 | Release date: | 2001-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Arp2/3 Complex Science, 294, 2001
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1HFA
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![BU of 1hfa by Molmil](/molmil-images/mine/1hfa) | CALM-N N-terminal domain of clathrin assembly lymphoid myeloid leukaemia protein, PI(4,5)P2 complex | Descriptor: | CLATHRIN ASSEMBLY PROTEIN SHORT FORM, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Ford, M.G.J, Evans, P.R, McMahon, H.T. | Deposit date: | 2000-11-30 | Release date: | 2001-02-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Simultaneous Binding of Ptdins(4,5)P2 and Clathrin by Ap180 in the Nucleation of Clathrin Lattices on Membranes Science, 291, 2001
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1H66
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![BU of 1h66 by Molmil](/molmil-images/mine/1h66) | CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE CO WITH 2,5-diaziridinyl-3-hydroxyl-6-methyl-1,4-benzoquinone | Descriptor: | 2,5-DIAZIRIDIN-1-YL-3-(HYDROXYMETHYL)-6-METHYLCYCLOHEXA-2,5-DIENE-1,4-DIONE, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H DEHYDROGENASE [QUINONE] 1 | Authors: | Faig, M, Bianchet, M.A, Winski, S, Ross, D, Amzel, L.M. | Deposit date: | 2001-06-06 | Release date: | 2001-09-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Based Development of Anticancer Drugs: Complexes of Nad(P)H:Quinone Oxidoreductase 1 with Chemotherapeutic Quinones Structure, 9, 2001
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1H6K
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![BU of 1h6k by Molmil](/molmil-images/mine/1h6k) | nuclear Cap Binding Complex | Descriptor: | 20 KDA NUCLEAR CAP BINDING PROTEIN, CBP80 | Authors: | Mazza, C, Ohno, M, Segref, A, Mattaj, I.W, Cusack, S. | Deposit date: | 2001-06-18 | Release date: | 2001-09-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Human Nuclear CAP Binding Complex Mol.Cell, 8, 2001
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3MOS
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![BU of 3mos by Molmil](/molmil-images/mine/3mos) | The structure of human Transketolase | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, SODIUM ION, ... | Authors: | Parthier, C, Tittmann, K. | Deposit date: | 2010-04-23 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The crystal structure of human transketolase and new insights into its mode of action. J.Biol.Chem., 285, 2010
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1HF8
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![BU of 1hf8 by Molmil](/molmil-images/mine/1hf8) | |
3MAX
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![BU of 3max by Molmil](/molmil-images/mine/3max) | |
1HG2
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![BU of 1hg2 by Molmil](/molmil-images/mine/1hg2) | CALM-N N-terminal domain of clathrin assembly lymphoid myeloid leukaemia protein, Inositol(4,5)P2 complex | Descriptor: | CLATHRIN ASSEMBLY PROTEIN SHORT FORM, D-MYO-INOSITOL-4,5-BISPHOSPHATE | Authors: | Ford, M.G.J, Evans, P.R, McMahon, H.T. | Deposit date: | 2000-12-12 | Release date: | 2001-02-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Simultaneous Binding of Ptdins(4,5)P2 and Clathrin by Ap180 in the Nucleation of Clathrin Lattices on Membranes Science, 291, 2001
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3ODS
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![BU of 3ods by Molmil](/molmil-images/mine/3ods) | |
1HD1
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![BU of 1hd1 by Molmil](/molmil-images/mine/1hd1) | HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0 (HNRNP D0 RBD1), NMR | Descriptor: | PROTEIN (HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0) | Authors: | Nagata, T, Kurihara, Y, Matsuda, G, Saeki, J, Kohno, T, Yanagida, Y, Ishikawa, F, Uesugi, S, Katahira, M. | Deposit date: | 1999-05-18 | Release date: | 2000-05-18 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. J.Mol.Biol., 287, 1999
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3O51
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![BU of 3o51 by Molmil](/molmil-images/mine/3o51) | Crystal structure of anthranilamide 10 bound to AuroraA | Descriptor: | N-[4-({3-[5-fluoro-2-(methylideneamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-2-(phenylamino)benzamide, cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 | Authors: | Huang, X. | Deposit date: | 2010-07-27 | Release date: | 2010-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor. J.Med.Chem., 53, 2010
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1JWH
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![BU of 1jwh by Molmil](/molmil-images/mine/1jwh) | Crystal Structure of Human Protein Kinase CK2 Holoenzyme | Descriptor: | Casein kinase II beta chain, Casein kinase II, alpha chain, ... | Authors: | Niefind, K, Guerra, B, Ermakowa, I, Issinger, O.G. | Deposit date: | 2001-09-04 | Release date: | 2002-03-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO J., 20, 2001
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1JPW
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![BU of 1jpw by Molmil](/molmil-images/mine/1jpw) | Crystal Structure of a Human Tcf-4 / beta-Catenin Complex | Descriptor: | BETA-CATENIN, transcription factor 7-like 2 | Authors: | Poy, F, Lepourcelet, M, Shivdasani, R.A, Eck, M.J. | Deposit date: | 2001-08-03 | Release date: | 2001-12-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of a human Tcf4-beta-catenin complex. Nat.Struct.Biol., 8, 2001
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1HW3
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![BU of 1hw3 by Molmil](/molmil-images/mine/1hw3) | STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, THYMIDYLATE SYNTHASE | Authors: | Phan, J, Steadman, J.D, Koli, S, Ding, W.C, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L. | Deposit date: | 2001-01-09 | Release date: | 2001-01-24 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. J.Biol.Chem., 276, 2001
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1HVY
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![BU of 1hvy by Molmil](/molmil-images/mine/1hvy) | Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, THYMIDYLATE SYNTHASE, ... | Authors: | Phan, J, Koli, S, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L. | Deposit date: | 2001-01-08 | Release date: | 2001-01-31 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug Biochemistry, 40, 2001
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1HM6
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![BU of 1hm6 by Molmil](/molmil-images/mine/1hm6) | |
3N5E
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![BU of 3n5e by Molmil](/molmil-images/mine/3n5e) | Crystal Structure of human thymidylate synthase bound to a peptide inhibitor | Descriptor: | SULFATE ION, Synthetic peptide LR, Thymidylate synthase | Authors: | Pozzi, C, Cardinale, D, Guaitoli, G, Tondi, D, Luciani, R, Myllykallio, H, Ferrari, S, Costi, M.P, Mangani, S. | Deposit date: | 2010-05-25 | Release date: | 2011-06-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc.Natl.Acad.Sci.USA, 108, 2011
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