1KBQ

Complex of Human NAD(P)H quinone Oxidoreductase with 5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione (ES936)

Summary for 1KBQ

Entry DOI	10.2210/pdb1kbq/pdb
Related	1D4A 1GG5 1H66 1H69 1KBO 1QRD
Descriptor	NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, 5-METHOXY-1,2-DIMETHYL-3-(4-NITROPHENOXYMETHYL)INDOLE-4,7-DIONE, ... (4 entities in total)
Functional Keywords	flavoenzyme, prodrug-enzyme complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15559
Total number of polymer chains	4
Total formula weight	127673.16
Authors	Faig, M.,Bianchet, M.A.,Amzel, L.M. (deposition date: 2001-11-06, release date: 2002-01-16, Last modification date: 2023-08-16)
Primary citation	Winski, S.L.,Faig, M.,Bianchet, M.A.,Siegel, D.,Swann, E.,Fung, K.,Duncan, M.W.,Moody, C.J.,Amzel, L.M.,Ross, D. Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches. Biochemistry, 40:15135-15142, 2001 Cited by PubMed: 11735396 DOI: 10.1021/bi011324i PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation